The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial
Objective: We aimed to examine the effect of doxycycline on serum levels of neuron-specific enolase (NSE), a marker of neuronal damage in traumatic brain injury (TBI) patients. Methods: Patients were randomly assigned into two groups ( n = 25 each) to receive either placebo or doxycycline (200 mg d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-06-01
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| Series: | Therapeutic Advances in Chronic Disease |
| Online Access: | https://doi.org/10.1177/20406223211024362 |
| _version_ | 1819106048125960192 |
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| author | Noha O. Mansour Mohamed A. Shama Rehab H. Werida |
| author_facet | Noha O. Mansour Mohamed A. Shama Rehab H. Werida |
| author_sort | Noha O. Mansour |
| collection | DOAJ |
| description | Objective: We aimed to examine the effect of doxycycline on serum levels of neuron-specific enolase (NSE), a marker of neuronal damage in traumatic brain injury (TBI) patients. Methods: Patients were randomly assigned into two groups ( n = 25 each) to receive either placebo or doxycycline (200 mg daily), with their standard management for 7 days. Results: NSE serum levels in the doxycycline and control groups on day 3 were 14.66 ± 1.78 versus 18.09 ± 4.38 ng/mL, respectively ( p = 0.008), and on day 7 were 12.3 ± 2.0 versus 16.43 ± 3.85 ng/mL, respectively ( p = 0.003). Glasgow Coma Scale (GCS) on day 7 was 11.90 ± 2.83 versus 9.65 ± 3.44 in the doxycycline and control groups, respectively ( p = 0.031). NSE serum levels and GCS scores were negatively correlated ( r = −0.569, p < 0.001). Conclusion: Adjunctive early use of doxycycline might be a novel option that halts the ongoing secondary brain injury in patients with moderate to severe TBI. Future larger clinical trials are warranted to confirm these findings. |
| first_indexed | 2024-12-22T02:31:56Z |
| format | Article |
| id | doaj.art-4889a810c9b44d23a28c7276268d37dc |
| institution | Directory Open Access Journal |
| issn | 2040-6231 |
| language | English |
| last_indexed | 2024-12-22T02:31:56Z |
| publishDate | 2021-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Chronic Disease |
| spelling | doaj.art-4889a810c9b44d23a28c7276268d37dc2022-12-21T18:41:51ZengSAGE PublishingTherapeutic Advances in Chronic Disease2040-62312021-06-011210.1177/20406223211024362The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trialNoha O. MansourMohamed A. ShamaRehab H. WeridaObjective: We aimed to examine the effect of doxycycline on serum levels of neuron-specific enolase (NSE), a marker of neuronal damage in traumatic brain injury (TBI) patients. Methods: Patients were randomly assigned into two groups ( n = 25 each) to receive either placebo or doxycycline (200 mg daily), with their standard management for 7 days. Results: NSE serum levels in the doxycycline and control groups on day 3 were 14.66 ± 1.78 versus 18.09 ± 4.38 ng/mL, respectively ( p = 0.008), and on day 7 were 12.3 ± 2.0 versus 16.43 ± 3.85 ng/mL, respectively ( p = 0.003). Glasgow Coma Scale (GCS) on day 7 was 11.90 ± 2.83 versus 9.65 ± 3.44 in the doxycycline and control groups, respectively ( p = 0.031). NSE serum levels and GCS scores were negatively correlated ( r = −0.569, p < 0.001). Conclusion: Adjunctive early use of doxycycline might be a novel option that halts the ongoing secondary brain injury in patients with moderate to severe TBI. Future larger clinical trials are warranted to confirm these findings.https://doi.org/10.1177/20406223211024362 |
| spellingShingle | Noha O. Mansour Mohamed A. Shama Rehab H. Werida The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial Therapeutic Advances in Chronic Disease |
| title | The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial |
| title_full | The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial |
| title_fullStr | The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial |
| title_full_unstemmed | The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial |
| title_short | The effect of doxycycline on neuron-specific enolase in patients with traumatic brain injury: a randomized controlled trial |
| title_sort | effect of doxycycline on neuron specific enolase in patients with traumatic brain injury a randomized controlled trial |
| url | https://doi.org/10.1177/20406223211024362 |
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