Photoactive Herbal Compounds: A Green Approach to Photodynamic Therapy
Photodynamic therapy (PDT) is a minimally invasive, alternative, and promising treatment for various diseases, including cancer, actinic keratosis, Bowen’s disease, macular degeneration, and atherosclerotic plaques. PDT involves three different components, photosensitizers (PS), molecular oxygen, an...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/16/5084 |
| _version_ | 1797431820169510912 |
|---|---|
| author | Cheruthazhakkat Sulaiman Blassan P. George Indira Balachandran Heidi Abrahamse |
| author_facet | Cheruthazhakkat Sulaiman Blassan P. George Indira Balachandran Heidi Abrahamse |
| author_sort | Cheruthazhakkat Sulaiman |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a minimally invasive, alternative, and promising treatment for various diseases, including cancer, actinic keratosis, Bowen’s disease, macular degeneration, and atherosclerotic plaques. PDT involves three different components, photosensitizers (PS), molecular oxygen, and light. The photoactivation of administered PSs using a specific wavelength of light in the presence of molecular oxygen leads to the generation of reactive oxygen species that leads to tumour cell death. Photosensitizing potentials of many commercially available compounds have been reported earlier. However, the possibilities of PDT using herbal medicines, which contain many photosensitizing phytochemicals, are not much explored. Medicinal plants with complex phytochemical compound mixtures have the benefit over single compounds or molecules in the treatment of many diseases with the benefit of low or reduced toxic side effects. This review emphasizes the role of various herbal medicines either alone or in combination to enhance the therapeutic outcome of photodynamic therapy. |
| first_indexed | 2024-03-09T09:51:48Z |
| format | Article |
| id | doaj.art-489b73a33cd44450a914b5aa2b37a3d0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T09:51:48Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-489b73a33cd44450a914b5aa2b37a3d02023-12-02T00:03:57ZengMDPI AGMolecules1420-30492022-08-012716508410.3390/molecules27165084Photoactive Herbal Compounds: A Green Approach to Photodynamic TherapyCheruthazhakkat Sulaiman0Blassan P. George1Indira Balachandran2Heidi Abrahamse3Phytochemistry Division, Centre for Medicinal Plants Research, Arya Vaidya Sala, Kottakkal 676503, IndiaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein 2028, South AfricaPhytochemistry Division, Centre for Medicinal Plants Research, Arya Vaidya Sala, Kottakkal 676503, IndiaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein 2028, South AfricaPhotodynamic therapy (PDT) is a minimally invasive, alternative, and promising treatment for various diseases, including cancer, actinic keratosis, Bowen’s disease, macular degeneration, and atherosclerotic plaques. PDT involves three different components, photosensitizers (PS), molecular oxygen, and light. The photoactivation of administered PSs using a specific wavelength of light in the presence of molecular oxygen leads to the generation of reactive oxygen species that leads to tumour cell death. Photosensitizing potentials of many commercially available compounds have been reported earlier. However, the possibilities of PDT using herbal medicines, which contain many photosensitizing phytochemicals, are not much explored. Medicinal plants with complex phytochemical compound mixtures have the benefit over single compounds or molecules in the treatment of many diseases with the benefit of low or reduced toxic side effects. This review emphasizes the role of various herbal medicines either alone or in combination to enhance the therapeutic outcome of photodynamic therapy.https://www.mdpi.com/1420-3049/27/16/5084photodynamic therapyplantsphytochemicalsphotosensitizersherbal medicinenatural products |
| spellingShingle | Cheruthazhakkat Sulaiman Blassan P. George Indira Balachandran Heidi Abrahamse Photoactive Herbal Compounds: A Green Approach to Photodynamic Therapy Molecules photodynamic therapy plants phytochemicals photosensitizers herbal medicine natural products |
| title | Photoactive Herbal Compounds: A Green Approach to Photodynamic Therapy |
| title_full | Photoactive Herbal Compounds: A Green Approach to Photodynamic Therapy |
| title_fullStr | Photoactive Herbal Compounds: A Green Approach to Photodynamic Therapy |
| title_full_unstemmed | Photoactive Herbal Compounds: A Green Approach to Photodynamic Therapy |
| title_short | Photoactive Herbal Compounds: A Green Approach to Photodynamic Therapy |
| title_sort | photoactive herbal compounds a green approach to photodynamic therapy |
| topic | photodynamic therapy plants phytochemicals photosensitizers herbal medicine natural products |
| url | https://www.mdpi.com/1420-3049/27/16/5084 |
| work_keys_str_mv | AT cheruthazhakkatsulaiman photoactiveherbalcompoundsagreenapproachtophotodynamictherapy AT blassanpgeorge photoactiveherbalcompoundsagreenapproachtophotodynamictherapy AT indirabalachandran photoactiveherbalcompoundsagreenapproachtophotodynamictherapy AT heidiabrahamse photoactiveherbalcompoundsagreenapproachtophotodynamictherapy |