Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics

Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics

Abstract Objective This article describes in vitro and in vivo studies that aimed to further characterize the biopharmaceutical properties and pharmacokinetic (PK) profile of vericiguat and to guide dosing recommendations. Methods Five open-label, phase I studies characterized the biopharmaceutical...

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Bibliographic Details
Main Authors: Corina Becker, Michael Boettcher, Uwe Muenster, Stephanie Loewen, Maximilian Lobmeyer, Wolfgang Mueck
Format: Article
Language:English
Published: SpringerOpen 2022-11-01
Series:AAPS Open
Subjects:
Crushed
Dissolution
Heart failure
Dose proportionality
Bioavailability
Online Access:https://doi.org/10.1186/s41120-022-00063-4

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