Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study
Cerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation playing a crucial role in related health complications, including dementia, stroke, and SVD. Studies, including animal experiments, indicate a strong link between inflammation and SVD progression. The Neutrophil-L...
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MDPI AG
2023-07-01
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| Online Access: | https://www.mdpi.com/2076-3425/13/7/1087 |
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| author | Shao-Yuan Chuang Yin-Chen Hsu Kuang-Wei Chou Kuo-Song Chang Chiong-Hee Wong Ya-Hui Hsu Hao-Min Cheng Chien-Wei Chen Pang-Yen Chen |
| author_facet | Shao-Yuan Chuang Yin-Chen Hsu Kuang-Wei Chou Kuo-Song Chang Chiong-Hee Wong Ya-Hui Hsu Hao-Min Cheng Chien-Wei Chen Pang-Yen Chen |
| author_sort | Shao-Yuan Chuang |
| collection | DOAJ |
| description | Cerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation playing a crucial role in related health complications, including dementia, stroke, and SVD. Studies, including animal experiments, indicate a strong link between inflammation and SVD progression. The Neutrophil-Lymphocyte Ratio (NLR) serves as a possible biomarker for ongoing inflammatory risks. A total of 720 adults aged 50 years or older from the community-based I-Lan Longitudinal Aging Study were included in this study. General linear regression and ordinally logistic regression analyses were performed to evaluate the association between NLR and CSVD. We further examined the presence of lacune, microbleed, and white matter hyperintensity (WMH) on brain MRI, which were used to construct a combined CSVD score. The NLR was positively associated with WMH (adjusted r = 0.109, <i>p</i> = 0.003), microbleed (adjusted r = 0.102, <i>p</i> = 0.006), and lacune (adjusted r = 0.100, <i>p</i> = 0.008). After adjustments for smoking, drinking, and physical activity in the ordinal logistic regression analysis, age, gender, brachial Systolic Blood Pressure (SBP), fasting glucose, LDL-cholesterol, and Hs-CRP were compared among subjects with low tertile (T1), medium tertile (T2) and high tertile (T3) NLR. The results showed that T2 vs. T1 had an odds ratio of 1.23 (0.86–1.77); and T3 vs. T1 had an odds ratio of 1.87 (1.29–2.71) of CSVD scores in four groups (zero (reference group), one, two, and three or more). NLR could be used to assess the state of inflammation in cerebral vessels. A significant and positive correlation between NLR and CSVD was verified in this study. However, the practical clinical application of NLR in CSVD patients and prognosis prediction should be validated through more scientific attempts. |
| first_indexed | 2024-03-11T01:14:28Z |
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| last_indexed | 2024-03-11T01:14:28Z |
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| spelling | doaj.art-489d005b45414cb7b9ffea6c3b40475a2023-11-18T18:35:10ZengMDPI AGBrain Sciences2076-34252023-07-01137108710.3390/brainsci13071087Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging StudyShao-Yuan Chuang0Yin-Chen Hsu1Kuang-Wei Chou2Kuo-Song Chang3Chiong-Hee Wong4Ya-Hui Hsu5Hao-Min Cheng6Chien-Wei Chen7Pang-Yen Chen8Institute of Population Health Science, National Health Research Institute, Miaoli 36001, TaiwanDepartment of Nursing, Yuanpei University of Medical Technology, Hsinchu 30015, TaiwanDepartment of Nursing, Yuanpei University of Medical Technology, Hsinchu 30015, TaiwanDepartment of Emergency Medicine, Mackay Memorial Hospital, Taipei 11008, TaiwanDepartment of Emergency Medicine, Mackay Memorial Hospital, Taipei 11008, TaiwanDepartment of Nursing, Yuanpei University of Medical Technology, Hsinchu 30015, TaiwanInstitute of Public Health, National Yang Ming Chiao Tung University School of Medicine, Taipei 30010, TaiwanDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital Chiayi Branch, Chiayi 61363, TaiwanInstitute of Public Health, National Yang Ming Chiao Tung University School of Medicine, Taipei 30010, TaiwanCerebral Small Vessel Disease (CSVD) frequently affects the elderly, with inflammation playing a crucial role in related health complications, including dementia, stroke, and SVD. Studies, including animal experiments, indicate a strong link between inflammation and SVD progression. The Neutrophil-Lymphocyte Ratio (NLR) serves as a possible biomarker for ongoing inflammatory risks. A total of 720 adults aged 50 years or older from the community-based I-Lan Longitudinal Aging Study were included in this study. General linear regression and ordinally logistic regression analyses were performed to evaluate the association between NLR and CSVD. We further examined the presence of lacune, microbleed, and white matter hyperintensity (WMH) on brain MRI, which were used to construct a combined CSVD score. The NLR was positively associated with WMH (adjusted r = 0.109, <i>p</i> = 0.003), microbleed (adjusted r = 0.102, <i>p</i> = 0.006), and lacune (adjusted r = 0.100, <i>p</i> = 0.008). After adjustments for smoking, drinking, and physical activity in the ordinal logistic regression analysis, age, gender, brachial Systolic Blood Pressure (SBP), fasting glucose, LDL-cholesterol, and Hs-CRP were compared among subjects with low tertile (T1), medium tertile (T2) and high tertile (T3) NLR. The results showed that T2 vs. T1 had an odds ratio of 1.23 (0.86–1.77); and T3 vs. T1 had an odds ratio of 1.87 (1.29–2.71) of CSVD scores in four groups (zero (reference group), one, two, and three or more). NLR could be used to assess the state of inflammation in cerebral vessels. A significant and positive correlation between NLR and CSVD was verified in this study. However, the practical clinical application of NLR in CSVD patients and prognosis prediction should be validated through more scientific attempts.https://www.mdpi.com/2076-3425/13/7/1087cerebral small vessel diseaseinflammatory markersneutrophil countneutrophil–lymphocyte ratiowhite matter hyperintensitieslacunar infarcts |
| spellingShingle | Shao-Yuan Chuang Yin-Chen Hsu Kuang-Wei Chou Kuo-Song Chang Chiong-Hee Wong Ya-Hui Hsu Hao-Min Cheng Chien-Wei Chen Pang-Yen Chen Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study Brain Sciences cerebral small vessel disease inflammatory markers neutrophil count neutrophil–lymphocyte ratio white matter hyperintensities lacunar infarcts |
| title | Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study |
| title_full | Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study |
| title_fullStr | Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study |
| title_full_unstemmed | Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study |
| title_short | Neutrophil–Lymphocyte Ratio as a Predictor of Cerebral Small Vessel Disease in a Geriatric Community: The I-Lan Longitudinal Aging Study |
| title_sort | neutrophil lymphocyte ratio as a predictor of cerebral small vessel disease in a geriatric community the i lan longitudinal aging study |
| topic | cerebral small vessel disease inflammatory markers neutrophil count neutrophil–lymphocyte ratio white matter hyperintensities lacunar infarcts |
| url | https://www.mdpi.com/2076-3425/13/7/1087 |
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