Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.

Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.

Notch1 (N1) signaling induced by intrathymic Delta-like (DL) ligands is required for T cell lineage commitment as well as self-renewal during "β-selection" of TCRβ⁺CD4⁻CD8⁻ double negative 3 (DN3) T cell progenitors. However, over-expression of the N1 intracellular domain (ICN1) renders N1...

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Bibliographic Details
Main Authors: Sara Suliman, Joanne Tan, Keli Xu, Philaretos C Kousis, Paul E Kowalski, Greg Chang, Sean E Egan, Cynthia Guidos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3172312?pdf=render

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