Putative Role of <i>MCT1</i> rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus
Monocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La<sup>−</sup>) producer and La<sup>−</sup> recipient (consumer) cells. Previous studies have suggested that the <i>MCT1</i> A1470T genotype could be rel...
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MDPI AG
2021-10-01
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| Series: | Sports |
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| Online Access: | https://www.mdpi.com/2075-4663/9/10/143 |
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| author | Xavier Ramírez de la Piscina-Viúdez Jesús Álvarez-Herms Diego A. Bonilla Arkaitz Castañeda-Babarro Jon Larruskain Julen Díaz-Ramírez Ildus I. Ahmetov Alex Martínez-Ascensión Richard B. Kreider Adrián Odriozola-Martínez |
| author_facet | Xavier Ramírez de la Piscina-Viúdez Jesús Álvarez-Herms Diego A. Bonilla Arkaitz Castañeda-Babarro Jon Larruskain Julen Díaz-Ramírez Ildus I. Ahmetov Alex Martínez-Ascensión Richard B. Kreider Adrián Odriozola-Martínez |
| author_sort | Xavier Ramírez de la Piscina-Viúdez |
| collection | DOAJ |
| description | Monocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La<sup>−</sup>) producer and La<sup>−</sup> recipient (consumer) cells. Previous studies have suggested that the <i>MCT1</i> A1470T genotype could be related to different physical performance phenotypes. This study followed the guidelines for Strengthening the Reporting of Genetic Association Studies (STREGA) and aimed to evaluate the distribution of the <i>MCT1</i> polymorphism rs1049434 in endurance-trained athletes compared to the untrained population. Moreover, this study explored the potential influence of the polymorphism alleles phenotypes on high-intensity exercise performance. In a cross-sectional study fashion, a total of 85 triathletes from northern Spain were genotyped for <i>MCT1</i> rs1049434 and compared to a control group of 107 healthy male participants (1000 Genomes Research Study for Iberian Populations in Spain). All athletes performed a 30 s Wingate all-out test (WAnT) on a cycle ergometer. Peak and mean power (absolute and relative) were measured. After verification of the Hardy–Weinberg equilibrium, the findings indicated that the <i>MCT1</i> TT genotype was overrepresented in triathletes in comparison to the genotypic frequency of the general Spanish population. No significant associations were found between any <i>MCT1</i> genotype and peak or mean power performance in the WAnT. Further studies are required to understand the relationship among <i>MCT1</i> A1470T polymorphism, endurance-trained athletes, and high-intensity performance. |
| first_indexed | 2024-03-10T06:12:14Z |
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| id | doaj.art-4890e16ef5f44538b4f35bdb3d0ad103 |
| institution | Directory Open Access Journal |
| issn | 2075-4663 |
| language | English |
| last_indexed | 2024-03-10T06:12:14Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
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| series | Sports |
| spelling | doaj.art-4890e16ef5f44538b4f35bdb3d0ad1032023-11-22T20:01:36ZengMDPI AGSports2075-46632021-10-0191014310.3390/sports9100143Putative Role of <i>MCT1</i> rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization StimulusXavier Ramírez de la Piscina-Viúdez0Jesús Álvarez-Herms1Diego A. Bonilla2Arkaitz Castañeda-Babarro3Jon Larruskain4Julen Díaz-Ramírez5Ildus I. Ahmetov6Alex Martínez-Ascensión7Richard B. Kreider8Adrián Odriozola-Martínez9Sport Genomics Research Group, Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainSport Genomics Research Group, Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainSport Genomics Research Group, Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainSport Science Research Group, Faculty of Psychology and Education, University of Deusto, 48007 Bilbao, SpainSport Genomics Research Group, Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainSport Genomics Research Group, Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Physical Education, Plekhanov Russian University of Economics, 117997 Moscow, RussiaComputational Biology and Systems Biomedicine Department, Biodonostia Health Research Institute, P/Doctor Begiristain, 20014 Donostia, SpainExercise & Sport Nutrition Laboratory, Human Clinical Research Facility, Texas A&M University, College Station, TX 77843, USASport Genomics Research Group, Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainMonocarboxylate transporters (MCTs) have been proposed as important mediators of the exchange between lactate (La<sup>−</sup>) producer and La<sup>−</sup> recipient (consumer) cells. Previous studies have suggested that the <i>MCT1</i> A1470T genotype could be related to different physical performance phenotypes. This study followed the guidelines for Strengthening the Reporting of Genetic Association Studies (STREGA) and aimed to evaluate the distribution of the <i>MCT1</i> polymorphism rs1049434 in endurance-trained athletes compared to the untrained population. Moreover, this study explored the potential influence of the polymorphism alleles phenotypes on high-intensity exercise performance. In a cross-sectional study fashion, a total of 85 triathletes from northern Spain were genotyped for <i>MCT1</i> rs1049434 and compared to a control group of 107 healthy male participants (1000 Genomes Research Study for Iberian Populations in Spain). All athletes performed a 30 s Wingate all-out test (WAnT) on a cycle ergometer. Peak and mean power (absolute and relative) were measured. After verification of the Hardy–Weinberg equilibrium, the findings indicated that the <i>MCT1</i> TT genotype was overrepresented in triathletes in comparison to the genotypic frequency of the general Spanish population. No significant associations were found between any <i>MCT1</i> genotype and peak or mean power performance in the WAnT. Further studies are required to understand the relationship among <i>MCT1</i> A1470T polymorphism, endurance-trained athletes, and high-intensity performance.https://www.mdpi.com/2075-4663/9/10/143lactategeneticsendurancemetabolismmusculoskeletalperformance |
| spellingShingle | Xavier Ramírez de la Piscina-Viúdez Jesús Álvarez-Herms Diego A. Bonilla Arkaitz Castañeda-Babarro Jon Larruskain Julen Díaz-Ramírez Ildus I. Ahmetov Alex Martínez-Ascensión Richard B. Kreider Adrián Odriozola-Martínez Putative Role of <i>MCT1</i> rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus Sports lactate genetics endurance metabolism musculoskeletal performance |
| title | Putative Role of <i>MCT1</i> rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus |
| title_full | Putative Role of <i>MCT1</i> rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus |
| title_fullStr | Putative Role of <i>MCT1</i> rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus |
| title_full_unstemmed | Putative Role of <i>MCT1</i> rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus |
| title_short | Putative Role of <i>MCT1</i> rs1049434 Polymorphism in High-Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus |
| title_sort | putative role of i mct1 i rs1049434 polymorphism in high intensity endurance performance concept and basis to understand possible individualization stimulus |
| topic | lactate genetics endurance metabolism musculoskeletal performance |
| url | https://www.mdpi.com/2075-4663/9/10/143 |
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