Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom Disorder
ObjectiveRecent studies have revealed a strong association between the cerebellum and psychiatric disorders. However, the structural changes in the cerebellar regions and functional connectivity (FC) patterns in patients with somatic symptom disorder (SSD) have not been elucidated.MethodsThirty-seve...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.816435/full |
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| author | Huai-Bin Liang Liao Dong Yangyang Cui Jing Wu Wei Tang Xiaoxia Du Xiaoxia Du Jian-Ren Liu Jian-Ren Liu |
| author_facet | Huai-Bin Liang Liao Dong Yangyang Cui Jing Wu Wei Tang Xiaoxia Du Xiaoxia Du Jian-Ren Liu Jian-Ren Liu |
| author_sort | Huai-Bin Liang |
| collection | DOAJ |
| description | ObjectiveRecent studies have revealed a strong association between the cerebellum and psychiatric disorders. However, the structural changes in the cerebellar regions and functional connectivity (FC) patterns in patients with somatic symptom disorder (SSD) have not been elucidated.MethodsThirty-seven patients with SSD (29 drug-naive and 8 medicated patients) and 37 sex- and age-matched healthy controls (HCs) were recruited and underwent resting-state functional magnetic resonance imaging scans. The spatially unbiased infratentorial (SUIT) cerebellar atlas-based voxel-based morphometry was used to investigate the changes in cerebellar regional gray matter (GM). Seed-based FC was further computed to explore the pattern of abnormal FC across the whole brain. Correlations were calculated to investigate the relationship between cerebellar structural (and FC) changes and clinical characteristics.ResultsAfter controlling for age, sex, total intracranial volume, medication, and mean FD covariates, all patients with SSD had increased mean GM volume (GMV) in the posterior lobules of the cerebellum bilaterally when compared with HCs, specifically, in the bilateral cerebellar crura I and II. Patients with SSD showed significantly stronger FC between the right crura I and II and bilateral precuneus inferior parietal region, and postcentral gyrus, extending to the superior parietal lobe, cingulate gyrus, and the white matter subgyral. In addition to the two clusters, right lingual gyrus was also a surviving cluster with significantly higher FC. Partial correlation analysis revealed that the degree of regional GMV increases in the two significant clusters and the Hamilton Depression Scale (HAMD) score was negatively correlated. Moreover, the FC of right crura I and II with the left parietal lobe and right lingual gyrus were also negatively associated with the HAMD score.ConclusionsSSD exhibited significant microstructural changes and changes in FC pattern in the posterior cerebellar lobe. These results shed new light on the psychological and neural substrates of SSD and may serve as a potential treatment target for SSD based on the cerebellar area. |
| first_indexed | 2024-12-22T05:54:36Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-22T05:54:36Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-4894805b80124129a69e21e056cab9862022-12-21T18:36:45ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-03-011610.3389/fnins.2022.816435816435Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom DisorderHuai-Bin Liang0Liao Dong1Yangyang Cui2Jing Wu3Wei Tang4Xiaoxia Du5Xiaoxia Du6Jian-Ren Liu7Jian-Ren Liu8Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Magnetic Resonance, Department of Physics, School of Physics and Electronic Science, East China Normal University, Shanghai, ChinaShanghai Key Laboratory of Magnetic Resonance, Department of Physics, School of Physics and Electronic Science, East China Normal University, Shanghai, ChinaDepartment of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Magnetic Resonance, Department of Physics, School of Physics and Electronic Science, East China Normal University, Shanghai, ChinaShanghai Key Laboratory of Magnetic Resonance, Department of Physics, School of Physics and Electronic Science, East China Normal University, Shanghai, ChinaSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaDepartment of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaClinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjectiveRecent studies have revealed a strong association between the cerebellum and psychiatric disorders. However, the structural changes in the cerebellar regions and functional connectivity (FC) patterns in patients with somatic symptom disorder (SSD) have not been elucidated.MethodsThirty-seven patients with SSD (29 drug-naive and 8 medicated patients) and 37 sex- and age-matched healthy controls (HCs) were recruited and underwent resting-state functional magnetic resonance imaging scans. The spatially unbiased infratentorial (SUIT) cerebellar atlas-based voxel-based morphometry was used to investigate the changes in cerebellar regional gray matter (GM). Seed-based FC was further computed to explore the pattern of abnormal FC across the whole brain. Correlations were calculated to investigate the relationship between cerebellar structural (and FC) changes and clinical characteristics.ResultsAfter controlling for age, sex, total intracranial volume, medication, and mean FD covariates, all patients with SSD had increased mean GM volume (GMV) in the posterior lobules of the cerebellum bilaterally when compared with HCs, specifically, in the bilateral cerebellar crura I and II. Patients with SSD showed significantly stronger FC between the right crura I and II and bilateral precuneus inferior parietal region, and postcentral gyrus, extending to the superior parietal lobe, cingulate gyrus, and the white matter subgyral. In addition to the two clusters, right lingual gyrus was also a surviving cluster with significantly higher FC. Partial correlation analysis revealed that the degree of regional GMV increases in the two significant clusters and the Hamilton Depression Scale (HAMD) score was negatively correlated. Moreover, the FC of right crura I and II with the left parietal lobe and right lingual gyrus were also negatively associated with the HAMD score.ConclusionsSSD exhibited significant microstructural changes and changes in FC pattern in the posterior cerebellar lobe. These results shed new light on the psychological and neural substrates of SSD and may serve as a potential treatment target for SSD based on the cerebellar area.https://www.frontiersin.org/articles/10.3389/fnins.2022.816435/fullvoxel-based morphometry (VBM)functional connectivity (FC)cerebellumsomatic symptom disorder (SSD)gray matter volume (GMV) |
| spellingShingle | Huai-Bin Liang Liao Dong Yangyang Cui Jing Wu Wei Tang Xiaoxia Du Xiaoxia Du Jian-Ren Liu Jian-Ren Liu Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom Disorder Frontiers in Neuroscience voxel-based morphometry (VBM) functional connectivity (FC) cerebellum somatic symptom disorder (SSD) gray matter volume (GMV) |
| title | Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom Disorder |
| title_full | Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom Disorder |
| title_fullStr | Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom Disorder |
| title_full_unstemmed | Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom Disorder |
| title_short | Significant Structural Alterations and Functional Connectivity Alterations of Cerebellar Gray Matter in Patients With Somatic Symptom Disorder |
| title_sort | significant structural alterations and functional connectivity alterations of cerebellar gray matter in patients with somatic symptom disorder |
| topic | voxel-based morphometry (VBM) functional connectivity (FC) cerebellum somatic symptom disorder (SSD) gray matter volume (GMV) |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.816435/full |
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