Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3
The autoimmune disorder systemic lupus erythematosus (SLE) is multifaceted, with limited therapeutic alternatives and detrimental side effects, particularly on bones and joints. This research endeavors to examine the curative potential and underlying mechanisms of in addressing SLE-associated bone a...
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PeerJ Inc.
2023-06-01
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| Online Access: | https://peerj.com/articles/15395.pdf |
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| author | Qinyao Xu Xiangzhi Zhang Shangqing Ge Chang Xu Yuanfan Lv Zongwen Shuai |
| author_facet | Qinyao Xu Xiangzhi Zhang Shangqing Ge Chang Xu Yuanfan Lv Zongwen Shuai |
| author_sort | Qinyao Xu |
| collection | DOAJ |
| description | The autoimmune disorder systemic lupus erythematosus (SLE) is multifaceted, with limited therapeutic alternatives and detrimental side effects, particularly on bones and joints. This research endeavors to examine the curative potential and underlying mechanisms of in addressing SLE-associated bone and joint complications. Triptoquinone A and triptoquinone B, constituents of Tripterygium wilfordii polyglycoside tablets (TGTs), exhibit antioxidant and anti-inflammatory attributes; nonetheless, its function in SLE therapy remains elusive. This investigation delves into the role of oxidative stress in systemic lupus erythematosus (SLE) and probes the prospective remedial effects of triptoquinone A and triptoquinone B on inflammation and cartilage deterioration in SLE-affected joints. Employing bioinformatics analyses, differentially expressed genes (DEGs) and protein-protein interactions were discerned in SLE, rheumatoid arthritis (RA), and osteoarthritis (OA) datasets. Enrichment analyses unveiled shared genes implicated in immune system regulation and toll-like receptor signaling pathways, among others. Subsequent examination of triptoquinone A and triptoquinone B revealed their capacity to diminish NLRC3 expression in chondrocytes, resulting in decreased pro-inflammatory cytokine levels and cartilage degradation enzyme expression. Suppression of NLRC3 augmented the protective effects of triptoquinone A and B, implying that targeting NLRC3 may constitute a potential therapeutic strategy for inflammation and cartilage degeneration-associated conditions in SLE patients. Our discoveries indicate that triptoquinone A and triptoquinone B may impede SLE progression via the NLRC3 axis, offering potential benefits for SLE-affected bone and joint health. |
| first_indexed | 2024-03-09T07:55:30Z |
| format | Article |
| id | doaj.art-488bd2c99125496cbbb9b23ee268cf88 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:55:30Z |
| publishDate | 2023-06-01 |
| publisher | PeerJ Inc. |
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| series | PeerJ |
| spelling | doaj.art-488bd2c99125496cbbb9b23ee268cf882023-12-03T01:03:57ZengPeerJ Inc.PeerJ2167-83592023-06-0111e1539510.7717/peerj.15395Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3Qinyao Xu0Xiangzhi Zhang1Shangqing Ge2Chang Xu3Yuanfan Lv4Zongwen Shuai5Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Internal Medicine, School Hospital of Anhui Medical University, Hefei, ChinaDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaThe autoimmune disorder systemic lupus erythematosus (SLE) is multifaceted, with limited therapeutic alternatives and detrimental side effects, particularly on bones and joints. This research endeavors to examine the curative potential and underlying mechanisms of in addressing SLE-associated bone and joint complications. Triptoquinone A and triptoquinone B, constituents of Tripterygium wilfordii polyglycoside tablets (TGTs), exhibit antioxidant and anti-inflammatory attributes; nonetheless, its function in SLE therapy remains elusive. This investigation delves into the role of oxidative stress in systemic lupus erythematosus (SLE) and probes the prospective remedial effects of triptoquinone A and triptoquinone B on inflammation and cartilage deterioration in SLE-affected joints. Employing bioinformatics analyses, differentially expressed genes (DEGs) and protein-protein interactions were discerned in SLE, rheumatoid arthritis (RA), and osteoarthritis (OA) datasets. Enrichment analyses unveiled shared genes implicated in immune system regulation and toll-like receptor signaling pathways, among others. Subsequent examination of triptoquinone A and triptoquinone B revealed their capacity to diminish NLRC3 expression in chondrocytes, resulting in decreased pro-inflammatory cytokine levels and cartilage degradation enzyme expression. Suppression of NLRC3 augmented the protective effects of triptoquinone A and B, implying that targeting NLRC3 may constitute a potential therapeutic strategy for inflammation and cartilage degeneration-associated conditions in SLE patients. Our discoveries indicate that triptoquinone A and triptoquinone B may impede SLE progression via the NLRC3 axis, offering potential benefits for SLE-affected bone and joint health.https://peerj.com/articles/15395.pdfTriptoquinoneSystemic lupus erythematosus (SLE)Oxidative stressInflammationApoptosisNLRC3 |
| spellingShingle | Qinyao Xu Xiangzhi Zhang Shangqing Ge Chang Xu Yuanfan Lv Zongwen Shuai Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3 PeerJ Triptoquinone Systemic lupus erythematosus (SLE) Oxidative stress Inflammation Apoptosis NLRC3 |
| title | Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3 |
| title_full | Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3 |
| title_fullStr | Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3 |
| title_full_unstemmed | Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3 |
| title_short | Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3 |
| title_sort | triptoquinone a and b exercise a therapeutic effect in systemic lupus erythematosus by regulating nlrc3 |
| topic | Triptoquinone Systemic lupus erythematosus (SLE) Oxidative stress Inflammation Apoptosis NLRC3 |
| url | https://peerj.com/articles/15395.pdf |
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