Relationship between low vitamin D levels with Hashimoto thyroiditis
Introduction/Objective. Vitamin D not only plays a role in calcium and phosphorus metabolism, but also has antiproliferative, prodifferentiation, anti-inflammatory and immunomodulatory effects. The aim of this study was to investigate the association between vitamin D deficiency in individuals with...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2023-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300035G.pdf |
| _version_ | 1797748888813174784 |
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| author | Gašić Sanja Smiljić Sonja Milanović Zvezdan Gašić Miloš Ilić Slađana Bogosavljević Ivan Dejanović Mirjana Nestorović Vojkan Matić Tamara |
| author_facet | Gašić Sanja Smiljić Sonja Milanović Zvezdan Gašić Miloš Ilić Slađana Bogosavljević Ivan Dejanović Mirjana Nestorović Vojkan Matić Tamara |
| author_sort | Gašić Sanja |
| collection | DOAJ |
| description | Introduction/Objective. Vitamin D not only plays a role in calcium and phosphorus metabolism, but also has antiproliferative, prodifferentiation, anti-inflammatory and immunomodulatory effects. The aim of this study was to investigate the association between vitamin D deficiency in individuals with autoimmune Hashimoto’s thyroiditis. Methods. A total of 156 patients were enrolled and divided into two groups. First group included 108 patients with 25 (OH) D insufficiency, and second included 48 individuals with normal 25 (OH) D levels. All participants underwent a detailed clinical examination, laboratory tests for thyroid function [T3, fT4, TSH, thyroid antibodies (TPO-Ab, and TG-Ab)], as well as ultrasound scanning (thyroid volume and Doppler characteristics). Results. The patients with vitamin D insufficiency (n = 108 (69.2%)) were predominantly female and had a higher body mass index than the patients with normal vitamin D levels. The group with vitamin D insufficiency had statistically significantly higher TSH levels. The prevalence of positive thyroid antibodies was higher in the vitamin D insufficiency group, while thyroid volume, superior thyroid artery, and inferior thyroid arteries resistance index, as well as the prevalence of positive circular dichroism signals, were significantly higher in the vitamin D insufficiency group. Out of the 156 subjects, 44 were diagnosed with thyroiditis (28.2%). The mean serum level of 25 (OH) D was statistically notably lower in patients with thyroiditis (20.23 ± 8.10 ng/mL) than in the group without thyroiditis (25.44 ± 8.38 ng/mL), p < 0.001. Conclusion. There was an association between vitamin D insufficiency and hypothyroidism in subjects with Hashimoto’s thyroiditis. |
| first_indexed | 2024-03-12T16:12:21Z |
| format | Article |
| id | doaj.art-489bcb50691f4b5a915145f6e257dc9b |
| institution | Directory Open Access Journal |
| issn | 0370-8179 2406-0895 |
| language | English |
| last_indexed | 2024-03-12T16:12:21Z |
| publishDate | 2023-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-489bcb50691f4b5a915145f6e257dc9b2023-08-09T12:42:41ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952023-01-011515-629630110.2298/SARH220608035G0370-81792300035GRelationship between low vitamin D levels with Hashimoto thyroiditisGašić Sanja0Smiljić Sonja1https://orcid.org/0000-0003-4173-9461Milanović Zvezdan2Gašić Miloš3https://orcid.org/0000-0001-8192-0164Ilić Slađana4Bogosavljević Ivan5https://orcid.org/0000-0002-5868-6901Dejanović Mirjana6https://orcid.org/0000-0003-1499-677XNestorović Vojkan7https://orcid.org/0000-0003-0751-8163Matić Tamara8University of Priština - Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, SerbiaUniversity of Priština - Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, SerbiaUniversity of Priština - Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, SerbiaUniversity of Priština - Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, SerbiaMSB, Institute for Health Protection of Workers, Belgrade, SerbiaUniversity of Priština - Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, SerbiaUniversity of Priština - Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, SerbiaUniversity of Priština - Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, SerbiaUniversity of Priština - Kosovska Mitrovica, Faculty of Medicine, Kosovska Mitrovica, SerbiaIntroduction/Objective. Vitamin D not only plays a role in calcium and phosphorus metabolism, but also has antiproliferative, prodifferentiation, anti-inflammatory and immunomodulatory effects. The aim of this study was to investigate the association between vitamin D deficiency in individuals with autoimmune Hashimoto’s thyroiditis. Methods. A total of 156 patients were enrolled and divided into two groups. First group included 108 patients with 25 (OH) D insufficiency, and second included 48 individuals with normal 25 (OH) D levels. All participants underwent a detailed clinical examination, laboratory tests for thyroid function [T3, fT4, TSH, thyroid antibodies (TPO-Ab, and TG-Ab)], as well as ultrasound scanning (thyroid volume and Doppler characteristics). Results. The patients with vitamin D insufficiency (n = 108 (69.2%)) were predominantly female and had a higher body mass index than the patients with normal vitamin D levels. The group with vitamin D insufficiency had statistically significantly higher TSH levels. The prevalence of positive thyroid antibodies was higher in the vitamin D insufficiency group, while thyroid volume, superior thyroid artery, and inferior thyroid arteries resistance index, as well as the prevalence of positive circular dichroism signals, were significantly higher in the vitamin D insufficiency group. Out of the 156 subjects, 44 were diagnosed with thyroiditis (28.2%). The mean serum level of 25 (OH) D was statistically notably lower in patients with thyroiditis (20.23 ± 8.10 ng/mL) than in the group without thyroiditis (25.44 ± 8.38 ng/mL), p < 0.001. Conclusion. There was an association between vitamin D insufficiency and hypothyroidism in subjects with Hashimoto’s thyroiditis.https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300035G.pdfvitamin dinsufficiencyhashimoto's thyroiditis |
| spellingShingle | Gašić Sanja Smiljić Sonja Milanović Zvezdan Gašić Miloš Ilić Slađana Bogosavljević Ivan Dejanović Mirjana Nestorović Vojkan Matić Tamara Relationship between low vitamin D levels with Hashimoto thyroiditis Srpski Arhiv za Celokupno Lekarstvo vitamin d insufficiency hashimoto's thyroiditis |
| title | Relationship between low vitamin D levels with Hashimoto thyroiditis |
| title_full | Relationship between low vitamin D levels with Hashimoto thyroiditis |
| title_fullStr | Relationship between low vitamin D levels with Hashimoto thyroiditis |
| title_full_unstemmed | Relationship between low vitamin D levels with Hashimoto thyroiditis |
| title_short | Relationship between low vitamin D levels with Hashimoto thyroiditis |
| title_sort | relationship between low vitamin d levels with hashimoto thyroiditis |
| topic | vitamin d insufficiency hashimoto's thyroiditis |
| url | https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300035G.pdf |
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