Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was acce...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Psiquiatria (ABP)
2016-01-01
|
| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016005005103&lng=en&tlng=en |
| _version_ | 1819037670925402112 |
|---|---|
| author | Mirela P. Vasconcelos-Moreno Joana Bücker Kelen P. Bürke Leticia Czepielewski Barbara T. Santos Adam Fijtman Ives C. Passos Mauricio Kunz Caterina del Mar Bonnín Eduard Vieta Flavio Kapczinski Adriane R. Rosa Marcia Kauer-Sant’Anna |
| author_facet | Mirela P. Vasconcelos-Moreno Joana Bücker Kelen P. Bürke Leticia Czepielewski Barbara T. Santos Adam Fijtman Ives C. Passos Mauricio Kunz Caterina del Mar Bonnín Eduard Vieta Flavio Kapczinski Adriane R. Rosa Marcia Kauer-Sant’Anna |
| author_sort | Mirela P. Vasconcelos-Moreno |
| collection | DOAJ |
| description | Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations. |
| first_indexed | 2024-12-21T08:25:07Z |
| format | Article |
| id | doaj.art-489246b48fbe49db9447044373f4cf6e |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-12-21T08:25:07Z |
| publishDate | 2016-01-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-489246b48fbe49db9447044373f4cf6e2022-12-21T19:10:20ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2016-01-01010.1590/1516-4446-2015-1868S1516-44462016005005103Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controlsMirela P. Vasconcelos-MorenoJoana BückerKelen P. BürkeLeticia CzepielewskiBarbara T. SantosAdam FijtmanIves C. PassosMauricio KunzCaterina del Mar BonnínEduard VietaFlavio KapczinskiAdriane R. RosaMarcia Kauer-Sant’AnnaObjective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016005005103&lng=en&tlng=enBipolar disordersiblingsfunctional impairmentcognitionendophenotype |
| spellingShingle | Mirela P. Vasconcelos-Moreno Joana Bücker Kelen P. Bürke Leticia Czepielewski Barbara T. Santos Adam Fijtman Ives C. Passos Mauricio Kunz Caterina del Mar Bonnín Eduard Vieta Flavio Kapczinski Adriane R. Rosa Marcia Kauer-Sant’Anna Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls Brazilian Journal of Psychiatry Bipolar disorder siblings functional impairment cognition endophenotype |
| title | Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_full | Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_fullStr | Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_full_unstemmed | Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_short | Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls |
| title_sort | cognitive performance and psychosocial functioning in patients with bipolar disorder unaffected siblings and healthy controls |
| topic | Bipolar disorder siblings functional impairment cognition endophenotype |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462016005005103&lng=en&tlng=en |
| work_keys_str_mv | AT mirelapvasconcelosmoreno cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT joanabucker cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT kelenpburke cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT leticiaczepielewski cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT barbaratsantos cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT adamfijtman cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT ivescpassos cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT mauriciokunz cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT caterinadelmarbonnin cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT eduardvieta cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT flaviokapczinski cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT adrianerrosa cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols AT marciakauersantanna cognitiveperformanceandpsychosocialfunctioninginpatientswithbipolardisorderunaffectedsiblingsandhealthycontrols |