Adenoid Cystic Carcinoma of the Breast: An Oncological Center's Experience
Background: Adenoid cystic carcinoma of the breast (ACCB) is a rare breast malignancy. Despite often being a triple negative tumor, it has a favorable prognosis, with low rates of recurrence and progression. The ideal treatment of ACCB is debatable; thus, the aim of this study was to characterize a...
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| Format: | Article |
| Language: | English |
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Kaviani Breast Disease Institute
2022-01-01
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| Series: | Archives of Breast Cancer |
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| Online Access: | https://www.archbreastcancer.com/index.php/abc/article/view/456 |
| _version_ | 1828854379947491328 |
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| author | Ana Margarida Correia Rafael Fernandes Teresa Dias Madalena Souto Moura Rita Canotilho Catarina Baía Paula Pinto Joaquim Abreu de Sousa |
| author_facet | Ana Margarida Correia Rafael Fernandes Teresa Dias Madalena Souto Moura Rita Canotilho Catarina Baía Paula Pinto Joaquim Abreu de Sousa |
| author_sort | Ana Margarida Correia |
| collection | DOAJ |
| description | Background: Adenoid cystic carcinoma of the breast (ACCB) is a rare breast malignancy. Despite often being a triple negative tumor, it has a favorable prognosis, with low rates of recurrence and progression. The ideal treatment of ACCB is debatable; thus, the aim of this study was to characterize a population diagnosed with ACCB and to evaluate the treatment outcomes.
Methods: We performed a single-center retrospective analysis of patients with a histological diagnosis of ACCB treated at our dedicated Oncological Center between 1987 and 2020. The patients were identified in collaboration with the Anatomical Pathology Department, which also reviewed the surgical pathology reports.
Results: Thirteen women with a median age of 68 years old were diagnosed with ACCB. The most frequent clinical diagnosis was a breast nodule (n=5); the preoperative image was suggestive of malignancy in nine patients, with seven being diagnosed with a ACCB in the preoperative biopsy. Regarding treatment, nine patients underwent conservative surgery, but three required re-excision. Sentinel lymph node biopsy (SLNB) was performed in seven patients, none revealing metastases; one patient had stage III ACCB and was initially treated with a modified radical mastectomy (MRM); the remaining were stage I (n=7) and II (n=5). Adjuvant radiotherapy was performed in eight patients, and two were initially proposed for chemotherapy but were considered unfit. With a median follow-up of 123 months (16-407), one case of local recurrence and two cases of distant metastasis were identified, one of whom died of disease.
Conclusion: ACCB is a rare tumor with a good prognosis; however, as demonstrated, it can present an aggressive behavior. Conservative surgery and adjuvant radiotherapy are the indicated treatment and SLNB may be omitted in grade 1 tumors. |
| first_indexed | 2024-12-13T00:31:53Z |
| format | Article |
| id | doaj.art-488f1505a2a54bf1b5406242f106443b |
| institution | Directory Open Access Journal |
| issn | 2383-0433 |
| language | English |
| last_indexed | 2024-12-13T00:31:53Z |
| publishDate | 2022-01-01 |
| publisher | Kaviani Breast Disease Institute |
| record_format | Article |
| series | Archives of Breast Cancer |
| spelling | doaj.art-488f1505a2a54bf1b5406242f106443b2022-12-22T00:05:17ZengKaviani Breast Disease InstituteArchives of Breast Cancer2383-04332022-01-019110.32768/abc.20229176-82Adenoid Cystic Carcinoma of the Breast: An Oncological Center's ExperienceAna Margarida Correia0Rafael Fernandes1Teresa Dias2Madalena Souto Moura3Rita Canotilho4Catarina Baía5Paula Pinto6Joaquim Abreu de Sousa7Surgical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalGeneral Surgery Department, Hospital de Santa Cruz – Centro Hospitalar de Lisboa Ocidental, Av. Prof. Dr. Reinaldo dos Santos, 2790-134 Carnaxide, Lisboa, PortugalSurgical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalAnatomical Pathology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalSurgical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalSurgical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalSurgical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalSurgical Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-Porto), Rua Dr. António Bernardino de Almeida, 4200-072 Porto, PortugalBackground: Adenoid cystic carcinoma of the breast (ACCB) is a rare breast malignancy. Despite often being a triple negative tumor, it has a favorable prognosis, with low rates of recurrence and progression. The ideal treatment of ACCB is debatable; thus, the aim of this study was to characterize a population diagnosed with ACCB and to evaluate the treatment outcomes. Methods: We performed a single-center retrospective analysis of patients with a histological diagnosis of ACCB treated at our dedicated Oncological Center between 1987 and 2020. The patients were identified in collaboration with the Anatomical Pathology Department, which also reviewed the surgical pathology reports. Results: Thirteen women with a median age of 68 years old were diagnosed with ACCB. The most frequent clinical diagnosis was a breast nodule (n=5); the preoperative image was suggestive of malignancy in nine patients, with seven being diagnosed with a ACCB in the preoperative biopsy. Regarding treatment, nine patients underwent conservative surgery, but three required re-excision. Sentinel lymph node biopsy (SLNB) was performed in seven patients, none revealing metastases; one patient had stage III ACCB and was initially treated with a modified radical mastectomy (MRM); the remaining were stage I (n=7) and II (n=5). Adjuvant radiotherapy was performed in eight patients, and two were initially proposed for chemotherapy but were considered unfit. With a median follow-up of 123 months (16-407), one case of local recurrence and two cases of distant metastasis were identified, one of whom died of disease. Conclusion: ACCB is a rare tumor with a good prognosis; however, as demonstrated, it can present an aggressive behavior. Conservative surgery and adjuvant radiotherapy are the indicated treatment and SLNB may be omitted in grade 1 tumors.https://www.archbreastcancer.com/index.php/abc/article/view/456Carcinoma, Adenoid Cystic, Breast Neoplasms, Surgical Oncology |
| spellingShingle | Ana Margarida Correia Rafael Fernandes Teresa Dias Madalena Souto Moura Rita Canotilho Catarina Baía Paula Pinto Joaquim Abreu de Sousa Adenoid Cystic Carcinoma of the Breast: An Oncological Center's Experience Archives of Breast Cancer Carcinoma, Adenoid Cystic, Breast Neoplasms, Surgical Oncology |
| title | Adenoid Cystic Carcinoma of the Breast: An Oncological Center's Experience |
| title_full | Adenoid Cystic Carcinoma of the Breast: An Oncological Center's Experience |
| title_fullStr | Adenoid Cystic Carcinoma of the Breast: An Oncological Center's Experience |
| title_full_unstemmed | Adenoid Cystic Carcinoma of the Breast: An Oncological Center's Experience |
| title_short | Adenoid Cystic Carcinoma of the Breast: An Oncological Center's Experience |
| title_sort | adenoid cystic carcinoma of the breast an oncological center s experience |
| topic | Carcinoma, Adenoid Cystic, Breast Neoplasms, Surgical Oncology |
| url | https://www.archbreastcancer.com/index.php/abc/article/view/456 |
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