Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysis
Introduction: The efficacy of low-intensity blood flow restriction (LI-BFR) training programs in bone metabolism remains unclear compared to low-intensity (LI) training and high-intensity (HI) training. The aim of this review was to quantitatively identify the effects of LI-BFR training on changes i...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1212927/full |
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| author | Xiaolin Wang Yifei Wang Xuezhen Yang Nasnoor Juzaily Bin Mohd Nasiruddin Delong Dong Shamsulariffin Bin Samsudin Xin-Min Qin |
| author_facet | Xiaolin Wang Yifei Wang Xuezhen Yang Nasnoor Juzaily Bin Mohd Nasiruddin Delong Dong Shamsulariffin Bin Samsudin Xin-Min Qin |
| author_sort | Xiaolin Wang |
| collection | DOAJ |
| description | Introduction: The efficacy of low-intensity blood flow restriction (LI-BFR) training programs in bone metabolism remains unclear compared to low-intensity (LI) training and high-intensity (HI) training. The aim of this review was to quantitatively identify the effects of LI-BFR training on changes in bone formation markers (i.e., bone-specific alkaline phosphatase, BALP), bone resorption (i.e., C-terminal telopeptide of type I collagen, CTX) and bone mineral density (BMD) compared with conventional resistance training programmes. Additionally, the effectiveness of walking with and without BFR was assessed.Methods: PubMed, Scopus, SPORTDiscus, Web of Science and Google Scholar databases were searched for articles based on eligibility criteria. Review Manager Version 5.4 was used for Meta-analysis. Physiotherapy Evidence Database (PEDro) was applied to assess the methodological quality of studies.Results: 12 articles were included in the meta-analysis, with a total of 378 participants. Meta-results showed that compared with LI training, LI-BFR training induced greater increments in BALP (young adults: MD = 6.70, p < 0.001; old adults: MD = 3.94, p = 0.002), slight increments in BMD (young adults: MD = 0.05, p < 0.00001; old adults: MD = 0.01, p < 0.00001), and greater decrements in CTX (young adults: MD = −0.19, p = 0.15; old adults: MD = −0.07, p = 0.003). Compared with HI training, LI-BFR training produced smaller increments in BALP (young adults: MD = −6.87, p = 0.24; old adults: MD = −0.6, p = 0.58), similar increments in BMD (MD = −0.01, p = 0.76) and similar decrements in CTX (young adults: MD = 0, p = 0.96; old adults: MD = −0.08, p = 0.13). Although there were only two studies on walking training intervention, walking training with BFR had a better effect on bone metabolism than training without BFR.Discussion: In conclusion, LI-BFR training induces greater improvements in bone health than LI training, but is less effective than HI training. Therefore, LI-BFR training may be an effective and efficient way to improve bone health for untrained individuals, older adults, or those undergoing musculoskeletal rehabilitation.Clinical Trial Registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42023411837]. |
| first_indexed | 2024-03-12T16:10:20Z |
| format | Article |
| id | doaj.art-48911820e791425cad361905548ad384 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-12T16:10:20Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-48911820e791425cad361905548ad3842023-08-09T13:43:53ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-08-011410.3389/fphys.2023.12129271212927Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysisXiaolin Wang0Yifei Wang1Xuezhen Yang2Nasnoor Juzaily Bin Mohd Nasiruddin3Delong Dong4Shamsulariffin Bin Samsudin5Xin-Min Qin6Department of Sport Studies, Faculty of Educational Studies, University Putra Malaysia, Serdang, Selangor, MalaysiaDepartment of Physical Education, Ludong University, Yantai, ChinaSchool of Nursing, Shandong First Medical University, Jinan, ChinaDepartment of Sport Studies, Faculty of Educational Studies, University Putra Malaysia, Serdang, Selangor, MalaysiaDepartment of Physical Education, Ludong University, Yantai, ChinaDepartment of Sport Studies, Faculty of Educational Studies, University Putra Malaysia, Serdang, Selangor, MalaysiaDepartment of Smart Health Science and Technology Convergence (Sport Science), Department of Sport Science, Kangwon National University, Chuncheon, Republic of KoreaIntroduction: The efficacy of low-intensity blood flow restriction (LI-BFR) training programs in bone metabolism remains unclear compared to low-intensity (LI) training and high-intensity (HI) training. The aim of this review was to quantitatively identify the effects of LI-BFR training on changes in bone formation markers (i.e., bone-specific alkaline phosphatase, BALP), bone resorption (i.e., C-terminal telopeptide of type I collagen, CTX) and bone mineral density (BMD) compared with conventional resistance training programmes. Additionally, the effectiveness of walking with and without BFR was assessed.Methods: PubMed, Scopus, SPORTDiscus, Web of Science and Google Scholar databases were searched for articles based on eligibility criteria. Review Manager Version 5.4 was used for Meta-analysis. Physiotherapy Evidence Database (PEDro) was applied to assess the methodological quality of studies.Results: 12 articles were included in the meta-analysis, with a total of 378 participants. Meta-results showed that compared with LI training, LI-BFR training induced greater increments in BALP (young adults: MD = 6.70, p < 0.001; old adults: MD = 3.94, p = 0.002), slight increments in BMD (young adults: MD = 0.05, p < 0.00001; old adults: MD = 0.01, p < 0.00001), and greater decrements in CTX (young adults: MD = −0.19, p = 0.15; old adults: MD = −0.07, p = 0.003). Compared with HI training, LI-BFR training produced smaller increments in BALP (young adults: MD = −6.87, p = 0.24; old adults: MD = −0.6, p = 0.58), similar increments in BMD (MD = −0.01, p = 0.76) and similar decrements in CTX (young adults: MD = 0, p = 0.96; old adults: MD = −0.08, p = 0.13). Although there were only two studies on walking training intervention, walking training with BFR had a better effect on bone metabolism than training without BFR.Discussion: In conclusion, LI-BFR training induces greater improvements in bone health than LI training, but is less effective than HI training. Therefore, LI-BFR training may be an effective and efficient way to improve bone health for untrained individuals, older adults, or those undergoing musculoskeletal rehabilitation.Clinical Trial Registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42023411837].https://www.frontiersin.org/articles/10.3389/fphys.2023.1212927/fullblood flow restriction trainingocclusion trainingosteogenesisischaemiatherapeutic occlusion |
| spellingShingle | Xiaolin Wang Yifei Wang Xuezhen Yang Nasnoor Juzaily Bin Mohd Nasiruddin Delong Dong Shamsulariffin Bin Samsudin Xin-Min Qin Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysis Frontiers in Physiology blood flow restriction training occlusion training osteogenesis ischaemia therapeutic occlusion |
| title | Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysis |
| title_full | Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysis |
| title_fullStr | Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysis |
| title_full_unstemmed | Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysis |
| title_short | Effects of blood flow restriction training on bone metabolism: a systematic review and meta-analysis |
| title_sort | effects of blood flow restriction training on bone metabolism a systematic review and meta analysis |
| topic | blood flow restriction training occlusion training osteogenesis ischaemia therapeutic occlusion |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1212927/full |
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