Re-understanding and focusing on normoalbuminuric diabetic kidney disease
Diabetes mellitus (DM) has grown up to be an important issue of global public health because of its high incidence rate. About 25% of DM patients can develop diabetic foot/ulcers (DF/DFU). Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease (ESKD). DF/DFU and DKD are serious...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1077929/full |
| _version_ | 1811320004886396928 |
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| author | Na An Na An Bi-tao Wu Bi-tao Wu Yu-wei Yang Yu-wei Yang Zheng-hong Huang Jia-fu Feng Jia-fu Feng |
| author_facet | Na An Na An Bi-tao Wu Bi-tao Wu Yu-wei Yang Yu-wei Yang Zheng-hong Huang Jia-fu Feng Jia-fu Feng |
| author_sort | Na An |
| collection | DOAJ |
| description | Diabetes mellitus (DM) has grown up to be an important issue of global public health because of its high incidence rate. About 25% of DM patients can develop diabetic foot/ulcers (DF/DFU). Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease (ESKD). DF/DFU and DKD are serious complications of DM. Therefore, early diagnosis and timely prevention and treatment of DF/DFU and DKD are essential for the progress of DM. The clinical diagnosis and staging of DKD are mostly based on the urinary albumin excretion rate (UAER) and EGFR. However, clinically, DKD patients show normoalbuminuric diabetic kidney disease (NADKD) instead of clinical proteinuria. The old NADKD concept is no longer suitable and should be updated accordingly with the redefinition of normal proteinuria by NKF/FDA. Based on the relevant guidelines of DM and CKD and combined with the current situation of clinical research, the review described NADKD from the aspects of epidemiology, pathological mechanism, clinical characteristics, biomarkers, disease diagnosis, and the relationship with DF/DFU to arouse the new understanding of NADKD in the medical profession and pay attention to it. |
| first_indexed | 2024-04-13T12:51:58Z |
| format | Article |
| id | doaj.art-48aeb215a54d48748ae4065210c01715 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T12:51:58Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-48aeb215a54d48748ae4065210c017152022-12-22T02:46:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10779291077929Re-understanding and focusing on normoalbuminuric diabetic kidney diseaseNa An0Na An1Bi-tao Wu2Bi-tao Wu3Yu-wei Yang4Yu-wei Yang5Zheng-hong Huang6Jia-fu Feng7Jia-fu Feng8National Health Commission Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL), Mianyang, ChinaDepartments of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaNational Health Commission Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL), Mianyang, ChinaDepartments of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaNational Health Commission Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL), Mianyang, ChinaDepartments of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaCollege of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaNational Health Commission Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL), Mianyang, ChinaDepartments of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, ChinaDiabetes mellitus (DM) has grown up to be an important issue of global public health because of its high incidence rate. About 25% of DM patients can develop diabetic foot/ulcers (DF/DFU). Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease (ESKD). DF/DFU and DKD are serious complications of DM. Therefore, early diagnosis and timely prevention and treatment of DF/DFU and DKD are essential for the progress of DM. The clinical diagnosis and staging of DKD are mostly based on the urinary albumin excretion rate (UAER) and EGFR. However, clinically, DKD patients show normoalbuminuric diabetic kidney disease (NADKD) instead of clinical proteinuria. The old NADKD concept is no longer suitable and should be updated accordingly with the redefinition of normal proteinuria by NKF/FDA. Based on the relevant guidelines of DM and CKD and combined with the current situation of clinical research, the review described NADKD from the aspects of epidemiology, pathological mechanism, clinical characteristics, biomarkers, disease diagnosis, and the relationship with DF/DFU to arouse the new understanding of NADKD in the medical profession and pay attention to it.https://www.frontiersin.org/articles/10.3389/fendo.2022.1077929/fulldiabetic kidney diseasediabetes mellitusnormoalbuminuric diabetic kidney diseasediabetic footdiabetic foot ulcer |
| spellingShingle | Na An Na An Bi-tao Wu Bi-tao Wu Yu-wei Yang Yu-wei Yang Zheng-hong Huang Jia-fu Feng Jia-fu Feng Re-understanding and focusing on normoalbuminuric diabetic kidney disease Frontiers in Endocrinology diabetic kidney disease diabetes mellitus normoalbuminuric diabetic kidney disease diabetic foot diabetic foot ulcer |
| title | Re-understanding and focusing on normoalbuminuric diabetic kidney disease |
| title_full | Re-understanding and focusing on normoalbuminuric diabetic kidney disease |
| title_fullStr | Re-understanding and focusing on normoalbuminuric diabetic kidney disease |
| title_full_unstemmed | Re-understanding and focusing on normoalbuminuric diabetic kidney disease |
| title_short | Re-understanding and focusing on normoalbuminuric diabetic kidney disease |
| title_sort | re understanding and focusing on normoalbuminuric diabetic kidney disease |
| topic | diabetic kidney disease diabetes mellitus normoalbuminuric diabetic kidney disease diabetic foot diabetic foot ulcer |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1077929/full |
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