microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.

microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.

Increasing evidence suggests that microRNAs are intimately involved in the pathophysiology of heart failure. MicroRNA-22 (miR-22) is a muscle-enriched miRNA required for optimum cardiac gene transcription and adaptation to hemodynamic stress by pressure overload in mice. Recent evidence also suggest...

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Bibliographic Details
Main Authors: Priyatansh Gurha, Tiannan Wang, Ashley H Larimore, Yassine Sassi, Cei Abreu-Goodger, Maricela O Ramirez, Anilkumar K Reddy, Stefan Engelhardt, George E Taffet, Xander H T Wehrens, Mark L Entman, Antony Rodriguez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3785418?pdf=render

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