Molecular mechanisms of tigecycline-resistance among Enterobacterales
The global emergence of antimicrobial resistance to multiple antibiotics has recently become a significant concern. Gram-negative bacteria, known for their ability to acquire mobile genetic elements such as plasmids, represent one of the most hazardous microorganisms. This phenomenon poses a serious...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1289396/full |
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| author | Lukasz Korczak Piotr Majewski Dominika Iwaniuk Pawel Sacha Mariola Matulewicz Piotr Wieczorek Paulina Majewska Anna Wieczorek Piotr Radziwon Elzbieta Tryniszewska |
| author_facet | Lukasz Korczak Piotr Majewski Dominika Iwaniuk Pawel Sacha Mariola Matulewicz Piotr Wieczorek Paulina Majewska Anna Wieczorek Piotr Radziwon Elzbieta Tryniszewska |
| author_sort | Lukasz Korczak |
| collection | DOAJ |
| description | The global emergence of antimicrobial resistance to multiple antibiotics has recently become a significant concern. Gram-negative bacteria, known for their ability to acquire mobile genetic elements such as plasmids, represent one of the most hazardous microorganisms. This phenomenon poses a serious threat to public health. Notably, the significance of tigecycline, a member of the antibiotic group glycylcyclines and derivative of tetracyclines has increased. Tigecycline is one of the last-resort antimicrobial drugs used to treat complicated infections caused by multidrug-resistant (MDR) bacteria, extensively drug-resistant (XDR) bacteria or even pan-drug-resistant (PDR) bacteria. The primary mechanisms of tigecycline resistance include efflux pumps’ overexpression, tet genes and outer membrane porins. Efflux pumps are crucial in conferring multi-drug resistance by expelling antibiotics (such as tigecycline by direct expelling) and decreasing their concentration to sub-toxic levels. This review discusses the problem of tigecycline resistance, and provides important information for understanding the existing molecular mechanisms of tigecycline resistance in Enterobacterales. The emergence and spread of pathogens resistant to last-resort therapeutic options stands as a major global healthcare concern, especially when microorganisms are already resistant to carbapenems and/or colistin. |
| first_indexed | 2024-04-24T11:55:22Z |
| format | Article |
| id | doaj.art-48a423995d434add80aa94d939c57231 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-24T11:55:22Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-48a423995d434add80aa94d939c572312024-04-09T04:48:41ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-04-011410.3389/fcimb.2024.12893961289396Molecular mechanisms of tigecycline-resistance among EnterobacteralesLukasz Korczak0Piotr Majewski1Dominika Iwaniuk2Pawel Sacha3Mariola Matulewicz4Piotr Wieczorek5Paulina Majewska6Anna Wieczorek7Piotr Radziwon8Elzbieta Tryniszewska9Department of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, PolandDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, PolandDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, PolandDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, PolandRegional Centre for Transfusion Medicine, Bialystok, PolandDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, PolandRegional Centre for Transfusion Medicine, Bialystok, PolandDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, PolandRegional Centre for Transfusion Medicine, Bialystok, PolandDepartment of Microbiological Diagnostics and Infectious Immunology, Medical University of Bialystok, Bialystok, PolandThe global emergence of antimicrobial resistance to multiple antibiotics has recently become a significant concern. Gram-negative bacteria, known for their ability to acquire mobile genetic elements such as plasmids, represent one of the most hazardous microorganisms. This phenomenon poses a serious threat to public health. Notably, the significance of tigecycline, a member of the antibiotic group glycylcyclines and derivative of tetracyclines has increased. Tigecycline is one of the last-resort antimicrobial drugs used to treat complicated infections caused by multidrug-resistant (MDR) bacteria, extensively drug-resistant (XDR) bacteria or even pan-drug-resistant (PDR) bacteria. The primary mechanisms of tigecycline resistance include efflux pumps’ overexpression, tet genes and outer membrane porins. Efflux pumps are crucial in conferring multi-drug resistance by expelling antibiotics (such as tigecycline by direct expelling) and decreasing their concentration to sub-toxic levels. This review discusses the problem of tigecycline resistance, and provides important information for understanding the existing molecular mechanisms of tigecycline resistance in Enterobacterales. The emergence and spread of pathogens resistant to last-resort therapeutic options stands as a major global healthcare concern, especially when microorganisms are already resistant to carbapenems and/or colistin.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1289396/fulltigecyclineglycylcyclinesefflux pumpsmultidrug resistance (MDR)Enterobacterales |
| spellingShingle | Lukasz Korczak Piotr Majewski Dominika Iwaniuk Pawel Sacha Mariola Matulewicz Piotr Wieczorek Paulina Majewska Anna Wieczorek Piotr Radziwon Elzbieta Tryniszewska Molecular mechanisms of tigecycline-resistance among Enterobacterales Frontiers in Cellular and Infection Microbiology tigecycline glycylcyclines efflux pumps multidrug resistance (MDR) Enterobacterales |
| title | Molecular mechanisms of tigecycline-resistance among Enterobacterales |
| title_full | Molecular mechanisms of tigecycline-resistance among Enterobacterales |
| title_fullStr | Molecular mechanisms of tigecycline-resistance among Enterobacterales |
| title_full_unstemmed | Molecular mechanisms of tigecycline-resistance among Enterobacterales |
| title_short | Molecular mechanisms of tigecycline-resistance among Enterobacterales |
| title_sort | molecular mechanisms of tigecycline resistance among enterobacterales |
| topic | tigecycline glycylcyclines efflux pumps multidrug resistance (MDR) Enterobacterales |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1289396/full |
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