Novel method for the genomic analysis of PKD1 mutation in autosomal dominant polycystic kidney disease

Novel method for the genomic analysis of PKD1 mutation in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. Although next-generation sequencing (NGS) technology can be used to sequence tens of thousands of DNA molecules simultaneously. It has poor capture efficiency for the six PKD1 pseudogenes and GC-rich re...

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Bibliographic Details
Main Authors: Shunlai Shang, Chao Wang, Lang Chen, Wanjun Shen, Yuansheng Xie, Wenge Li, Qinggang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ADPKD
PKD1
mPCR
MLPA (multiplex ligation-dependent probe amplification)
targeted region sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.937580/full

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