Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect
Lactate is a byproduct of anaerobic glycolysis, and hyperlactatemia is commonly seen in critically ill patients. We report a case of an elderly male presenting with undifferentiated constitutional symptoms, anemia, thrombocytopenia, severe lactic acidosis, refractory hypoglycemia, and a newly detect...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-07-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/517658 |
| _version_ | 1818357299956154368 |
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| author | Zainab Al Maqrashi Mary Sedarous Avinash Pandey Catherine Ross Ahraaz Wyne |
| author_facet | Zainab Al Maqrashi Mary Sedarous Avinash Pandey Catherine Ross Ahraaz Wyne |
| author_sort | Zainab Al Maqrashi |
| collection | DOAJ |
| description | Lactate is a byproduct of anaerobic glycolysis, and hyperlactatemia is commonly seen in critically ill patients. We report a case of an elderly male presenting with undifferentiated constitutional symptoms, anemia, thrombocytopenia, severe lactic acidosis, refractory hypoglycemia, and a newly detected abdominal mass. A dedicated workup ruled out infectious etiologies and revealed metastatic non-Hodgkin’s lymphoma. This study explores etiologies of type B lactic acidosis in oncology patients, with a focus on Warburg’s effect, and its potential for prognostication. |
| first_indexed | 2024-12-13T20:10:54Z |
| format | Article |
| id | doaj.art-48a3ce55ae8e4494a6506a935cddc719 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-13T20:10:54Z |
| publishDate | 2021-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-48a3ce55ae8e4494a6506a935cddc7192022-12-21T23:32:55ZengKarger PublishersCase Reports in Oncology1662-65752021-07-011421159116710.1159/000517658517658Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg EffectZainab Al Maqrashi0Mary Sedarous1Avinash Pandey2Catherine Ross3Ahraaz Wyne4Department of General Internal Medicine, McMaster University, Hamilton, ON, CanadaDepartment of General Internal Medicine, McMaster University, Hamilton, ON, CanadaMcMaster University Medical School, Candidate 2021, McMaster University, Hamilton, ON, CanadaDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, CanadaDepartment of General Internal Medicine, McMaster University, Hamilton, ON, CanadaLactate is a byproduct of anaerobic glycolysis, and hyperlactatemia is commonly seen in critically ill patients. We report a case of an elderly male presenting with undifferentiated constitutional symptoms, anemia, thrombocytopenia, severe lactic acidosis, refractory hypoglycemia, and a newly detected abdominal mass. A dedicated workup ruled out infectious etiologies and revealed metastatic non-Hodgkin’s lymphoma. This study explores etiologies of type B lactic acidosis in oncology patients, with a focus on Warburg’s effect, and its potential for prognostication.https://www.karger.com/Article/FullText/517658hyperlactatemiawarburg effectmetabolic acidosisoncological complicationsnon-hodgkin’s lymphoma |
| spellingShingle | Zainab Al Maqrashi Mary Sedarous Avinash Pandey Catherine Ross Ahraaz Wyne Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect Case Reports in Oncology hyperlactatemia warburg effect metabolic acidosis oncological complications non-hodgkin’s lymphoma |
| title | Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect |
| title_full | Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect |
| title_fullStr | Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect |
| title_full_unstemmed | Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect |
| title_short | Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect |
| title_sort | refractory hyperlactatemia and hypoglycemia in an adult with non hodgkin s lymphoma a case report and review of the warburg effect |
| topic | hyperlactatemia warburg effect metabolic acidosis oncological complications non-hodgkin’s lymphoma |
| url | https://www.karger.com/Article/FullText/517658 |
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