A preliminary case series comparison of chest computerized tomography scan and Polymerase Chain Reaction (PCR) for COVID-19 contact tracing in developing countries with limited resources
Background: Imaging and PCR each have a role in detecting and implementing precautionary measures in isolating individuals with a history of close contact, which helps limit the COVID-19 pandemic. Due to developing countries' difficulties, PCR is limited in Iran. This study seeks to determine t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2022-12-01
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| Series: | Novelty in Biomedicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/nbm/article/view/37938 |
| _version_ | 1827966599364083712 |
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| author | Hooman Bahrami-Motlagh Amir Mohammad Papan Zahra Sahraei Babak Salevatipour Maryam Haghighimorad Alireza Karami Mana Zaman Rastin Radfar Minoosh Shabani |
| author_facet | Hooman Bahrami-Motlagh Amir Mohammad Papan Zahra Sahraei Babak Salevatipour Maryam Haghighimorad Alireza Karami Mana Zaman Rastin Radfar Minoosh Shabani |
| author_sort | Hooman Bahrami-Motlagh |
| collection | DOAJ |
| description | Background: Imaging and PCR each have a role in detecting and implementing precautionary measures in
isolating individuals with a history of close contact, which helps limit the COVID-19 pandemic. Due to
developing countries' difficulties, PCR is limited in Iran. This study seeks to determine the feasibility of early
low-dose chest computed tomography (CT) scans substitution with PCR.
Materials and Methods: Asymptomatic participants with a history of close contact with a confirmed case of
COVID-19 were enrolled and followed for one week, receiving 2 PCR tests within one week. Initially, a chest
CT scan was performed. The second CT scan was performed within one week on two participants. Participants
with an initially negative CT scan and participants with a first CT scan compatible with COVID-19 who became
symptomatic.
Results: All Participants had an RT-PCR and at least one CT scan. Positive RT-PCR results were reported in
6 and 9 participants initially and within one week, respectively. Chest CT scans favoring COVID-19 infection
were initially reported in 4 and 6 participants within one week, respectively. Seventeen participants showed
neither symptoms nor positive RT-PCR or chested CT scans favoring COVID-19. Thirteen participants either
had positive RT-PCR, a COVID-19 chest CT scan or became symptomatic.
Conclusion: Rapid detection of COVID-19 and subsequent quarantining is crucial in the global fight against
this pandemic. Our results showed lower sensitivity for chest CT scans compared to COVID-19 PCR,
suggesting that chest CT scans are unsuitable for COVID-19 PCR tests. |
| first_indexed | 2024-04-09T17:51:19Z |
| format | Article |
| id | doaj.art-48a09f65c9af4dd3ae8440dcb3e4f1c9 |
| institution | Directory Open Access Journal |
| issn | 2345-3907 |
| language | English |
| last_indexed | 2024-04-09T17:51:19Z |
| publishDate | 2022-12-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Novelty in Biomedicine |
| spelling | doaj.art-48a09f65c9af4dd3ae8440dcb3e4f1c92023-04-15T17:57:39ZengShahid Beheshti University of Medical SciencesNovelty in Biomedicine2345-39072022-12-0110420721210.22037/nbm.v10i4.3793837938A preliminary case series comparison of chest computerized tomography scan and Polymerase Chain Reaction (PCR) for COVID-19 contact tracing in developing countries with limited resourcesHooman Bahrami-Motlaghhttps://orcid.org/0000-0002-0593-8511Amir Mohammad Papanhttps://orcid.org/0000-0002-6121-7137Zahra Sahraeihttps://orcid.org/0000-0002-0178-8624Babak Salevatipourhttps://orcid.org/0000-0002-0304-2914Maryam Haghighimoradhttps://orcid.org/0000-0003-0086-9446Alireza KaramiMana ZamanRastin RadfarMinoosh Shabanihttps://orcid.org/0000-0002-4064-8325Background: Imaging and PCR each have a role in detecting and implementing precautionary measures in isolating individuals with a history of close contact, which helps limit the COVID-19 pandemic. Due to developing countries' difficulties, PCR is limited in Iran. This study seeks to determine the feasibility of early low-dose chest computed tomography (CT) scans substitution with PCR. Materials and Methods: Asymptomatic participants with a history of close contact with a confirmed case of COVID-19 were enrolled and followed for one week, receiving 2 PCR tests within one week. Initially, a chest CT scan was performed. The second CT scan was performed within one week on two participants. Participants with an initially negative CT scan and participants with a first CT scan compatible with COVID-19 who became symptomatic. Results: All Participants had an RT-PCR and at least one CT scan. Positive RT-PCR results were reported in 6 and 9 participants initially and within one week, respectively. Chest CT scans favoring COVID-19 infection were initially reported in 4 and 6 participants within one week, respectively. Seventeen participants showed neither symptoms nor positive RT-PCR or chested CT scans favoring COVID-19. Thirteen participants either had positive RT-PCR, a COVID-19 chest CT scan or became symptomatic. Conclusion: Rapid detection of COVID-19 and subsequent quarantining is crucial in the global fight against this pandemic. Our results showed lower sensitivity for chest CT scans compared to COVID-19 PCR, suggesting that chest CT scans are unsuitable for COVID-19 PCR tests.https://journals.sbmu.ac.ir/nbm/article/view/37938covid-19, ct scan, polymerase chain reaction, contact tracing |
| spellingShingle | Hooman Bahrami-Motlagh Amir Mohammad Papan Zahra Sahraei Babak Salevatipour Maryam Haghighimorad Alireza Karami Mana Zaman Rastin Radfar Minoosh Shabani A preliminary case series comparison of chest computerized tomography scan and Polymerase Chain Reaction (PCR) for COVID-19 contact tracing in developing countries with limited resources Novelty in Biomedicine covid-19, ct scan, polymerase chain reaction, contact tracing |
| title | A preliminary case series comparison of chest computerized tomography scan and Polymerase Chain Reaction (PCR) for COVID-19 contact tracing in developing countries with limited resources |
| title_full | A preliminary case series comparison of chest computerized tomography scan and Polymerase Chain Reaction (PCR) for COVID-19 contact tracing in developing countries with limited resources |
| title_fullStr | A preliminary case series comparison of chest computerized tomography scan and Polymerase Chain Reaction (PCR) for COVID-19 contact tracing in developing countries with limited resources |
| title_full_unstemmed | A preliminary case series comparison of chest computerized tomography scan and Polymerase Chain Reaction (PCR) for COVID-19 contact tracing in developing countries with limited resources |
| title_short | A preliminary case series comparison of chest computerized tomography scan and Polymerase Chain Reaction (PCR) for COVID-19 contact tracing in developing countries with limited resources |
| title_sort | preliminary case series comparison of chest computerized tomography scan and polymerase chain reaction pcr for covid 19 contact tracing in developing countries with limited resources |
| topic | covid-19, ct scan, polymerase chain reaction, contact tracing |
| url | https://journals.sbmu.ac.ir/nbm/article/view/37938 |
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