Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris
Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Ciências
2015-06-01
|
| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200733&lng=en&tlng=en |
| _version_ | 1828159669405745152 |
|---|---|
| author | Luciana M.R. Antinarelli Nícolas C. Pinto Elita Scio Elaine S. Coimbra |
| author_facet | Luciana M.R. Antinarelli Nícolas C. Pinto Elita Scio Elaine S. Coimbra |
| author_sort | Luciana M.R. Antinarelli |
| collection | DOAJ |
| description | Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC50 values below of 20 µg/mL against at least one species of Leishmania. Casearia sylvestris showed the most expressive activity against all promastigote forms of Leishmania species (IC50 values of 5.4 µg/mL, 5.0 µg/mL, 8.5 µg/mL and 7.7 µg/mL for L. amazonensis, L. braziliensis, L. chagasi and L. major, respectively), being more effective than the reference drug miltefosine. In spite of the cytotoxic effect on macrophages (CC50 value of 5.2 µg/mL), C. sylvestris exhibited a strong inhibition against intracellular amastigotes of L. braziliensis (IC50 value of 1.3 µg/mL). Further studies, including bio-guided fractionation will be conducted to identify the active compounds. |
| first_indexed | 2024-04-12T00:04:50Z |
| format | Article |
| id | doaj.art-488fef22ce0f4eb785208af428de1080 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-12T00:04:50Z |
| publishDate | 2015-06-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-488fef22ce0f4eb785208af428de10802022-12-22T03:56:07ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902015-06-0187273374210.1590/0001-3765201520140288S0001-37652015000200733Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestrisLuciana M.R. AntinarelliNícolas C. PintoElita ScioElaine S. CoimbraLeishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC50 values below of 20 µg/mL against at least one species of Leishmania. Casearia sylvestris showed the most expressive activity against all promastigote forms of Leishmania species (IC50 values of 5.4 µg/mL, 5.0 µg/mL, 8.5 µg/mL and 7.7 µg/mL for L. amazonensis, L. braziliensis, L. chagasi and L. major, respectively), being more effective than the reference drug miltefosine. In spite of the cytotoxic effect on macrophages (CC50 value of 5.2 µg/mL), C. sylvestris exhibited a strong inhibition against intracellular amastigotes of L. braziliensis (IC50 value of 1.3 µg/mL). Further studies, including bio-guided fractionation will be conducted to identify the active compounds.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200733&lng=en&tlng=enBrasilCasearia sylvestrisatividade leishmanicidaplantas medicinaisprodutos naturais |
| spellingShingle | Luciana M.R. Antinarelli Nícolas C. Pinto Elita Scio Elaine S. Coimbra Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris Anais da Academia Brasileira de Ciências Brasil Casearia sylvestris atividade leishmanicida plantas medicinais produtos naturais |
| title | Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris |
| title_full | Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris |
| title_fullStr | Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris |
| title_full_unstemmed | Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris |
| title_short | Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris |
| title_sort | antileishmanial activity of some brazilian plants with particular reference to casearia sylvestris |
| topic | Brasil Casearia sylvestris atividade leishmanicida plantas medicinais produtos naturais |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200733&lng=en&tlng=en |
| work_keys_str_mv | AT lucianamrantinarelli antileishmanialactivityofsomebrazilianplantswithparticularreferencetocaseariasylvestris AT nicolascpinto antileishmanialactivityofsomebrazilianplantswithparticularreferencetocaseariasylvestris AT elitascio antileishmanialactivityofsomebrazilianplantswithparticularreferencetocaseariasylvestris AT elainescoimbra antileishmanialactivityofsomebrazilianplantswithparticularreferencetocaseariasylvestris |