An overview of ATP synthase, inhibitors, and their toxicity
Mitochondrial complex V (ATP synthase) is a remarkable molecular motor crucial in generating ATP and sustaining mitochondrial function. Its importance in cellular metabolism cannot be overstated, as malfunction of ATP synthase has been linked to various pathological conditions. Both natural and synt...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023096676 |
| _version_ | 1797429615567831040 |
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| author | Arwa R. Althaher Mohammad Alwahsh |
| author_facet | Arwa R. Althaher Mohammad Alwahsh |
| author_sort | Arwa R. Althaher |
| collection | DOAJ |
| description | Mitochondrial complex V (ATP synthase) is a remarkable molecular motor crucial in generating ATP and sustaining mitochondrial function. Its importance in cellular metabolism cannot be overstated, as malfunction of ATP synthase has been linked to various pathological conditions. Both natural and synthetic ATP synthase inhibitors have been extensively studied, revealing their inhibitory sites and modes of action. These findings have opened exciting avenues for developing new therapeutics and discovering new pesticides and herbicides to safeguard global food supplies. However, it is essential to remember that these compounds can also adversely affect human and animal health, impacting vital organs such as the nervous system, heart, and kidneys. This review aims to provide a comprehensive overview of mitochondrial ATP synthase, its structural and functional features, and the most common inhibitors and their potential toxicities. |
| first_indexed | 2024-03-09T09:16:43Z |
| format | Article |
| id | doaj.art-48aea6c1ed524f58b0cb98d9395a4279 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:16:43Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-48aea6c1ed524f58b0cb98d9395a42792023-12-02T07:05:59ZengElsevierHeliyon2405-84402023-11-01911e22459An overview of ATP synthase, inhibitors, and their toxicityArwa R. Althaher0Mohammad Alwahsh1Corresponding author.; Department of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, JordanDepartment of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, JordanMitochondrial complex V (ATP synthase) is a remarkable molecular motor crucial in generating ATP and sustaining mitochondrial function. Its importance in cellular metabolism cannot be overstated, as malfunction of ATP synthase has been linked to various pathological conditions. Both natural and synthetic ATP synthase inhibitors have been extensively studied, revealing their inhibitory sites and modes of action. These findings have opened exciting avenues for developing new therapeutics and discovering new pesticides and herbicides to safeguard global food supplies. However, it is essential to remember that these compounds can also adversely affect human and animal health, impacting vital organs such as the nervous system, heart, and kidneys. This review aims to provide a comprehensive overview of mitochondrial ATP synthase, its structural and functional features, and the most common inhibitors and their potential toxicities.http://www.sciencedirect.com/science/article/pii/S2405844023096676ATP synthaseElectron transport chainProton motive forceRotational catalysisATP synthase inhibitors |
| spellingShingle | Arwa R. Althaher Mohammad Alwahsh An overview of ATP synthase, inhibitors, and their toxicity Heliyon ATP synthase Electron transport chain Proton motive force Rotational catalysis ATP synthase inhibitors |
| title | An overview of ATP synthase, inhibitors, and their toxicity |
| title_full | An overview of ATP synthase, inhibitors, and their toxicity |
| title_fullStr | An overview of ATP synthase, inhibitors, and their toxicity |
| title_full_unstemmed | An overview of ATP synthase, inhibitors, and their toxicity |
| title_short | An overview of ATP synthase, inhibitors, and their toxicity |
| title_sort | overview of atp synthase inhibitors and their toxicity |
| topic | ATP synthase Electron transport chain Proton motive force Rotational catalysis ATP synthase inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023096676 |
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