Application of <i>Caenorhabditis elegans</i> in Lipid Metabolism Research
Over the last decade, the development and prevalence of obesity have posed a serious public health risk, which has prompted studies on the regulation of adiposity. With the ease of genetic manipulation, the diversity of the methods for characterizing body fat levels, and the observability of feeding...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/2/1173 |
| _version_ | 1797441543836008448 |
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| author | Lu An Xueqi Fu Jing Chen Junfeng Ma |
| author_facet | Lu An Xueqi Fu Jing Chen Junfeng Ma |
| author_sort | Lu An |
| collection | DOAJ |
| description | Over the last decade, the development and prevalence of obesity have posed a serious public health risk, which has prompted studies on the regulation of adiposity. With the ease of genetic manipulation, the diversity of the methods for characterizing body fat levels, and the observability of feeding behavior, <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) is considered an excellent model for exploring energy homeostasis and the regulation of the cellular fat storage. In addition, the homology with mammals in the genes related to the lipid metabolism allows many aspects of lipid modulation by the regulators of the central nervous system to be conserved in this ideal model organism. In recent years, as the complex network of genes that maintain an energy balance has been gradually expanded and refined, the regulatory mechanisms of lipid storage have become clearer. Furthermore, the development of methods and devices to assess the lipid levels has become a powerful tool for studies in lipid droplet biology and the regulation of the nematode lipid metabolism. Herein, based on the rapid progress of <i>C. elegans</i> lipid metabolism-related studies, this review outlined the lipid metabolic processes, the major signaling pathways of fat storage regulation, and the primary experimental methods to assess the lipid content in nematodes. Therefore, this model system holds great promise for facilitating the understanding, management, and therapies of human obesity and other metabolism-related diseases. |
| first_indexed | 2024-03-09T12:24:41Z |
| format | Article |
| id | doaj.art-489615d2c2194a20abb774dd2eb50700 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:24:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-489615d2c2194a20abb774dd2eb507002023-11-30T22:36:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01242117310.3390/ijms24021173Application of <i>Caenorhabditis elegans</i> in Lipid Metabolism ResearchLu An0Xueqi Fu1Jing Chen2Junfeng Ma3National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, ChinaNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, ChinaNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, ChinaNational Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, ChinaOver the last decade, the development and prevalence of obesity have posed a serious public health risk, which has prompted studies on the regulation of adiposity. With the ease of genetic manipulation, the diversity of the methods for characterizing body fat levels, and the observability of feeding behavior, <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) is considered an excellent model for exploring energy homeostasis and the regulation of the cellular fat storage. In addition, the homology with mammals in the genes related to the lipid metabolism allows many aspects of lipid modulation by the regulators of the central nervous system to be conserved in this ideal model organism. In recent years, as the complex network of genes that maintain an energy balance has been gradually expanded and refined, the regulatory mechanisms of lipid storage have become clearer. Furthermore, the development of methods and devices to assess the lipid levels has become a powerful tool for studies in lipid droplet biology and the regulation of the nematode lipid metabolism. Herein, based on the rapid progress of <i>C. elegans</i> lipid metabolism-related studies, this review outlined the lipid metabolic processes, the major signaling pathways of fat storage regulation, and the primary experimental methods to assess the lipid content in nematodes. Therefore, this model system holds great promise for facilitating the understanding, management, and therapies of human obesity and other metabolism-related diseases.https://www.mdpi.com/1422-0067/24/2/1173<i>Caenorhabditis elegans</i>obesitylipid metabolismfat-regulatory pathwaysfat storage characterization |
| spellingShingle | Lu An Xueqi Fu Jing Chen Junfeng Ma Application of <i>Caenorhabditis elegans</i> in Lipid Metabolism Research International Journal of Molecular Sciences <i>Caenorhabditis elegans</i> obesity lipid metabolism fat-regulatory pathways fat storage characterization |
| title | Application of <i>Caenorhabditis elegans</i> in Lipid Metabolism Research |
| title_full | Application of <i>Caenorhabditis elegans</i> in Lipid Metabolism Research |
| title_fullStr | Application of <i>Caenorhabditis elegans</i> in Lipid Metabolism Research |
| title_full_unstemmed | Application of <i>Caenorhabditis elegans</i> in Lipid Metabolism Research |
| title_short | Application of <i>Caenorhabditis elegans</i> in Lipid Metabolism Research |
| title_sort | application of i caenorhabditis elegans i in lipid metabolism research |
| topic | <i>Caenorhabditis elegans</i> obesity lipid metabolism fat-regulatory pathways fat storage characterization |
| url | https://www.mdpi.com/1422-0067/24/2/1173 |
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