Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1
Cigarette smoke exposure is an important factor in chronic inflammation in patients with allergic rhinitis (AR); however, the relationship between cigarette smoke and AR-related glucocorticoid resistance requires further study. In mice, calpeptin significantly reduces inflammation of the lower respi...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023045243 |
| _version_ | 1797771557622251520 |
|---|---|
| author | Wen-Xuan Zhu Yang Xi Fen Li Wo-Er Jiao Zi-Jing Li Shi-Ming Chen Yong-Gang Kong Yu Xu Yu-Qin Deng Jing-Jing Zuo Ze-Zhang Tao |
| author_facet | Wen-Xuan Zhu Yang Xi Fen Li Wo-Er Jiao Zi-Jing Li Shi-Ming Chen Yong-Gang Kong Yu Xu Yu-Qin Deng Jing-Jing Zuo Ze-Zhang Tao |
| author_sort | Wen-Xuan Zhu |
| collection | DOAJ |
| description | Cigarette smoke exposure is an important factor in chronic inflammation in patients with allergic rhinitis (AR); however, the relationship between cigarette smoke and AR-related glucocorticoid resistance requires further study. In mice, calpeptin significantly reduces inflammation of the lower respiratory tract caused by cigarette smoke, but whether it can treat glucocorticoid-resistant AR caused by cigarette smoke requires further research. In this study, we confirmed that cigarette smoke exposure can aggravate the Th2 inflammatory response in AR leading to glucocorticoid resistance. The underlying mechanism may be related to decreased expression of DNA methyltransferase 3a (Dnmt3a), and increased expression of interferon regulatory factor 1 (IRF1). In addition, we found that calpeptin can inhibit the expression of IRF1 and thus treat AR-associated glucocorticoid resistance in rats exposed to cigarette smoke. These data suggest that calpeptin may downregulate IRF1 and therefore treat glucocorticoid resistance in AR-associated with cigarette smoke exposure. |
| first_indexed | 2024-03-12T21:39:19Z |
| format | Article |
| id | doaj.art-48903ad87042464c8b7aa27e95fc09ca |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T21:39:19Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-48903ad87042464c8b7aa27e95fc09ca2023-07-27T05:56:23ZengElsevierHeliyon2405-84402023-07-0197e17316Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1Wen-Xuan Zhu0Yang Xi1Fen Li2Wo-Er Jiao3Zi-Jing Li4Shi-Ming Chen5Yong-Gang Kong6Yu Xu7Yu-Qin Deng8Jing-Jing Zuo9Ze-Zhang Tao10Department of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR ChinaDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR ChinaInstitute of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR ChinaDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR ChinaDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR ChinaDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China; Institute of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR ChinaDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR ChinaDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China; Institute of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR ChinaDepartment of Rhinology and Allergy, Renmin Hospital of Wuhan University, Wuhan, PR ChinaDepartment of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China; Corresponding author. Department of Otolaryngology, Head and Neck Surgery Institute/University/Hospital, Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, PR China.Department of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China; Institute of Otolaryngology, Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, PR China; Department of Rhinology and Allergy, Renmin Hospital of Wuhan University, Wuhan, PR China; Corresponding author. Department of Otolaryngology, Head and Neck Surgery Institute/University/Hospital: Renmin Hospital of Wuhan University, 238 Jie-Fang Road, Wuhan, 430060, Hubei, PR China.Cigarette smoke exposure is an important factor in chronic inflammation in patients with allergic rhinitis (AR); however, the relationship between cigarette smoke and AR-related glucocorticoid resistance requires further study. In mice, calpeptin significantly reduces inflammation of the lower respiratory tract caused by cigarette smoke, but whether it can treat glucocorticoid-resistant AR caused by cigarette smoke requires further research. In this study, we confirmed that cigarette smoke exposure can aggravate the Th2 inflammatory response in AR leading to glucocorticoid resistance. The underlying mechanism may be related to decreased expression of DNA methyltransferase 3a (Dnmt3a), and increased expression of interferon regulatory factor 1 (IRF1). In addition, we found that calpeptin can inhibit the expression of IRF1 and thus treat AR-associated glucocorticoid resistance in rats exposed to cigarette smoke. These data suggest that calpeptin may downregulate IRF1 and therefore treat glucocorticoid resistance in AR-associated with cigarette smoke exposure.http://www.sciencedirect.com/science/article/pii/S2405844023045243Allergic rhinitisCalpeptinCigarette smokeGlucocorticoid resistanceRatsRegulatory factor 1 |
| spellingShingle | Wen-Xuan Zhu Yang Xi Fen Li Wo-Er Jiao Zi-Jing Li Shi-Ming Chen Yong-Gang Kong Yu Xu Yu-Qin Deng Jing-Jing Zuo Ze-Zhang Tao Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 Heliyon Allergic rhinitis Calpeptin Cigarette smoke Glucocorticoid resistance Rats Regulatory factor 1 |
| title | Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 |
| title_full | Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 |
| title_fullStr | Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 |
| title_full_unstemmed | Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 |
| title_short | Calpeptin may reverse glucocorticoid-resistance of allergic rhinitis associated with cigarette smoke exposure by down-regulating interferon regulatory factor 1 |
| title_sort | calpeptin may reverse glucocorticoid resistance of allergic rhinitis associated with cigarette smoke exposure by down regulating interferon regulatory factor 1 |
| topic | Allergic rhinitis Calpeptin Cigarette smoke Glucocorticoid resistance Rats Regulatory factor 1 |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023045243 |
| work_keys_str_mv | AT wenxuanzhu calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT yangxi calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT fenli calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT woerjiao calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT zijingli calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT shimingchen calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT yonggangkong calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT yuxu calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT yuqindeng calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT jingjingzuo calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 AT zezhangtao calpeptinmayreverseglucocorticoidresistanceofallergicrhinitisassociatedwithcigarettesmokeexposurebydownregulatinginterferonregulatoryfactor1 |