Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based Study
To date, it remains uncertain whether benzodiazepine receptor agonists (BZRAs) are aggravating factors even though these drugs can elevate the levels of biomarkers associated with the development of psoriasis. Therefore, this study aimed to investigate the association of BZRA use with changes in pso...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.596375/full |
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| author | Ke-Ting Pan Ke-Ting Pan I-Hsun Li I-Hsun Li I-Hsun Li Hui-Han Kao Hui-Han Kao Yi-Hsien Chen Pei-Xun Zhong Pei-Xun Zhong Li-Ting Kao Li-Ting Kao Li-Ting Kao Li-Ting Kao |
| author_facet | Ke-Ting Pan Ke-Ting Pan I-Hsun Li I-Hsun Li I-Hsun Li Hui-Han Kao Hui-Han Kao Yi-Hsien Chen Pei-Xun Zhong Pei-Xun Zhong Li-Ting Kao Li-Ting Kao Li-Ting Kao Li-Ting Kao |
| author_sort | Ke-Ting Pan |
| collection | DOAJ |
| description | To date, it remains uncertain whether benzodiazepine receptor agonists (BZRAs) are aggravating factors even though these drugs can elevate the levels of biomarkers associated with the development of psoriasis. Therefore, this study aimed to investigate the association of BZRA use with changes in psoriasis severity. All data were sourced from the National Health Insurance system in Taiwan. We conducted a population-based retrospective cross-sectional study of 15,727 psoriasis patients who received BZRAs (BZRA users), and 18,856 psoriasis patients who did not receive BZRAs (nonusers). At least a 1-year washout period without any BZRA prescriptions was required. The main outcome was the change in psoriasis severity between before and after BZRA exposure. This study detected the exacerbation of psoriasis severity in mild psoriasis population by using a logistic model. Then, this study carried another logistic model among those patients who had severe psoriasis to calculate the odds ratios (ORs) for the improvement of the psoriasis severity. Among patients with mild psoriasis, BZRA users had a significantly higher probability of psoriasis severity exacerbation (IPTW-adjusted OR = 1.46). Mild psoriasis patients who received high and low doses of BZRAs had 1.70- and 1.39-fold higher probabilities of psoriasis severity exacerbation, respectively, than the non-users. Furthermore, in the severe psoriasis population, more low-dose BZRA users improved psoriasis severity than non-users. In conclusion, this study provided clinical evidence of the effects of BZRA use on patients with psoriasis severity. Among patients with mild psoriasis, high-dose BZRA users may be associated with the changes in psoriasis severity. However, low-dose BZRA exposure only slightly exacerbated disease severity among patients with mild psoriasis. Accordingly, clinicians should evaluate the risks and benefits of the BZRA usage. |
| first_indexed | 2024-12-19T21:55:31Z |
| format | Article |
| id | doaj.art-48a3275d478042388b8cdac0c4117d87 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-19T21:55:31Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-48a3275d478042388b8cdac0c4117d872022-12-21T20:04:17ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-07-011210.3389/fphar.2021.596375596375Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based StudyKe-Ting Pan0Ke-Ting Pan1I-Hsun Li2I-Hsun Li3I-Hsun Li4Hui-Han Kao5Hui-Han Kao6Yi-Hsien Chen7Pei-Xun Zhong8Pei-Xun Zhong9Li-Ting Kao10Li-Ting Kao11Li-Ting Kao12Li-Ting Kao13Institute of Environmental Design and Engineering, Bartlett School, UCL, London, United KingdomGraduate Institute of Aerospace and Undersea Medicine, National Defense Medical Centre, Taipei, TaiwanDepartment of Pharmacy Practice, Tri-Service General Hospital, Taipei, TaiwanSchool of Pharmacy, National Defense Medical Center, Taipei, TaiwanDepartment of Pharmacology, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, TaiwanScience and Technology Policy Research and Information Center, National Applied Research Laboratories, Taipei, TaiwanDepartment of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Pharmacy Practice, Tri-Service General Hospital, Taipei, TaiwanSchool of Pharmacy, National Defense Medical Center, Taipei, TaiwanDepartment of Pharmacy Practice, Tri-Service General Hospital, Taipei, TaiwanSchool of Pharmacy, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, TaiwanSchool of Public Health, National Defense Medical Center, Taipei, TaiwanTo date, it remains uncertain whether benzodiazepine receptor agonists (BZRAs) are aggravating factors even though these drugs can elevate the levels of biomarkers associated with the development of psoriasis. Therefore, this study aimed to investigate the association of BZRA use with changes in psoriasis severity. All data were sourced from the National Health Insurance system in Taiwan. We conducted a population-based retrospective cross-sectional study of 15,727 psoriasis patients who received BZRAs (BZRA users), and 18,856 psoriasis patients who did not receive BZRAs (nonusers). At least a 1-year washout period without any BZRA prescriptions was required. The main outcome was the change in psoriasis severity between before and after BZRA exposure. This study detected the exacerbation of psoriasis severity in mild psoriasis population by using a logistic model. Then, this study carried another logistic model among those patients who had severe psoriasis to calculate the odds ratios (ORs) for the improvement of the psoriasis severity. Among patients with mild psoriasis, BZRA users had a significantly higher probability of psoriasis severity exacerbation (IPTW-adjusted OR = 1.46). Mild psoriasis patients who received high and low doses of BZRAs had 1.70- and 1.39-fold higher probabilities of psoriasis severity exacerbation, respectively, than the non-users. Furthermore, in the severe psoriasis population, more low-dose BZRA users improved psoriasis severity than non-users. In conclusion, this study provided clinical evidence of the effects of BZRA use on patients with psoriasis severity. Among patients with mild psoriasis, high-dose BZRA users may be associated with the changes in psoriasis severity. However, low-dose BZRA exposure only slightly exacerbated disease severity among patients with mild psoriasis. Accordingly, clinicians should evaluate the risks and benefits of the BZRA usage.https://www.frontiersin.org/articles/10.3389/fphar.2021.596375/fullbenzodiazepine receptor agonistsbenzodiazepinepsoriasisseveritysafety |
| spellingShingle | Ke-Ting Pan Ke-Ting Pan I-Hsun Li I-Hsun Li I-Hsun Li Hui-Han Kao Hui-Han Kao Yi-Hsien Chen Pei-Xun Zhong Pei-Xun Zhong Li-Ting Kao Li-Ting Kao Li-Ting Kao Li-Ting Kao Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based Study Frontiers in Pharmacology benzodiazepine receptor agonists benzodiazepine psoriasis severity safety |
| title | Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based Study |
| title_full | Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based Study |
| title_fullStr | Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based Study |
| title_full_unstemmed | Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based Study |
| title_short | Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based Study |
| title_sort | association of benzodiazepine receptor agonist use with changes in psoriasis severity in adult population a population based study |
| topic | benzodiazepine receptor agonists benzodiazepine psoriasis severity safety |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.596375/full |
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