Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220304707 |
| _version_ | 1828470250367090688 |
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| author | María Pilar Guallar Rosa Meiriño Carolina Donat-Vargas Octavio Corral Nicolás Jouvé Vicente Soriano |
| author_facet | María Pilar Guallar Rosa Meiriño Carolina Donat-Vargas Octavio Corral Nicolás Jouvé Vicente Soriano |
| author_sort | María Pilar Guallar |
| collection | DOAJ |
| description | A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19. |
| first_indexed | 2024-12-11T04:49:53Z |
| format | Article |
| id | doaj.art-488fab56fe0d4209b29b2a165ad3dc35 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-11T04:49:53Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-488fab56fe0d4209b29b2a165ad3dc352022-12-22T01:20:24ZengElsevierInternational Journal of Infectious Diseases1201-97122020-08-0197290292Inoculum at the time of SARS-CoV-2 exposure and risk of disease severityMaría Pilar Guallar0Rosa Meiriño1Carolina Donat-Vargas2Octavio Corral3Nicolás Jouvé4Vicente Soriano5Department of Preventive Medicine, Public Health & Microbiology. Medical School. Universidad Autónoma de Madrid, Madrid, Spain; IdiPAZ & CIBER Epidemiology & Public Health (CIBERESP) & IMDEA-Food Institute, CEI UAM-CSIC, Madrid, SpainOncology Department, Clínica Universitaria de Navarra, Madrid, SpainDepartment of Preventive Medicine, Public Health & Microbiology. Medical School. Universidad Autónoma de Madrid, Madrid, Spain; Nutritional and Cardiovascular Epidemiology Unit, Environmental Medicine Institute (IMM), Karolinska Institute, Stockholm, SwedenGenetics Department, Alcalá University, Madrid, SpainGenetics Department, Alcalá University, Madrid, SpainMedical Center & Health Sciences School, UNIR, Madrid, Spain; Corresponding author at: UNIR Health Sciences School & Medical Center, Calle Almansa 101, Madrid 28040, Spain.A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19.http://www.sciencedirect.com/science/article/pii/S1201971220304707coronavirusCOVID-19inoculumoutbreaktransmissionepidemiology |
| spellingShingle | María Pilar Guallar Rosa Meiriño Carolina Donat-Vargas Octavio Corral Nicolás Jouvé Vicente Soriano Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity International Journal of Infectious Diseases coronavirus COVID-19 inoculum outbreak transmission epidemiology |
| title | Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity |
| title_full | Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity |
| title_fullStr | Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity |
| title_full_unstemmed | Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity |
| title_short | Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity |
| title_sort | inoculum at the time of sars cov 2 exposure and risk of disease severity |
| topic | coronavirus COVID-19 inoculum outbreak transmission epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220304707 |
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