<i>Momordica charantia</i>-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis
Plant-derived extracellular vesicles are functional nanovesicles that have significant applications in both disease prevention and treatment, as well as for use as drug carriers. <i>Momordica charantia</i> is a widely consumed food that has both medicinal and nutritional properties and h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/17/6182 |
| _version_ | 1797582112359972864 |
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| author | Feng Wang Meng Yuan Chenqi Shao Nan Ji Haifeng Zhang Chunmei Li |
| author_facet | Feng Wang Meng Yuan Chenqi Shao Nan Ji Haifeng Zhang Chunmei Li |
| author_sort | Feng Wang |
| collection | DOAJ |
| description | Plant-derived extracellular vesicles are functional nanovesicles that have significant applications in both disease prevention and treatment, as well as for use as drug carriers. <i>Momordica charantia</i> is a widely consumed food that has both medicinal and nutritional properties and has shown intervention in diabetes and inflammation caused by oxidative damage. In this study, <i>Momordica charantia</i>-derived extracellular vesicles (MCEVs) were extracted and demonstrated to have excellent antioxidant activity by characterization, lipid composition analysis, protein domain analysis, and in vitro antioxidant measurement. In addition, in vivo studies indicated that the MCEVs could restore ulcerative colitis by regulating oxidation and inflammatory factors. Therefore, the antioxidant properties of MCEVs may be important in protecting the colon from inflammation, which provides new insights into the application of MCEVs as drugs or vectors for intervention in ulcerative colitis. |
| first_indexed | 2024-03-10T23:17:16Z |
| format | Article |
| id | doaj.art-48b1acc41bbf4ae88cb85e2d20054c27 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T23:17:16Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-48b1acc41bbf4ae88cb85e2d20054c272023-11-19T08:32:26ZengMDPI AGMolecules1420-30492023-08-012817618210.3390/molecules28176182<i>Momordica charantia</i>-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative ColitisFeng Wang0Meng Yuan1Chenqi Shao2Nan Ji3Haifeng Zhang4Chunmei Li5College of Tourism and Culinary Science, Yangzhou University, Yangzhou 225009, ChinaCollege of Tourism and Culinary Science, Yangzhou University, Yangzhou 225009, ChinaCollege of Tourism and Culinary Science, Yangzhou University, Yangzhou 225009, ChinaCollege of Tourism and Culinary Science, Yangzhou University, Yangzhou 225009, ChinaCollege of Tourism and Culinary Science, Yangzhou University, Yangzhou 225009, ChinaCollege of Tourism and Culinary Science, Yangzhou University, Yangzhou 225009, ChinaPlant-derived extracellular vesicles are functional nanovesicles that have significant applications in both disease prevention and treatment, as well as for use as drug carriers. <i>Momordica charantia</i> is a widely consumed food that has both medicinal and nutritional properties and has shown intervention in diabetes and inflammation caused by oxidative damage. In this study, <i>Momordica charantia</i>-derived extracellular vesicles (MCEVs) were extracted and demonstrated to have excellent antioxidant activity by characterization, lipid composition analysis, protein domain analysis, and in vitro antioxidant measurement. In addition, in vivo studies indicated that the MCEVs could restore ulcerative colitis by regulating oxidation and inflammatory factors. Therefore, the antioxidant properties of MCEVs may be important in protecting the colon from inflammation, which provides new insights into the application of MCEVs as drugs or vectors for intervention in ulcerative colitis.https://www.mdpi.com/1420-3049/28/17/6182extracellular vesicles<i>Momordica charantia</i>protein domain analysisantioxidantulcerative colitis |
| spellingShingle | Feng Wang Meng Yuan Chenqi Shao Nan Ji Haifeng Zhang Chunmei Li <i>Momordica charantia</i>-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis Molecules extracellular vesicles <i>Momordica charantia</i> protein domain analysis antioxidant ulcerative colitis |
| title | <i>Momordica charantia</i>-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis |
| title_full | <i>Momordica charantia</i>-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis |
| title_fullStr | <i>Momordica charantia</i>-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis |
| title_full_unstemmed | <i>Momordica charantia</i>-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis |
| title_short | <i>Momordica charantia</i>-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis |
| title_sort | i momordica charantia i derived extracellular vesicles provide antioxidant protection in ulcerative colitis |
| topic | extracellular vesicles <i>Momordica charantia</i> protein domain analysis antioxidant ulcerative colitis |
| url | https://www.mdpi.com/1420-3049/28/17/6182 |
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