Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes
<b>Background:</b> Phenolic compounds are food-derived bioactive compounds well-known for their antioxidant and anti-inflammatory properties. They are in the spotlight for the management of diabetes due to their positive effects on glucose homeostasis. <b>Materials and methods:<...
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MDPI AG
2022-09-01
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| Series: | Applied Sciences |
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| author | Marisol Dias Marina Romaní-Pérez Aloia Romaní Aimara de la Cruz Lorenzo Pastrana Pablo Fuciños Isabel R. Amado |
| author_facet | Marisol Dias Marina Romaní-Pérez Aloia Romaní Aimara de la Cruz Lorenzo Pastrana Pablo Fuciños Isabel R. Amado |
| author_sort | Marisol Dias |
| collection | DOAJ |
| description | <b>Background:</b> Phenolic compounds are food-derived bioactive compounds well-known for their antioxidant and anti-inflammatory properties. They are in the spotlight for the management of diabetes due to their positive effects on glucose homeostasis. <b>Materials and methods:</b> We have performed a literature review on the main topics related to the application of phenolic compounds as functional food ingredients. This includes extraction and purification from vegetable sources and agro-industrial by-products, encapsulation to improve their solubility and bioavailability, and preclinical and clinical evidence linking these compounds with anti-diabetic activity. <b>Objectives:</b> (1) provide an understanding of the role of phenolic compounds on diabetes; (2) identify green technologies for phenolic compounds extraction from agri-food by-products following a biorefinery scheme; (3) underline the relevance of encapsulation techniques using nanotechnology to improve their bioavailability; (4) discuss the therapeutic efficacy of polyphenols. <b>Results</b>: This review compiles recent relevant research on phenolic compounds extraction from renewable resources, their purification from agri-food by-products, and encapsulation strategies using eco-friendly processes. It also highlights the preclinical and clinical evidence on phenolic compounds’ antidiabetic activity, giving insight into their mechanisms of action. <b>Conclusions</b>: This review explores the latest advances in polyphenols and how their benefits in glucose homeostasis can be applied toward improving the health of patients with diabetes and related conditions. |
| first_indexed | 2024-03-10T00:47:54Z |
| format | Article |
| id | doaj.art-488f7f4710e141279e0041b2a4a4ceb7 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T00:47:54Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-488f7f4710e141279e0041b2a4a4ceb72023-11-23T14:55:50ZengMDPI AGApplied Sciences2076-34172022-09-011218927110.3390/app12189271Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of DiabetesMarisol Dias0Marina Romaní-Pérez1Aloia Romaní2Aimara de la Cruz3Lorenzo Pastrana4Pablo Fuciños5Isabel R. Amado6INL—International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, PortugalMicrobial Ecology, Nutrition & Health Research Unit, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), 46980 Valencia, SpainChemical Engineering Department, Science Faculty, University of Vigo, 32004 Ourense, SpainDepartment of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading RG6 6A, UKINL—International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, PortugalINL—International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, PortugalINL—International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330 Braga, Portugal<b>Background:</b> Phenolic compounds are food-derived bioactive compounds well-known for their antioxidant and anti-inflammatory properties. They are in the spotlight for the management of diabetes due to their positive effects on glucose homeostasis. <b>Materials and methods:</b> We have performed a literature review on the main topics related to the application of phenolic compounds as functional food ingredients. This includes extraction and purification from vegetable sources and agro-industrial by-products, encapsulation to improve their solubility and bioavailability, and preclinical and clinical evidence linking these compounds with anti-diabetic activity. <b>Objectives:</b> (1) provide an understanding of the role of phenolic compounds on diabetes; (2) identify green technologies for phenolic compounds extraction from agri-food by-products following a biorefinery scheme; (3) underline the relevance of encapsulation techniques using nanotechnology to improve their bioavailability; (4) discuss the therapeutic efficacy of polyphenols. <b>Results</b>: This review compiles recent relevant research on phenolic compounds extraction from renewable resources, their purification from agri-food by-products, and encapsulation strategies using eco-friendly processes. It also highlights the preclinical and clinical evidence on phenolic compounds’ antidiabetic activity, giving insight into their mechanisms of action. <b>Conclusions</b>: This review explores the latest advances in polyphenols and how their benefits in glucose homeostasis can be applied toward improving the health of patients with diabetes and related conditions.https://www.mdpi.com/2076-3417/12/18/9271bioactivesencapsulationgut-brain axisobesityinflammationclinical trials |
| spellingShingle | Marisol Dias Marina Romaní-Pérez Aloia Romaní Aimara de la Cruz Lorenzo Pastrana Pablo Fuciños Isabel R. Amado Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes Applied Sciences bioactives encapsulation gut-brain axis obesity inflammation clinical trials |
| title | Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes |
| title_full | Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes |
| title_fullStr | Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes |
| title_full_unstemmed | Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes |
| title_short | Recent Technological Advances in Phenolic Compounds Recovery and Applications: Source of Nutraceuticals for the Management of Diabetes |
| title_sort | recent technological advances in phenolic compounds recovery and applications source of nutraceuticals for the management of diabetes |
| topic | bioactives encapsulation gut-brain axis obesity inflammation clinical trials |
| url | https://www.mdpi.com/2076-3417/12/18/9271 |
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