Key elements of psoriasis immunogenetics: A review
Psoriasis is one of the most common skin diseases, affecting 2% to 3% of the world population. It occurs at any stage of life. “Early” psoriasis or type I manifests before 40 years, and “late” psoriasis or type II, after 40 years. It has a strong genetic basis and the probability of inheriting the d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Spanish |
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Universidad de Antioquia
2014-10-01
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| Series: | Iatreia |
| Subjects: | |
| Online Access: | http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/17323/17397 |
| _version_ | 1818845899586011136 |
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| author | Duque Cardona, Leidy Yohana Sotelo Tascón, Jared Velásquez Lopera, Margarita María |
| author_facet | Duque Cardona, Leidy Yohana Sotelo Tascón, Jared Velásquez Lopera, Margarita María |
| author_sort | Duque Cardona, Leidy Yohana |
| collection | DOAJ |
| description | Psoriasis is one of the most common skin diseases, affecting 2% to 3% of the world population. It occurs at any stage of life. “Early” psoriasis or type I manifests before 40 years, and “late” psoriasis or type II, after 40 years. It has a strong genetic basis and the probability of inheriting the disease when both parents are affected is up to 50%. Different susceptibility regions associated with psoriasis, called PSORS, have been described, PSORS-1 being the most frequent one. It is in chromosome 6 and in this region HLA-Cw6 is located, which is until now the gene more associated with psoriasis. The role of HLA-Cw6 in psoriasis is not fully understood, but it has a relationship with type I psoriasis, guttate psoriasis and presentation of an array of antigens including those derived from Streptococcus pyogenes. Furthermore, some single nucleotide polymorphisms in genes encoding cytokines such as IL-12, IL-23, TNF-α or its receptors are associated with the immunopathogenesis of the disease. |
| first_indexed | 2024-12-19T05:36:59Z |
| format | Article |
| id | doaj.art-48956e3aefe448f48e094750b7e1bae0 |
| institution | Directory Open Access Journal |
| issn | 0121-0793 2011-7965 |
| language | Spanish |
| last_indexed | 2024-12-19T05:36:59Z |
| publishDate | 2014-10-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Iatreia |
| spelling | doaj.art-48956e3aefe448f48e094750b7e1bae02022-12-21T20:34:07ZspaUniversidad de AntioquiaIatreia0121-07932011-79652014-10-01274439448Key elements of psoriasis immunogenetics: A reviewDuque Cardona, Leidy Yohana0Sotelo Tascón, Jared 1Velásquez Lopera, Margarita María 2Universidad de AntioquiaUniversidad de AntioquiaHospital Universitario San Vicente FundaciónPsoriasis is one of the most common skin diseases, affecting 2% to 3% of the world population. It occurs at any stage of life. “Early” psoriasis or type I manifests before 40 years, and “late” psoriasis or type II, after 40 years. It has a strong genetic basis and the probability of inheriting the disease when both parents are affected is up to 50%. Different susceptibility regions associated with psoriasis, called PSORS, have been described, PSORS-1 being the most frequent one. It is in chromosome 6 and in this region HLA-Cw6 is located, which is until now the gene more associated with psoriasis. The role of HLA-Cw6 in psoriasis is not fully understood, but it has a relationship with type I psoriasis, guttate psoriasis and presentation of an array of antigens including those derived from Streptococcus pyogenes. Furthermore, some single nucleotide polymorphisms in genes encoding cytokines such as IL-12, IL-23, TNF-α or its receptors are associated with the immunopathogenesis of the disease.http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/17323/17397ImmunogeneticsInterleukin-12Interleukin-17Interleukin-23PsoriasisInmunogenéticaInterleucina-12Interleucina-17Interleucina-23Psoriasis; TNF-αImunogenéticaPsoríaseTNF-α |
| spellingShingle | Duque Cardona, Leidy Yohana Sotelo Tascón, Jared Velásquez Lopera, Margarita María Key elements of psoriasis immunogenetics: A review Iatreia Immunogenetics Interleukin-12 Interleukin-17 Interleukin-23 Psoriasis Inmunogenética Interleucina-12 Interleucina-17 Interleucina-23 Psoriasis; TNF-α Imunogenética Psoríase TNF-α |
| title | Key elements of psoriasis immunogenetics: A review |
| title_full | Key elements of psoriasis immunogenetics: A review |
| title_fullStr | Key elements of psoriasis immunogenetics: A review |
| title_full_unstemmed | Key elements of psoriasis immunogenetics: A review |
| title_short | Key elements of psoriasis immunogenetics: A review |
| title_sort | key elements of psoriasis immunogenetics a review |
| topic | Immunogenetics Interleukin-12 Interleukin-17 Interleukin-23 Psoriasis Inmunogenética Interleucina-12 Interleucina-17 Interleucina-23 Psoriasis; TNF-α Imunogenética Psoríase TNF-α |
| url | http://aprendeenlinea.udea.edu.co/revistas/index.php/iatreia/article/view/17323/17397 |
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