Uncovering the functional anatomy of the human insula during speech
The contribution of insular cortex to speech production remains unclear and controversial given diverse findings from functional neuroimaging and lesional data. To create a precise spatiotemporal map of insular activity, we performed a series of experiments: single-word articulations of varying comp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/53086 |
| _version_ | 1811228112294248448 |
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| author | Oscar Woolnough Kiefer James Forseth Patrick Sarahan Rollo Nitin Tandon |
| author_facet | Oscar Woolnough Kiefer James Forseth Patrick Sarahan Rollo Nitin Tandon |
| author_sort | Oscar Woolnough |
| collection | DOAJ |
| description | The contribution of insular cortex to speech production remains unclear and controversial given diverse findings from functional neuroimaging and lesional data. To create a precise spatiotemporal map of insular activity, we performed a series of experiments: single-word articulations of varying complexity, non-speech orofacial movements and speech listening, in a cohort of 27 patients implanted with penetrating intracranial electrodes. The posterior insula was robustly active bilaterally, but after the onset of articulation, during listening to speech and during production of non-speech mouth movements. Preceding articulation there was very sparse activity, localized primarily to the frontal operculum rather than the insula. Posterior insular was active coincident with superior temporal gyrus but was more active for self-generated speech than external speech, the opposite of the superior temporal gyrus. These findings support the conclusion that the insula does not serve pre-articulatory preparatory roles. |
| first_indexed | 2024-04-12T09:53:00Z |
| format | Article |
| id | doaj.art-4892aa320b664cf78803c8845d90b795 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:53:00Z |
| publishDate | 2019-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4892aa320b664cf78803c8845d90b7952022-12-22T03:37:47ZengeLife Sciences Publications LtdeLife2050-084X2019-12-01810.7554/eLife.53086Uncovering the functional anatomy of the human insula during speechOscar Woolnough0https://orcid.org/0000-0002-5878-6865Kiefer James Forseth1https://orcid.org/0000-0003-1624-8329Patrick Sarahan Rollo2Nitin Tandon3https://orcid.org/0000-0002-2752-2365Vivian L. Smith Department of Neurosurgery, McGovern Medical School at UT Health Houston, Houston, United States; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, United StatesVivian L. Smith Department of Neurosurgery, McGovern Medical School at UT Health Houston, Houston, United States; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, United StatesVivian L. Smith Department of Neurosurgery, McGovern Medical School at UT Health Houston, Houston, United States; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, United StatesVivian L. Smith Department of Neurosurgery, McGovern Medical School at UT Health Houston, Houston, United States; Texas Institute for Restorative Neurotechnologies, University of Texas Health Science Center at Houston, Houston, United States; Memorial Hermann Hospital, Texas Medical Center, Houston, United StatesThe contribution of insular cortex to speech production remains unclear and controversial given diverse findings from functional neuroimaging and lesional data. To create a precise spatiotemporal map of insular activity, we performed a series of experiments: single-word articulations of varying complexity, non-speech orofacial movements and speech listening, in a cohort of 27 patients implanted with penetrating intracranial electrodes. The posterior insula was robustly active bilaterally, but after the onset of articulation, during listening to speech and during production of non-speech mouth movements. Preceding articulation there was very sparse activity, localized primarily to the frontal operculum rather than the insula. Posterior insular was active coincident with superior temporal gyrus but was more active for self-generated speech than external speech, the opposite of the superior temporal gyrus. These findings support the conclusion that the insula does not serve pre-articulatory preparatory roles.https://elifesciences.org/articles/53086insulaapraxia of speechStereoelectroencephalographyintracranial recordingspeech productionspeech perception |
| spellingShingle | Oscar Woolnough Kiefer James Forseth Patrick Sarahan Rollo Nitin Tandon Uncovering the functional anatomy of the human insula during speech eLife insula apraxia of speech Stereoelectroencephalography intracranial recording speech production speech perception |
| title | Uncovering the functional anatomy of the human insula during speech |
| title_full | Uncovering the functional anatomy of the human insula during speech |
| title_fullStr | Uncovering the functional anatomy of the human insula during speech |
| title_full_unstemmed | Uncovering the functional anatomy of the human insula during speech |
| title_short | Uncovering the functional anatomy of the human insula during speech |
| title_sort | uncovering the functional anatomy of the human insula during speech |
| topic | insula apraxia of speech Stereoelectroencephalography intracranial recording speech production speech perception |
| url | https://elifesciences.org/articles/53086 |
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