The unattainable criteria for new infant vaccines
Background. In 2013, the US Advisory Committee on Immunization Practices (ACIP) opted against adding meningococcal vaccines to the infant schedule due to poor cost-effectiveness. This raises a policy question: if meningococcal disease is too rare to justify routine vaccination, are there other vacci...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1328334 |
| _version_ | 1827810011582038016 |
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| author | Christopher J. Gill Lauren Hodsdon Mathuram Santosham Katherine L. O'Brien |
| author_facet | Christopher J. Gill Lauren Hodsdon Mathuram Santosham Katherine L. O'Brien |
| author_sort | Christopher J. Gill |
| collection | DOAJ |
| description | Background. In 2013, the US Advisory Committee on Immunization Practices (ACIP) opted against adding meningococcal vaccines to the infant schedule due to poor cost-effectiveness. This raises a policy question: if meningococcal disease is too rare to justify routine vaccination, are there other vaccine-preventable causes of US infant deaths that could be supported? Methods. We tabulated US infant deaths from 2009–2013 using the CDC WONDER database. These causes of death were then categorized into one of 3 categories: 1) vaccine-preventable using currently available interventions; 2) potentially vaccine-preventable within the next 10 years; and 3) not preventable. Results. From 19.8 million births (3.9 million/year), ∼122,000 infants died (0.62%). Of these, 181 (0.15% of all deaths) were preventable using currently available vaccines, while an additional 779 were categorized as potentially preventable in the next 10 y. By exclusion, 121,040 (99.2%) were judged ‘not vaccine-preventable’. Meningococcal deaths contributed at most 0.03% of all infant deaths, but accounted for 17–34% of current vaccine-preventable deaths. Conclusions. The low number of vaccine-preventable deaths in the US makes it increasingly difficult to justify the introduction of any new infant vaccines. |
| first_indexed | 2024-03-11T22:46:38Z |
| format | Article |
| id | doaj.art-4893ebd560ad4395b52de624a762428f |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:46:38Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-4893ebd560ad4395b52de624a762428f2023-09-22T08:17:50ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-05-011451179118710.1080/21645515.2017.13283341328334The unattainable criteria for new infant vaccinesChristopher J. Gill0Lauren Hodsdon1Mathuram Santosham2Katherine L. O'Brien3Boston University School of Public HealthBoston University School of Public HealthJohns Hopkins School of Public HealthJohns Hopkins School of Public HealthBackground. In 2013, the US Advisory Committee on Immunization Practices (ACIP) opted against adding meningococcal vaccines to the infant schedule due to poor cost-effectiveness. This raises a policy question: if meningococcal disease is too rare to justify routine vaccination, are there other vaccine-preventable causes of US infant deaths that could be supported? Methods. We tabulated US infant deaths from 2009–2013 using the CDC WONDER database. These causes of death were then categorized into one of 3 categories: 1) vaccine-preventable using currently available interventions; 2) potentially vaccine-preventable within the next 10 years; and 3) not preventable. Results. From 19.8 million births (3.9 million/year), ∼122,000 infants died (0.62%). Of these, 181 (0.15% of all deaths) were preventable using currently available vaccines, while an additional 779 were categorized as potentially preventable in the next 10 y. By exclusion, 121,040 (99.2%) were judged ‘not vaccine-preventable’. Meningococcal deaths contributed at most 0.03% of all infant deaths, but accounted for 17–34% of current vaccine-preventable deaths. Conclusions. The low number of vaccine-preventable deaths in the US makes it increasingly difficult to justify the introduction of any new infant vaccines.http://dx.doi.org/10.1080/21645515.2017.1328334acipcost-effectivenessinfant mortalitymeningitismeningococcal vaccinevaccines |
| spellingShingle | Christopher J. Gill Lauren Hodsdon Mathuram Santosham Katherine L. O'Brien The unattainable criteria for new infant vaccines Human Vaccines & Immunotherapeutics acip cost-effectiveness infant mortality meningitis meningococcal vaccine vaccines |
| title | The unattainable criteria for new infant vaccines |
| title_full | The unattainable criteria for new infant vaccines |
| title_fullStr | The unattainable criteria for new infant vaccines |
| title_full_unstemmed | The unattainable criteria for new infant vaccines |
| title_short | The unattainable criteria for new infant vaccines |
| title_sort | unattainable criteria for new infant vaccines |
| topic | acip cost-effectiveness infant mortality meningitis meningococcal vaccine vaccines |
| url | http://dx.doi.org/10.1080/21645515.2017.1328334 |
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