Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease
The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed to overcome this disease. In this review, researchers collected information about dysfunctional energy in neurodegenerative diseases driven by mitochondria. Mitochondrial dysregulation c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023053318 |
| _version_ | 1797771423181176832 |
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| author | Sri Widyarti Syahputra Wibowo Akhmad Sabarudin Intan Abhirama Sutiman Bambang Sumitro |
| author_facet | Sri Widyarti Syahputra Wibowo Akhmad Sabarudin Intan Abhirama Sutiman Bambang Sumitro |
| author_sort | Sri Widyarti |
| collection | DOAJ |
| description | The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed to overcome this disease. In this review, researchers collected information about dysfunctional energy in neurodegenerative diseases driven by mitochondria. Mitochondrial dysregulation can cause damage to the neuron system. The increase in the amount and interaction of α-synuclein with SAMM50 and GABARAPL1 in the mitochondria is one of the factors causing neurodegenerative disease. As an energy provider in the body, the existence of harmonization in the regulation of mitochondria, specifically the mitochondrial outer membrane, is important. Low-dose hydrogen peroxide (H2O2) has neuroprotective abilities to overcome the impairment function of mitochondria in neurodegenerative patients. Based on computational simulation of this case, it can be used as a basic concept for the development of the role of H2O2 in neurodegenerative diseases. |
| first_indexed | 2024-03-12T21:37:22Z |
| format | Article |
| id | doaj.art-488f5c95abb743d4a0409a085bbf9830 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T21:37:22Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-488f5c95abb743d4a0409a085bbf98302023-07-27T05:58:37ZengElsevierHeliyon2405-84402023-07-0197e18123Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative diseaseSri Widyarti0Syahputra Wibowo1Akhmad Sabarudin2Intan Abhirama3Sutiman Bambang Sumitro4Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, East Java, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, East Java, Indonesia; Postdoctoral Fellow, Faculty of Biology, Gadjah Mada University, Teknika Selatan Sekip Utara, 55281 Yogyakarta, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, East Java, IndonesiaDepartment of Neurology, Bogor Senior Hospital, Jl.Raya Tajur 16137, West Java, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, East Java, Indonesia; Corresponding author.The number of people with neurodegenerative disease continues to increase every year. A new perspective is needed to overcome this disease. In this review, researchers collected information about dysfunctional energy in neurodegenerative diseases driven by mitochondria. Mitochondrial dysregulation can cause damage to the neuron system. The increase in the amount and interaction of α-synuclein with SAMM50 and GABARAPL1 in the mitochondria is one of the factors causing neurodegenerative disease. As an energy provider in the body, the existence of harmonization in the regulation of mitochondria, specifically the mitochondrial outer membrane, is important. Low-dose hydrogen peroxide (H2O2) has neuroprotective abilities to overcome the impairment function of mitochondria in neurodegenerative patients. Based on computational simulation of this case, it can be used as a basic concept for the development of the role of H2O2 in neurodegenerative diseases.http://www.sciencedirect.com/science/article/pii/S2405844023053318α-SynucleinDysfunctional energyLow dose H2O2MitochondriaNeurodegenerative disease |
| spellingShingle | Sri Widyarti Syahputra Wibowo Akhmad Sabarudin Intan Abhirama Sutiman Bambang Sumitro Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease Heliyon α-Synuclein Dysfunctional energy Low dose H2O2 Mitochondria Neurodegenerative disease |
| title | Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease |
| title_full | Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease |
| title_fullStr | Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease |
| title_full_unstemmed | Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease |
| title_short | Dysfunctional energy and future perspective of low dose H2O2 as protective agent in neurodegenerative disease |
| title_sort | dysfunctional energy and future perspective of low dose h2o2 as protective agent in neurodegenerative disease |
| topic | α-Synuclein Dysfunctional energy Low dose H2O2 Mitochondria Neurodegenerative disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023053318 |
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