Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors
Background: This study evaluates estrogen and progesterone expressions in patients with ovarian tumors (both benign and malignant) and their correlation with various clinicopathological prognostic parameters. Receptors for estrogen and progesterone are predictive and prognostic markers of endomet...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2014-03-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/161/126 |
| _version_ | 1811266093737574400 |
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| author | Shilpa Garg Nisha Marwah Gulshan Chauhan Sumiti Gupta Rajiv Goyal Pushpa Dahiya Promil Jain Rajiv Sen |
| author_facet | Shilpa Garg Nisha Marwah Gulshan Chauhan Sumiti Gupta Rajiv Goyal Pushpa Dahiya Promil Jain Rajiv Sen |
| author_sort | Shilpa Garg |
| collection | DOAJ |
| description | Background: This study evaluates estrogen and progesterone expressions in
patients with ovarian tumors (both benign and malignant) and their correlation with
various clinicopathological prognostic parameters. Receptors for estrogen and
progesterone are predictive and prognostic markers of endometrial and breast cancers.
However, their clinical significance in epithelial ovarian cancer is not clear due to
conflicting data from only a few immunohistochemical studies available in the
literature.
Methods: The present study was conducted on 60 cases of ovarian tumors, 20 benign
and 40 malignant. Estrogen and progesterone expressions were studied by immuno-
histochemistry and correlated with various clinicopathological parameters such as,
menopausal status, histological type, WHO grade and FIGO stage.
Results: Out of 20 benign tumors the estrogen receptor was positive in 10 (50%)
and progesterone receptor was positive in 14 (70%) tumors. In 40 malignant tumors,
the estrogen receptor was positive in 13 (32.5%) and progesterone receptor was
positive in 11 (27.5%) cases. There was statistically significant estrogen receptor
expression observed in serous tumors (P=0.001). When compared with other clinico-
pathological parameters, we noted a significant association between progesterone
receptor expression and favorable prognostic parameters such as young age, benign
tumors and early FIGO stage.
Conclusion: There were variable expressions of the estrogen and progesterone
receptors in ovarian tumors. Progesterone receptor expression was associated with
favorable prognostic factors that included younger age, benign tumor and low FIGO
stage. No such association was observed with estrogen receptor expression. |
| first_indexed | 2024-04-12T20:35:53Z |
| format | Article |
| id | doaj.art-488f191055a64b4da364fbf7639b9b3e |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-04-12T20:35:53Z |
| publishDate | 2014-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-488f191055a64b4da364fbf7639b9b3e2022-12-22T03:17:34ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872014-03-015297103Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian TumorsShilpa Garg0Nisha Marwah1Gulshan Chauhan2Sumiti Gupta3Rajiv Goyal4Pushpa Dahiya5Promil Jain6Rajiv Sen7Department of Pathology and Gynecology, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Pathology and Gynecology, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Pathology and Gynecology, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Pathology and Gynecology, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Orthopaedics, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Pathology and Gynecology, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Pathology and Gynecology, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Pathology and Gynecology, Pt. B.D Sharma Post Graduate University of Medical Sciences, Rohtak, Haryana, IndiaBackground: This study evaluates estrogen and progesterone expressions in patients with ovarian tumors (both benign and malignant) and their correlation with various clinicopathological prognostic parameters. Receptors for estrogen and progesterone are predictive and prognostic markers of endometrial and breast cancers. However, their clinical significance in epithelial ovarian cancer is not clear due to conflicting data from only a few immunohistochemical studies available in the literature. Methods: The present study was conducted on 60 cases of ovarian tumors, 20 benign and 40 malignant. Estrogen and progesterone expressions were studied by immuno- histochemistry and correlated with various clinicopathological parameters such as, menopausal status, histological type, WHO grade and FIGO stage. Results: Out of 20 benign tumors the estrogen receptor was positive in 10 (50%) and progesterone receptor was positive in 14 (70%) tumors. In 40 malignant tumors, the estrogen receptor was positive in 13 (32.5%) and progesterone receptor was positive in 11 (27.5%) cases. There was statistically significant estrogen receptor expression observed in serous tumors (P=0.001). When compared with other clinico- pathological parameters, we noted a significant association between progesterone receptor expression and favorable prognostic parameters such as young age, benign tumors and early FIGO stage. Conclusion: There were variable expressions of the estrogen and progesterone receptors in ovarian tumors. Progesterone receptor expression was associated with favorable prognostic factors that included younger age, benign tumor and low FIGO stage. No such association was observed with estrogen receptor expression.http://mejc.sums.ac.ir/index.php/mejc/article/view/161/126EstrogenProgesteroneReceptorOvarian |
| spellingShingle | Shilpa Garg Nisha Marwah Gulshan Chauhan Sumiti Gupta Rajiv Goyal Pushpa Dahiya Promil Jain Rajiv Sen Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors Middle East Journal of Cancer Estrogen Progesterone Receptor Ovarian |
| title | Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors |
| title_full | Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors |
| title_fullStr | Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors |
| title_full_unstemmed | Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors |
| title_short | Estrogen and Progesterone Receptor Expression and its Correlation with Various Clinicopathological Parameters in Ovarian Tumors |
| title_sort | estrogen and progesterone receptor expression and its correlation with various clinicopathological parameters in ovarian tumors |
| topic | Estrogen Progesterone Receptor Ovarian |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/161/126 |
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