MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis
IntroductionWithin tumor microenvironment, the presence of preexisting antitumor CD8+ T Q7 cells have been shown to be associated with a favorable prognosis in most solid cancers. However, in the case of prostate cancer (PCa), they have been linked to a negative impact on prognosis.MethodsTo gain a...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364329/full |
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| author | Yuanming Fan Yuqiu Ge Kaiming Niu Ying Li Lian-Wen Qi Haixia Zhu Gaoxiang Ma Gaoxiang Ma |
| author_facet | Yuanming Fan Yuqiu Ge Kaiming Niu Ying Li Lian-Wen Qi Haixia Zhu Gaoxiang Ma Gaoxiang Ma |
| author_sort | Yuanming Fan |
| collection | DOAJ |
| description | IntroductionWithin tumor microenvironment, the presence of preexisting antitumor CD8+ T Q7 cells have been shown to be associated with a favorable prognosis in most solid cancers. However, in the case of prostate cancer (PCa), they have been linked to a negative impact on prognosis.MethodsTo gain a deeper understanding of the contribution of infiltrating CD8+ T cells to poor prognosis in PCa, the infiltration levelsof CD8+ T cells were estimated using the TCGA PRAD (The Cancer Genome Atlas Prostate Adenocarcinoma dataset) and MSKCC (Memorial Sloan Kettering Cancer Center) cohorts.ResultsBioinformatic analyses revealed that CD8+ T cells likely influence PCa prognosis through increased expression of immune checkpoint molecules and enhanced recruitment of regulatory T cells. The MLXIPL was identified as the gene expressed in response to CD8+ T cell infiltration and was found to be associated with PCa prognosis. The prognostic role of MLXIPL was examined in two cohorts: TCGA PRAD (p = 2.3E-02) and the MSKCC cohort (p = 1.6E-02). Subsequently, MLXIPL was confirmed to be associated with an unfavorable prognosis in PCa, as evidenced by an independent cohort study (hazard ratio [HR] = 2.57, 95% CI: 1.42- 4.65, p = 1.76E-03).DiscussionIn summary, the findings suggested that MLXIPL related to tumor-infiltrating CD8+ T cells facilitated a poor prognosis in PCa. |
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| language | English |
| last_indexed | 2024-04-24T07:57:00Z |
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| series | Frontiers in Immunology |
| spelling | doaj.art-488dcae83392466bbe8afa842006e2012024-04-18T04:44:30ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-04-011510.3389/fimmu.2024.13643291364329MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosisYuanming Fan0Yuqiu Ge1Kaiming Niu2Ying Li3Lian-Wen Qi4Haixia Zhu5Gaoxiang Ma6Gaoxiang Ma7State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaDepartment of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, ChinaState Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaState Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaThe Clinical Metabolomics Center, China Pharmaceutical University, Nanjing, ChinaClinical Laboratory, Tumor Hospital Affiliated to Nantong University, Nantong, ChinaState Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, ChinaDepartment of Oncology, Pukou Hospital of Chinese Medicine affiliated to China Pharmaceutical University, Nanjing, ChinaIntroductionWithin tumor microenvironment, the presence of preexisting antitumor CD8+ T Q7 cells have been shown to be associated with a favorable prognosis in most solid cancers. However, in the case of prostate cancer (PCa), they have been linked to a negative impact on prognosis.MethodsTo gain a deeper understanding of the contribution of infiltrating CD8+ T cells to poor prognosis in PCa, the infiltration levelsof CD8+ T cells were estimated using the TCGA PRAD (The Cancer Genome Atlas Prostate Adenocarcinoma dataset) and MSKCC (Memorial Sloan Kettering Cancer Center) cohorts.ResultsBioinformatic analyses revealed that CD8+ T cells likely influence PCa prognosis through increased expression of immune checkpoint molecules and enhanced recruitment of regulatory T cells. The MLXIPL was identified as the gene expressed in response to CD8+ T cell infiltration and was found to be associated with PCa prognosis. The prognostic role of MLXIPL was examined in two cohorts: TCGA PRAD (p = 2.3E-02) and the MSKCC cohort (p = 1.6E-02). Subsequently, MLXIPL was confirmed to be associated with an unfavorable prognosis in PCa, as evidenced by an independent cohort study (hazard ratio [HR] = 2.57, 95% CI: 1.42- 4.65, p = 1.76E-03).DiscussionIn summary, the findings suggested that MLXIPL related to tumor-infiltrating CD8+ T cells facilitated a poor prognosis in PCa.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364329/fullprostate cancerprognosisCD8+ T cellMLXIPLcohort study |
| spellingShingle | Yuanming Fan Yuqiu Ge Kaiming Niu Ying Li Lian-Wen Qi Haixia Zhu Gaoxiang Ma Gaoxiang Ma MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis Frontiers in Immunology prostate cancer prognosis CD8+ T cell MLXIPL cohort study |
| title | MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis |
| title_full | MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis |
| title_fullStr | MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis |
| title_full_unstemmed | MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis |
| title_short | MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis |
| title_sort | mlxipl associated with tumor infiltrating cd8 t cells is involved in poor prostate cancer prognosis |
| topic | prostate cancer prognosis CD8+ T cell MLXIPL cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364329/full |
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