Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats
Background & Objective: Narcotics abuse can induce liver disorders; nevertheless, exercises improve liver disorders. The present research aimed to review the effect of eight weeks forced swimming training with methadone supplementation on liver enzymes of rats. Material & Method: In this ex...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2016-11-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-1043-en.pdf |
| _version_ | 1797679618683043840 |
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| author | Seyed Ali Hoseini Abdosaleh Zar Seyed Ali Hoseini Ghobad Hassanpour Maryam Kheirdeh Mehdi Noura |
| author_facet | Seyed Ali Hoseini Abdosaleh Zar Seyed Ali Hoseini Ghobad Hassanpour Maryam Kheirdeh Mehdi Noura |
| author_sort | Seyed Ali Hoseini |
| collection | DOAJ |
| description | Background & Objective: Narcotics abuse can induce liver disorders; nevertheless, exercises improve liver disorders. The present research aimed to review the effect of eight weeks forced swimming training with methadone supplementation on liver enzymes of rats.
Material & Method: In this experimental research, 48 rats were selected, and after one week adaptation to lab environment, they were randomly divided into four groups of 12 rats including (1) forced swimming training, (2) methadone supplementation, (3) forced swimming training with methadone supplementation, and (4) control. Groups 2 and 3 used 2 mg/kg methadone daily for 8 weeks. Also, groups 1 and 3 swam for 8 weeks, three sessions per week and each session for 30 minutes. For statistical analysis of data, one way ANOVA and Tukey post hoc tests were used (α≤0.05).
Results: Findings showed that forced swimming training, methadone supplementation, and forced swimming training with methadone supplementation had no significant effect on AST (P=0.90) and ALT (P=0.99) enzymes; forced swimming training had significant effect on increase of ALP (P=0.001); also, forced swimming training, compared with methadone supplementation and combination of forced swimming training with methadone supplementation, had significant effect on increase of ALP (P=0.001).
Conclusion: Accordingly, 8 weeks of forced swimming training with methadone has possibly no significant effect on liver enzymes. |
| first_indexed | 2024-03-11T23:17:25Z |
| format | Article |
| id | doaj.art-488ccd3180db4e05a7534109bfd16e8f |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:17:25Z |
| publishDate | 2016-11-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-488ccd3180db4e05a7534109bfd16e8f2023-09-20T21:22:21ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232016-11-0163389398Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of RatsSeyed Ali Hoseini0Abdosaleh Zar1Seyed Ali Hoseini2Ghobad Hassanpour3Maryam Kheirdeh4Mehdi Noura5 Sport Physiology Department, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Sport Physiology Department, University of Jahrom, Jahrom, Iran Sport Physiology Department, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Sport Physiology Department, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Physical Education Department of Sama Collage, Shiraz Branch, Islamic Azad University, Shiraz, Iran Sport Physiology Department, Shiraz Branch, Islamic Azad University, Shiraz, Iran Background & Objective: Narcotics abuse can induce liver disorders; nevertheless, exercises improve liver disorders. The present research aimed to review the effect of eight weeks forced swimming training with methadone supplementation on liver enzymes of rats. Material & Method: In this experimental research, 48 rats were selected, and after one week adaptation to lab environment, they were randomly divided into four groups of 12 rats including (1) forced swimming training, (2) methadone supplementation, (3) forced swimming training with methadone supplementation, and (4) control. Groups 2 and 3 used 2 mg/kg methadone daily for 8 weeks. Also, groups 1 and 3 swam for 8 weeks, three sessions per week and each session for 30 minutes. For statistical analysis of data, one way ANOVA and Tukey post hoc tests were used (α≤0.05). Results: Findings showed that forced swimming training, methadone supplementation, and forced swimming training with methadone supplementation had no significant effect on AST (P=0.90) and ALT (P=0.99) enzymes; forced swimming training had significant effect on increase of ALP (P=0.001); also, forced swimming training, compared with methadone supplementation and combination of forced swimming training with methadone supplementation, had significant effect on increase of ALP (P=0.001). Conclusion: Accordingly, 8 weeks of forced swimming training with methadone has possibly no significant effect on liver enzymes.http://jabs.fums.ac.ir/article-1-1043-en.pdfforced swimming trainingaspartate aminotransferasealanine aminotransferasealkaline phosphatasemethadone |
| spellingShingle | Seyed Ali Hoseini Abdosaleh Zar Seyed Ali Hoseini Ghobad Hassanpour Maryam Kheirdeh Mehdi Noura Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats Journal of Advanced Biomedical Sciences forced swimming training aspartate aminotransferase alanine aminotransferase alkaline phosphatase methadone |
| title | Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats |
| title_full | Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats |
| title_fullStr | Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats |
| title_full_unstemmed | Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats |
| title_short | Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats |
| title_sort | effect of eight weeks forced swimming training with methadone supplementation on aspartate aminotransferase alanine aminotransferase and alkaline phosphatase of rats |
| topic | forced swimming training aspartate aminotransferase alanine aminotransferase alkaline phosphatase methadone |
| url | http://jabs.fums.ac.ir/article-1-1043-en.pdf |
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