Synthesis, crystal structure, thermal stability and biological study of bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) complex
A Schiff base complex of nickel, bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) was synthesised by condensing bis(2-hydroxy-3-methoxybenzaldehyde) nickel (II) and n-propylamine in methanolic medium. Single crystal X-ray diffraction analysis of the complex revealed it to possess plana...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024001397 |
| _version_ | 1797328725428142080 |
|---|---|
| author | S. Sindhu S. Arockiasamy |
| author_facet | S. Sindhu S. Arockiasamy |
| author_sort | S. Sindhu |
| collection | DOAJ |
| description | A Schiff base complex of nickel, bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) was synthesised by condensing bis(2-hydroxy-3-methoxybenzaldehyde) nickel (II) and n-propylamine in methanolic medium. Single crystal X-ray diffraction analysis of the complex revealed it to possess planar geometry with a monoclinic crystal system. The non-isothermal TG/DTA runs on this complex in a high purity (99.99 %) nitrogen environment at atmospheric pressure confirmed the absence of any coordinated water. A sharp endotherm in its DTA shows a melting temperature range of 168–171 °C. It is thermally stable up to 243 °C and decomposes in two steps, yielding NiO and carbon as residue. In addition to the methoxy group (-OCH3), infrared analysis (IR) confirmed the presence of the characteristic azomethine group (-CN-) which is also responsible for the biological action. It was further analysed by elemental analyser (C, H, N), 1H and 13C NMR as well as mass spectrometry. It showed considerable antibacterial activity towards Escherichia coli and Staphylococcus aureus when the concentration exceeds 200 μg/ml. The antifungal study shows significant inhibition with the antifungal drug imidazole as a positive control (PC). Small values of MIC, MBC/MIC indicate a lesser quantity of complex is required to inhibit the growth of micro-organisms. |
| first_indexed | 2024-03-08T06:55:49Z |
| format | Article |
| id | doaj.art-488b597c803343588b67376509055980 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:55:49Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-488b597c803343588b673765090559802024-02-03T06:36:14ZengElsevierHeliyon2405-84402024-01-01102e24108Synthesis, crystal structure, thermal stability and biological study of bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) complexS. Sindhu0S. Arockiasamy1Physics Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai, 127, IndiaChemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai, 127, India; Corresponding author. Vellore Institute of Technology-Chennai campus, Chennai-600127, India.A Schiff base complex of nickel, bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) was synthesised by condensing bis(2-hydroxy-3-methoxybenzaldehyde) nickel (II) and n-propylamine in methanolic medium. Single crystal X-ray diffraction analysis of the complex revealed it to possess planar geometry with a monoclinic crystal system. The non-isothermal TG/DTA runs on this complex in a high purity (99.99 %) nitrogen environment at atmospheric pressure confirmed the absence of any coordinated water. A sharp endotherm in its DTA shows a melting temperature range of 168–171 °C. It is thermally stable up to 243 °C and decomposes in two steps, yielding NiO and carbon as residue. In addition to the methoxy group (-OCH3), infrared analysis (IR) confirmed the presence of the characteristic azomethine group (-CN-) which is also responsible for the biological action. It was further analysed by elemental analyser (C, H, N), 1H and 13C NMR as well as mass spectrometry. It showed considerable antibacterial activity towards Escherichia coli and Staphylococcus aureus when the concentration exceeds 200 μg/ml. The antifungal study shows significant inhibition with the antifungal drug imidazole as a positive control (PC). Small values of MIC, MBC/MIC indicate a lesser quantity of complex is required to inhibit the growth of micro-organisms.http://www.sciencedirect.com/science/article/pii/S2405844024001397Schiff baseNickel complexesThermal analysisBiological activitySpectral analysis |
| spellingShingle | S. Sindhu S. Arockiasamy Synthesis, crystal structure, thermal stability and biological study of bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) complex Heliyon Schiff base Nickel complexes Thermal analysis Biological activity Spectral analysis |
| title | Synthesis, crystal structure, thermal stability and biological study of bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) complex |
| title_full | Synthesis, crystal structure, thermal stability and biological study of bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) complex |
| title_fullStr | Synthesis, crystal structure, thermal stability and biological study of bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) complex |
| title_full_unstemmed | Synthesis, crystal structure, thermal stability and biological study of bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) complex |
| title_short | Synthesis, crystal structure, thermal stability and biological study of bis{(2-methoxy-6-[(E)-(propylimino)methyl]phenolato}nickel(II) complex |
| title_sort | synthesis crystal structure thermal stability and biological study of bis 2 methoxy 6 e propylimino methyl phenolato nickel ii complex |
| topic | Schiff base Nickel complexes Thermal analysis Biological activity Spectral analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024001397 |
| work_keys_str_mv | AT ssindhu synthesiscrystalstructurethermalstabilityandbiologicalstudyofbis2methoxy6epropyliminomethylphenolatonickeliicomplex AT sarockiasamy synthesiscrystalstructurethermalstabilityandbiologicalstudyofbis2methoxy6epropyliminomethylphenolatonickeliicomplex |