A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones
ObjectivesNon-alcoholic fatty liver disease (NAFLD) has been linked to an increased risk of kidney stones in prior observational studies, However, the results are inconsistent, and the causality remains to be established. We aimed to investigate the potential causal relationship between NAFLD and ki...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1343367/full |
| _version_ | 1797359198365810688 |
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| author | Xintao Li Xintao Li Xintao Li Yongpeng Xie Lu Tang Di Li Jun Wang Haibo Sheng Kaikai Chen Shuwei Xiao Jianye Li Minghui Yang |
| author_facet | Xintao Li Xintao Li Xintao Li Yongpeng Xie Lu Tang Di Li Jun Wang Haibo Sheng Kaikai Chen Shuwei Xiao Jianye Li Minghui Yang |
| author_sort | Xintao Li |
| collection | DOAJ |
| description | ObjectivesNon-alcoholic fatty liver disease (NAFLD) has been linked to an increased risk of kidney stones in prior observational studies, However, the results are inconsistent, and the causality remains to be established. We aimed to investigate the potential causal relationship between NAFLD and kidney stones using two-sample Mendelian randomization (MR).MethodsGenetic instruments were used as proxies for NAFLD. Summary-level data for the associations of exposure-associated SNPs with kidney stones were obtained from the UK Biobank study (6536 cases and 388,508 controls) and the FinnGen consortium (9713 cases and 366,693 non-cases). MR methods were conducted, including inverse variance weighted method (IVW), MR-Egger, weighted median, and MR-PRESSO. MR-Egger Regression Intercept and Cochran’s Q test were used to assess the directional pleiotropy and heterogeneity.ResultscALT-associated NAFLD did not exhibit an association with kidney stones in the Inverse variance weighted (IVW) methods, in both the FinnGen consortium (OR: 1.02, 95%CI: 0.94-1.11, p = 0.632) and the UKBB study (OR: 1.000, 95%CI: 0.998-1.002, p = 0.852). The results were consistent in European ancestry (FinnGen OR: 1.05, 95%CI: 0.98-1.14, p = 0.144, UKBB OR: 1.000, 95%CI: 0.998-1.002, p = 0.859). IVW MR analysis also did not reveal a significant causal relationship between NAFLD and the risk of kidney stone for the other three NAFLD-related traits, including imaging-based, biopsy-confirmed NAFLD, and more stringent biopsy-confirmed NAFLD. The results remained consistent and robust in the sensitivity analysis.ConclusionsThe MR study did not provide sufficient evidence to support the causal associations of NAFLD with kidney stones. |
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| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T15:13:16Z |
| publishDate | 2024-01-01 |
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| spelling | doaj.art-4893bd3d8d5b4a118154918fa9036c7b2024-01-10T14:07:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.13433671343367A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stonesXintao Li0Xintao Li1Xintao Li2Yongpeng Xie3Lu Tang4Di Li5Jun Wang6Haibo Sheng7Kaikai Chen8Shuwei Xiao9Jianye Li10Minghui Yang11Department of Traditional Chinese Medicine, The Sixth Medical Centre, Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Urology, The Third Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Urology, Air Force Medical Center, Air Force Medical University, Beijing, ChinaDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Urology, The Third Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, ChinaDepartment of Urology, Air Force Medical Center, Air Force Medical University, Beijing, ChinaDepartment of Urology, Air Force Medical Center, Air Force Medical University, Beijing, ChinaDepartment of Urology, Air Force Medical Center, Air Force Medical University, Beijing, ChinaDepartment of Urology, Air Force Medical Center, Air Force Medical University, Beijing, ChinaDepartment of Urology, Air Force Medical Center, Air Force Medical University, Beijing, ChinaDepartment of Urology, Air Force Medical Center, Air Force Medical University, Beijing, ChinaDepartment of Traditional Chinese Medicine, The Sixth Medical Centre, Chinese People’s Liberation Army General Hospital, Beijing, ChinaObjectivesNon-alcoholic fatty liver disease (NAFLD) has been linked to an increased risk of kidney stones in prior observational studies, However, the results are inconsistent, and the causality remains to be established. We aimed to investigate the potential causal relationship between NAFLD and kidney stones using two-sample Mendelian randomization (MR).MethodsGenetic instruments were used as proxies for NAFLD. Summary-level data for the associations of exposure-associated SNPs with kidney stones were obtained from the UK Biobank study (6536 cases and 388,508 controls) and the FinnGen consortium (9713 cases and 366,693 non-cases). MR methods were conducted, including inverse variance weighted method (IVW), MR-Egger, weighted median, and MR-PRESSO. MR-Egger Regression Intercept and Cochran’s Q test were used to assess the directional pleiotropy and heterogeneity.ResultscALT-associated NAFLD did not exhibit an association with kidney stones in the Inverse variance weighted (IVW) methods, in both the FinnGen consortium (OR: 1.02, 95%CI: 0.94-1.11, p = 0.632) and the UKBB study (OR: 1.000, 95%CI: 0.998-1.002, p = 0.852). The results were consistent in European ancestry (FinnGen OR: 1.05, 95%CI: 0.98-1.14, p = 0.144, UKBB OR: 1.000, 95%CI: 0.998-1.002, p = 0.859). IVW MR analysis also did not reveal a significant causal relationship between NAFLD and the risk of kidney stone for the other three NAFLD-related traits, including imaging-based, biopsy-confirmed NAFLD, and more stringent biopsy-confirmed NAFLD. The results remained consistent and robust in the sensitivity analysis.ConclusionsThe MR study did not provide sufficient evidence to support the causal associations of NAFLD with kidney stones.https://www.frontiersin.org/articles/10.3389/fendo.2023.1343367/fullNAFLDkidney stoneMendelian randomizationcausalitygenome wide association study |
| spellingShingle | Xintao Li Xintao Li Xintao Li Yongpeng Xie Lu Tang Di Li Jun Wang Haibo Sheng Kaikai Chen Shuwei Xiao Jianye Li Minghui Yang A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones Frontiers in Endocrinology NAFLD kidney stone Mendelian randomization causality genome wide association study |
| title | A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones |
| title_full | A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones |
| title_fullStr | A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones |
| title_full_unstemmed | A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones |
| title_short | A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones |
| title_sort | two sample mendelian randomization analysis excludes causal relationships between non alcoholic fatty liver disease and kidney stones |
| topic | NAFLD kidney stone Mendelian randomization causality genome wide association study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1343367/full |
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