Secondary Cancer Risk after Radiotherapy of Seminoma Stage One
Introduction: In radiation treatment of stage one seminoma (SOS) induced secondary cancer in organs at risk (OARs), is late toxicity of major concern. This study aimed to compare the secondary cancer risk in radiotherapy of SOS in two-dimensional conventional (2D) radiation therapy and three-dimensi...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-05-01
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| Series: | Iranian Journal of Medical Physics |
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| Online Access: | https://ijmp.mums.ac.ir/article_19092_6112e58fed148d2e4b23875e3d098ab3.pdf |
| _version_ | 1797848966039076864 |
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| author | Hamid Ghaznavi Hamid Emami Farzaneh Aallaveisi Parvaneh Shokrani |
| author_facet | Hamid Ghaznavi Hamid Emami Farzaneh Aallaveisi Parvaneh Shokrani |
| author_sort | Hamid Ghaznavi |
| collection | DOAJ |
| description | Introduction: In radiation treatment of stage one seminoma (SOS) induced secondary cancer in organs at risk (OARs), is late toxicity of major concern. This study aimed to compare the secondary cancer risk in radiotherapy of SOS in two-dimensional conventional (2D) radiation therapy and three-dimensional conformal radiation therapy (3DCRT).Material and Methods: CT scan images of 10 patients with SOS were used to design 2D conventional and 3D conformal treatment plans using 25 Gy in 20 sessions. The life attributable risk (LAR) of the liver, stomach, and colon were calculated using the organ equivalent dose (OED) model for organs in the radiation field and the Biologic Effects of Ionizing Radiation VII (BEIR VII) model for organs out of the field.Results: LAR of OARs in radiation fields such as the liver and stomach were obtained 40% higher in the 2D treatment than in the 3D treatment, while as for the colon, it was 17% lower in the 2D treatment than in the 3D treatment. The LAR values of kidneys located outside the radiation field in the 2D treatment were calculated at 0.04%.Conclusion: Increasing the prescribed dose (25 vs. 20) as well as the number of treatment sessions (20 vs. 10) resulted in increase in the LAR of the liver, stomach, and colon. Therefore, estimating the cancer risk of critical organs exposed to radiation through examining the effects of dose fractionation and prescribed doses can be used in optimizing of the treatment plan for seminoma, selecting a better treatment method by oncologists, and patient follow-up. |
| first_indexed | 2024-04-09T18:36:09Z |
| format | Article |
| id | doaj.art-48aa111245364603805ec4f5619270a5 |
| institution | Directory Open Access Journal |
| issn | 2345-3672 |
| language | English |
| last_indexed | 2024-04-09T18:36:09Z |
| publishDate | 2022-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Physics |
| spelling | doaj.art-48aa111245364603805ec4f5619270a52023-04-11T09:41:58ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2345-36722022-05-0119317518010.22038/ijmp.2021.57903.197119092Secondary Cancer Risk after Radiotherapy of Seminoma Stage OneHamid Ghaznavi0Hamid Emami1Farzaneh Aallaveisi2Parvaneh Shokrani3Department of Radiology, Faculty of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Radiation Oncology, School of Medicine, Isfahan University of Medical Sciences. Isfahan, Iran,Department of Medical Physics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranIntroduction: In radiation treatment of stage one seminoma (SOS) induced secondary cancer in organs at risk (OARs), is late toxicity of major concern. This study aimed to compare the secondary cancer risk in radiotherapy of SOS in two-dimensional conventional (2D) radiation therapy and three-dimensional conformal radiation therapy (3DCRT).Material and Methods: CT scan images of 10 patients with SOS were used to design 2D conventional and 3D conformal treatment plans using 25 Gy in 20 sessions. The life attributable risk (LAR) of the liver, stomach, and colon were calculated using the organ equivalent dose (OED) model for organs in the radiation field and the Biologic Effects of Ionizing Radiation VII (BEIR VII) model for organs out of the field.Results: LAR of OARs in radiation fields such as the liver and stomach were obtained 40% higher in the 2D treatment than in the 3D treatment, while as for the colon, it was 17% lower in the 2D treatment than in the 3D treatment. The LAR values of kidneys located outside the radiation field in the 2D treatment were calculated at 0.04%.Conclusion: Increasing the prescribed dose (25 vs. 20) as well as the number of treatment sessions (20 vs. 10) resulted in increase in the LAR of the liver, stomach, and colon. Therefore, estimating the cancer risk of critical organs exposed to radiation through examining the effects of dose fractionation and prescribed doses can be used in optimizing of the treatment plan for seminoma, selecting a better treatment method by oncologists, and patient follow-up.https://ijmp.mums.ac.ir/article_19092_6112e58fed148d2e4b23875e3d098ab3.pdfseminomaradiotherapysecondary cancer risk |
| spellingShingle | Hamid Ghaznavi Hamid Emami Farzaneh Aallaveisi Parvaneh Shokrani Secondary Cancer Risk after Radiotherapy of Seminoma Stage One Iranian Journal of Medical Physics seminoma radiotherapy secondary cancer risk |
| title | Secondary Cancer Risk after Radiotherapy of Seminoma Stage One |
| title_full | Secondary Cancer Risk after Radiotherapy of Seminoma Stage One |
| title_fullStr | Secondary Cancer Risk after Radiotherapy of Seminoma Stage One |
| title_full_unstemmed | Secondary Cancer Risk after Radiotherapy of Seminoma Stage One |
| title_short | Secondary Cancer Risk after Radiotherapy of Seminoma Stage One |
| title_sort | secondary cancer risk after radiotherapy of seminoma stage one |
| topic | seminoma radiotherapy secondary cancer risk |
| url | https://ijmp.mums.ac.ir/article_19092_6112e58fed148d2e4b23875e3d098ab3.pdf |
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