Effect of Nano-Titana in Radiotherapy: An In vivo Animal Study
Background and purpose: Among different cancers, breast cancer has a high prevalence among women and radiotherapy is used as a treatment modality in which radio sensitizers are used to increase its efficiency. Nanoparticles are such sensitizers that enhance the efficiency of radiotherapy via creatio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2017-06-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-10145-en.html |
| _version_ | 1797943705114509312 |
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| author | Hamed Masumi Hadi Hasanzadeh Mostafa Rezaei-Tavirani Majid Jadidi Alireza Nikoofar Reza Nasr Amir Darbandi-Azar Ahmad Bitarafan Rajabi Vahid Semnani |
| author_facet | Hamed Masumi Hadi Hasanzadeh Mostafa Rezaei-Tavirani Majid Jadidi Alireza Nikoofar Reza Nasr Amir Darbandi-Azar Ahmad Bitarafan Rajabi Vahid Semnani |
| author_sort | Hamed Masumi |
| collection | DOAJ |
| description | Background and purpose: Among different cancers, breast cancer has a high prevalence among women and radiotherapy is used as a treatment modality in which radio sensitizers are used to increase its efficiency. Nanoparticles are such sensitizers that enhance the efficiency of radiotherapy via creation of free radicals and induction of oxidative stress. This study aimed at evaluating the synergistic effect of radiation therapy and TiO2 nanoparticles on animal models of breast cancer.
Materials and methods: After induction of breast adenocarcinoma tumors in Balb/C, the animals were divided into several groups as control, rutile and anatase injections at 5mg/kg and 10mg/kg doses/with and without radiotherapy. Then, the efficiency of treatment was evaluated.
Results: In groups receiving anatase nanoparticles with and without radiation, the values for tumor volume, relative volume and relative volume percentage showed a small increase and a considerable reduction, respectively. In rutile groups with and without radiation, these values showed a small increase and a considerable increase, respectively. IR value reduced to negative value and then increased to zero and positive in anatase groups with and without radiation. This parameter had little changes in rutile groups with and without radiation.
Conclusion: Titanium dioxide nanoparticles increased sensitivity of tumor cells to radiation therapy due to ROS production. Compared with rutile crystals, anatase crystals have intense effect because of having a larger surface area and higher photocatalytic activity. |
| first_indexed | 2024-04-10T20:28:25Z |
| format | Article |
| id | doaj.art-48b29745db9049af8252fb93563375db |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:28:25Z |
| publishDate | 2017-06-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-48b29745db9049af8252fb93563375db2023-01-25T07:52:57ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792017-06-0127149113Effect of Nano-Titana in Radiotherapy: An In vivo Animal StudyHamed Masumi0Hadi Hasanzadeh1Mostafa Rezaei-Tavirani2Majid Jadidi3Alireza Nikoofar4Reza Nasr5Amir Darbandi-Azar6Ahmad Bitarafan Rajabi7Vahid Semnani8 Background and purpose: Among different cancers, breast cancer has a high prevalence among women and radiotherapy is used as a treatment modality in which radio sensitizers are used to increase its efficiency. Nanoparticles are such sensitizers that enhance the efficiency of radiotherapy via creation of free radicals and induction of oxidative stress. This study aimed at evaluating the synergistic effect of radiation therapy and TiO2 nanoparticles on animal models of breast cancer. Materials and methods: After induction of breast adenocarcinoma tumors in Balb/C, the animals were divided into several groups as control, rutile and anatase injections at 5mg/kg and 10mg/kg doses/with and without radiotherapy. Then, the efficiency of treatment was evaluated. Results: In groups receiving anatase nanoparticles with and without radiation, the values for tumor volume, relative volume and relative volume percentage showed a small increase and a considerable reduction, respectively. In rutile groups with and without radiation, these values showed a small increase and a considerable increase, respectively. IR value reduced to negative value and then increased to zero and positive in anatase groups with and without radiation. This parameter had little changes in rutile groups with and without radiation. Conclusion: Titanium dioxide nanoparticles increased sensitivity of tumor cells to radiation therapy due to ROS production. Compared with rutile crystals, anatase crystals have intense effect because of having a larger surface area and higher photocatalytic activity.http://jmums.mazums.ac.ir/article-1-10145-en.htmlradiotherapyradiation sensitizertio2 nanoparticle |
| spellingShingle | Hamed Masumi Hadi Hasanzadeh Mostafa Rezaei-Tavirani Majid Jadidi Alireza Nikoofar Reza Nasr Amir Darbandi-Azar Ahmad Bitarafan Rajabi Vahid Semnani Effect of Nano-Titana in Radiotherapy: An In vivo Animal Study Journal of Mazandaran University of Medical Sciences radiotherapy radiation sensitizer tio2 nanoparticle |
| title | Effect of Nano-Titana in Radiotherapy: An In vivo Animal Study |
| title_full | Effect of Nano-Titana in Radiotherapy: An In vivo Animal Study |
| title_fullStr | Effect of Nano-Titana in Radiotherapy: An In vivo Animal Study |
| title_full_unstemmed | Effect of Nano-Titana in Radiotherapy: An In vivo Animal Study |
| title_short | Effect of Nano-Titana in Radiotherapy: An In vivo Animal Study |
| title_sort | effect of nano titana in radiotherapy an in vivo animal study |
| topic | radiotherapy radiation sensitizer tio2 nanoparticle |
| url | http://jmums.mazums.ac.ir/article-1-10145-en.html |
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