Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral Nigeria
In this study, we explored a fungal strain UIAU-3F identified as <i>Aspergillus fumigatus</i> isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentati...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/1/109 |
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| author | Oluwatofunmilayo A. Diyaolu Gagan Preet Adeshola A. Fagbemi Frederick Annang Guiomar Pérez-Moreno Cristina Bosch-Navarrete Olusoji O. Adebisi Emmanuel T. Oluwabusola Bruce F. Milne Marcel Jaspars Rainer Ebel |
| author_facet | Oluwatofunmilayo A. Diyaolu Gagan Preet Adeshola A. Fagbemi Frederick Annang Guiomar Pérez-Moreno Cristina Bosch-Navarrete Olusoji O. Adebisi Emmanuel T. Oluwabusola Bruce F. Milne Marcel Jaspars Rainer Ebel |
| author_sort | Oluwatofunmilayo A. Diyaolu |
| collection | DOAJ |
| description | In this study, we explored a fungal strain UIAU-3F identified as <i>Aspergillus fumigatus</i> isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (<b>1</b>) and pseurotin D (<b>2</b>). The in vitro antiparasitic assays of <b>1</b> against <i>Trypanosoma cruzi</i> and <i>Plasmodium falciparum</i> showed moderate activity with IC<sub>50</sub> values of 9.6 µM and 2.3 µM, respectively, while <b>2</b> displayed IC<sub>50</sub> values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds. |
| first_indexed | 2024-03-09T13:48:02Z |
| format | Article |
| id | doaj.art-4897d049b8ae4b769ae45ff28be9c68e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T13:48:02Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-4897d049b8ae4b769ae45ff28be9c68e2023-11-30T20:55:50ZengMDPI AGAntibiotics2079-63822023-01-0112110910.3390/antibiotics12010109Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral NigeriaOluwatofunmilayo A. Diyaolu0Gagan Preet1Adeshola A. Fagbemi2Frederick Annang3Guiomar Pérez-Moreno4Cristina Bosch-Navarrete5Olusoji O. Adebisi6Emmanuel T. Oluwabusola7Bruce F. Milne8Marcel Jaspars9Rainer Ebel10Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UKMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UKDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Lead City University, Ibadan 200005, NigeriaFundación MEDINA, Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento 34, Armilla, 18016 Granada, SpainInstitut de Parasitiologia Biomedicina “Lopez-Neyra”, Consejo Superior de Investigaciones Cientificas (CSIC) Avda. Del Conocimiento 17, Armilla, 18016 Granada, SpainInstitut de Parasitiologia Biomedicina “Lopez-Neyra”, Consejo Superior de Investigaciones Cientificas (CSIC) Avda. Del Conocimiento 17, Armilla, 18016 Granada, SpainSchool of Biosciences, Aston University Birmingham, Birmingham B4 7ET, UKMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UKMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UKMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UKMarine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3UE, UKIn this study, we explored a fungal strain UIAU-3F identified as <i>Aspergillus fumigatus</i> isolated from soil samples collected from the River Oyun in Kwara State, Nigeria. In order to explore its chemical diversity, the fungal strain UIAU-3F was cultured in three different fermentation media, which resulted in different chemical profiles, evidenced by LC-ESI-MS-based metabolomics and multivariate analysis. The methanolic extract afforded two known compounds, fumitremorgin C (<b>1</b>) and pseurotin D (<b>2</b>). The in vitro antiparasitic assays of <b>1</b> against <i>Trypanosoma cruzi</i> and <i>Plasmodium falciparum</i> showed moderate activity with IC<sub>50</sub> values of 9.6 µM and 2.3 µM, respectively, while <b>2</b> displayed IC<sub>50</sub> values > 50 µM. Molecular docking analysis was performed on major protein targets to better understand the potential mechanism of the antitrypanosomal and antiplasmodial activities of the two known compounds.https://www.mdpi.com/2079-6382/12/1/109<i>Aspergillus fumigatus</i>OSMACmetabolomicsmolecular dockingantitrypanosomalantiplasmodial |
| spellingShingle | Oluwatofunmilayo A. Diyaolu Gagan Preet Adeshola A. Fagbemi Frederick Annang Guiomar Pérez-Moreno Cristina Bosch-Navarrete Olusoji O. Adebisi Emmanuel T. Oluwabusola Bruce F. Milne Marcel Jaspars Rainer Ebel Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral Nigeria Antibiotics <i>Aspergillus fumigatus</i> OSMAC metabolomics molecular docking antitrypanosomal antiplasmodial |
| title | Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral Nigeria |
| title_full | Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral Nigeria |
| title_fullStr | Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral Nigeria |
| title_full_unstemmed | Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral Nigeria |
| title_short | Antiparasitic Activities of Compounds Isolated from <i>Aspergillus fumigatus</i> Strain Discovered in Northcentral Nigeria |
| title_sort | antiparasitic activities of compounds isolated from i aspergillus fumigatus i strain discovered in northcentral nigeria |
| topic | <i>Aspergillus fumigatus</i> OSMAC metabolomics molecular docking antitrypanosomal antiplasmodial |
| url | https://www.mdpi.com/2079-6382/12/1/109 |
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