Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partum
Abstract The human vaginal and fecal microbiota change during pregnancy. Because of the proximity of these perineal sites and the evolutionarily conserved maternal-to-neonatal transmission of the microbiota, we hypothesized that the microbiota of these two sites (rectal and vaginal) converge during...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-06-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-023-00404-5 |
| _version_ | 1797801567739445248 |
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| author | Hakdong Shin Keith A. Martinez Nora Henderson Melanie Jay William Schweizer Debby Bogaert Gwoncheol Park Nicholas A. Bokulich Martin J. Blaser Maria Gloria Dominguez-Bello |
| author_facet | Hakdong Shin Keith A. Martinez Nora Henderson Melanie Jay William Schweizer Debby Bogaert Gwoncheol Park Nicholas A. Bokulich Martin J. Blaser Maria Gloria Dominguez-Bello |
| author_sort | Hakdong Shin |
| collection | DOAJ |
| description | Abstract The human vaginal and fecal microbiota change during pregnancy. Because of the proximity of these perineal sites and the evolutionarily conserved maternal-to-neonatal transmission of the microbiota, we hypothesized that the microbiota of these two sites (rectal and vaginal) converge during the last gestational trimester as part of the preparation for parturition. To test this hypothesis, we analyzed 16S rRNA sequences from vaginal introitus and rectal samples in 41 women at gestational ages 6 and 8 months, and at 2 months post-partum. The results show that the human vaginal and rectal bacterial microbiota converged during the last gestational trimester and into the 2nd month after birth, with a significant decrease in Lactobacillus species in both sites, as alpha diversity progressively increased in the vagina and decreased in the rectum. The microbiota convergence of the maternal vaginal-anal sites perinatally might hold significance for the inter-generational transmission of the maternal microbiota. |
| first_indexed | 2024-03-13T04:52:16Z |
| format | Article |
| id | doaj.art-48ae843031d54aaeab293d5beb9de5d7 |
| institution | Directory Open Access Journal |
| issn | 2055-5008 |
| language | English |
| last_indexed | 2024-03-13T04:52:16Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj.art-48ae843031d54aaeab293d5beb9de5d72023-06-18T11:08:10ZengNature Portfolionpj Biofilms and Microbiomes2055-50082023-06-01911610.1038/s41522-023-00404-5Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partumHakdong Shin0Keith A. Martinez1Nora Henderson2Melanie Jay3William Schweizer4Debby Bogaert5Gwoncheol Park6Nicholas A. Bokulich7Martin J. Blaser8Maria Gloria Dominguez-Bello9Department of Food Science & Biotechnology, and Carbohydrate Bioproduct Research Center, College of Life Science, Sejong UniversityDepartment of Medicine, New York University Langone Medical CenterDepartment of Medicine, New York University Langone Medical CenterDepartment of Medicine, New York University Langone Medical CenterDepartment of Obstetrics and Gynecology, New York University Langone Medical CenterMRC Centre for Inflammation Research, University of EdinburghDepartment of Food Science & Biotechnology, and Carbohydrate Bioproduct Research Center, College of Life Science, Sejong UniversityLaboratory of Food Systems Biotechnology, Institute of Food, Nutrition and Health, ETH ZürichCenter for Advanced Biotechnology and Medicine, Rutgers UniversityDepartment of Biochemistry and Microbiology, Rutgers UniversityAbstract The human vaginal and fecal microbiota change during pregnancy. Because of the proximity of these perineal sites and the evolutionarily conserved maternal-to-neonatal transmission of the microbiota, we hypothesized that the microbiota of these two sites (rectal and vaginal) converge during the last gestational trimester as part of the preparation for parturition. To test this hypothesis, we analyzed 16S rRNA sequences from vaginal introitus and rectal samples in 41 women at gestational ages 6 and 8 months, and at 2 months post-partum. The results show that the human vaginal and rectal bacterial microbiota converged during the last gestational trimester and into the 2nd month after birth, with a significant decrease in Lactobacillus species in both sites, as alpha diversity progressively increased in the vagina and decreased in the rectum. The microbiota convergence of the maternal vaginal-anal sites perinatally might hold significance for the inter-generational transmission of the maternal microbiota.https://doi.org/10.1038/s41522-023-00404-5 |
| spellingShingle | Hakdong Shin Keith A. Martinez Nora Henderson Melanie Jay William Schweizer Debby Bogaert Gwoncheol Park Nicholas A. Bokulich Martin J. Blaser Maria Gloria Dominguez-Bello Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partum npj Biofilms and Microbiomes |
| title | Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partum |
| title_full | Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partum |
| title_fullStr | Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partum |
| title_full_unstemmed | Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partum |
| title_short | Partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post-partum |
| title_sort | partial convergence of the human vaginal and rectal maternal microbiota in late gestation and early post partum |
| url | https://doi.org/10.1038/s41522-023-00404-5 |
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