Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)

Fungi are widely distributed in the terrestrial environment, freshwater, and marine habitat. Only approximately 100,000 of these have been classified although there are about 5.1 million characteristic fungi all over the world. These eukaryotic microbes produce specialized metabolites and participat...

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Main Authors: Quan Dai, Fa-Lei Zhang, Tao Feng
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Journal of Fungi
Subjects:
Online Access:https://www.mdpi.com/2309-608X/7/12/1026
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author Quan Dai
Fa-Lei Zhang
Tao Feng
author_facet Quan Dai
Fa-Lei Zhang
Tao Feng
author_sort Quan Dai
collection DOAJ
description Fungi are widely distributed in the terrestrial environment, freshwater, and marine habitat. Only approximately 100,000 of these have been classified although there are about 5.1 million characteristic fungi all over the world. These eukaryotic microbes produce specialized metabolites and participate in a variety of ecological functions, such as quorum detection, chemical defense, allelopathy, and maintenance of symbiosis. Fungi therefore remain an important resource for the screening and discovery of biologically active natural products. Sesquiterpenoids are arguably the richest natural products from plants and micro-organisms. The rearrangement of the 15 high-ductility carbons gave rise to a large number of different skeletons. At the same time, abundant structural variations lead to a diversification of biological activity. This review examines the isolation, structural determination, bioactivities, and synthesis of sesquiterpenoids that were specially produced by fungi over the past five years (2015–2020).
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spelling doaj.art-489c77dd747b42979bc2ad640f5e5d5e2023-11-23T09:04:47ZengMDPI AGJournal of Fungi2309-608X2021-11-01712102610.3390/jof7121026Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)Quan Dai0Fa-Lei Zhang1Tao Feng2School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, ChinaFungi are widely distributed in the terrestrial environment, freshwater, and marine habitat. Only approximately 100,000 of these have been classified although there are about 5.1 million characteristic fungi all over the world. These eukaryotic microbes produce specialized metabolites and participate in a variety of ecological functions, such as quorum detection, chemical defense, allelopathy, and maintenance of symbiosis. Fungi therefore remain an important resource for the screening and discovery of biologically active natural products. Sesquiterpenoids are arguably the richest natural products from plants and micro-organisms. The rearrangement of the 15 high-ductility carbons gave rise to a large number of different skeletons. At the same time, abundant structural variations lead to a diversification of biological activity. This review examines the isolation, structural determination, bioactivities, and synthesis of sesquiterpenoids that were specially produced by fungi over the past five years (2015–2020).https://www.mdpi.com/2309-608X/7/12/1026sesquiterpenoidsfungusstructuresstructural diversitybiological activitysynthesis
spellingShingle Quan Dai
Fa-Lei Zhang
Tao Feng
Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)
Journal of Fungi
sesquiterpenoids
fungus
structures
structural diversity
biological activity
synthesis
title Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)
title_full Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)
title_fullStr Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)
title_full_unstemmed Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)
title_short Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)
title_sort sesquiterpenoids specially produced by fungi structures biological activities chemical and biosynthesis 2015 2020
topic sesquiterpenoids
fungus
structures
structural diversity
biological activity
synthesis
url https://www.mdpi.com/2309-608X/7/12/1026
work_keys_str_mv AT quandai sesquiterpenoidsspeciallyproducedbyfungistructuresbiologicalactivitieschemicalandbiosynthesis20152020
AT faleizhang sesquiterpenoidsspeciallyproducedbyfungistructuresbiologicalactivitieschemicalandbiosynthesis20152020
AT taofeng sesquiterpenoidsspeciallyproducedbyfungistructuresbiologicalactivitieschemicalandbiosynthesis20152020