Association of <i>MARC1</i>, <i>ADCY5,</i> and <i>BCO1</i> Variants with the Lipid Profile, Suggests an Additive Effect for Hypertriglyceridemia in Mexican Adult Men
Epidemiological studies have reported that the Mexican population is highly susceptible to dyslipidemia. The <i>MARC1, ADCY5</i>, and <i>BCO1</i> genes have recently been involved in lipidic abnormalities. This study aimed to analyze the association of single nucleotide polym...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/19/11815 |
| Summary: | Epidemiological studies have reported that the Mexican population is highly susceptible to dyslipidemia. The <i>MARC1, ADCY5</i>, and <i>BCO1</i> genes have recently been involved in lipidic abnormalities. This study aimed to analyze the association of single nucleotide polymorphisms (SNPs) rs2642438, rs56371916, and rs6564851 on <i>MARC1, ADCY5,</i> and <i>BCO1</i> genes, respectively, with the lipid profile in a cohort of Mexican adults. We included 1900 Mexican adults from the Health Workers Cohort Study. Demographic and clinical data were collected through a structured questionnaire and standardized procedures. Genotyping was performed using a predesigned TaqMan assay. A genetic risk score (GRS) was created on the basis of the three genetic variants. Associations analysis was estimated using linear and logistic regression. Our results showed that rs2642438-A and rs6564851-A alleles had a risk association for hypertriglyceridemia (OR = 1.57, <i>p</i> = 0.013; and OR = 1.33, <i>p</i> = 0.031, respectively), and rs56371916-C allele a trend for low HDL-c (OR = 1.27, <i>p</i> = 0.060) only in men. The GRS revealed a significant association for hypertriglyceridemia (OR = 2.23, <i>p</i> = 0.022). These findings provide evidence of an aggregate effect of the <i>MARC1, ADCY5,</i> and <i>BCO1</i> variants on the risk of hypertriglyceridemia in Mexican men. This knowledge could represent a tool for identifying at-risk males who might benefit from early interventions and avoid secondary metabolic traits. |
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| ISSN: | 1661-6596 1422-0067 |