The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis)
Abstract Introduction This article examines the potential of using liquid biopsy with piRNAs to study cancer survival outcomes. While previous studies have explored the relationship between piRNA expression and cancer patient outcomes, a comprehensive investigation is still lacking. To address this...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-024-12180-2 |
| _version_ | 1797199395097149440 |
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| author | Mohammad Taghizadeh Tohid Jafari-Koshki Vahid Jafarlou Mortaza Raeisi Leila Alizadeh Yousef Roosta Somaieh Matin Rahele Jabari Daniel Sur Abbas Karimi |
| author_facet | Mohammad Taghizadeh Tohid Jafari-Koshki Vahid Jafarlou Mortaza Raeisi Leila Alizadeh Yousef Roosta Somaieh Matin Rahele Jabari Daniel Sur Abbas Karimi |
| author_sort | Mohammad Taghizadeh |
| collection | DOAJ |
| description | Abstract Introduction This article examines the potential of using liquid biopsy with piRNAs to study cancer survival outcomes. While previous studies have explored the relationship between piRNA expression and cancer patient outcomes, a comprehensive investigation is still lacking. To address this gap, we conducted a systematic review and meta-analysis of existing literature. Methods We searched major online databases up to February 2024 to identify articles reporting on the role of piRNA in cancer patient survival outcomes. Our meta-analysis used a random-effects model to pool hazard ratios with 95% confidence intervals (CI) and assess the prognostic value of deregulated piRNA-823. For survival analysis, the Kaplan–Meier method and COX analysis were used. Results Out of 6104 articles screened, 20 met our inclusion criteria. Our analysis revealed that dysregulated piRNA expression is associated with cancer patient survival outcomes. Specifically, our meta-analysis found that overexpression of piR-823 is significantly linked with poorer overall survival in patients with colorectal cancer and renal cell cancer (HR: 3.82, 95% CI = [1.81, 8.04], I2 = 70%). Conclusion Our findings suggest that various piRNAs may play a role in cancer survival outcomes and that piRNA-823 in particular holds promise as a prognostic biomarker for multiple human cancers. Implications for cancer survivors Our systematic review and meta-analysis of piRNA-823 has important implications for cancer survivors. Our findings suggest that piRNA-823 can be used as a prognostic biomarker for predicting cancer recurrence and survival rates. This information can help clinicians develop personalized treatment plans for cancer survivors, which can improve their quality of life and reduce the risk of recurrence. |
| first_indexed | 2024-04-24T07:15:04Z |
| format | Article |
| id | doaj.art-48b2c5e7ed6449f8b327cfaea7a04174 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-24T07:15:04Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-48b2c5e7ed6449f8b327cfaea7a041742024-04-21T11:21:36ZengBMCBMC Cancer1471-24072024-04-0124111410.1186/s12885-024-12180-2The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis)Mohammad Taghizadeh0Tohid Jafari-Koshki1Vahid Jafarlou2Mortaza Raeisi3Leila Alizadeh4Yousef Roosta5Somaieh Matin6Rahele Jabari7Daniel Sur8Abbas Karimi9Department of Molecular Medicine, Faculty of Advanced Medical School, Tabriz University of Medical SciencesDepartment of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical SciencesCancer Institute of Imam Khomeini Hospital, Tehran University of Medical ScienceHematology and Oncology Research Center, Tabriz University of Medical SciencesGastroenterology and Liver Diseases Research Center, Tabriz University of Medical SciencesDepartment of Internal Medicine, School of Medicine, Urmia University of Medical SciencesDepartment of Internal Medicine, School of Medicine, Ardabil University of Medical SciencesDepartment of Nutrition Science, Faculty of Medical Science, Urmia University of Medical ScienceDepartment of Oncology, The Oncology Institute “Prof. Dr. Ion Chiricu¸tă”Department of Molecular Medicine, Faculty of Advanced Medical School, Tabriz University of Medical SciencesAbstract Introduction This article examines the potential of using liquid biopsy with piRNAs to study cancer survival outcomes. While previous studies have explored the relationship between piRNA expression and cancer patient outcomes, a comprehensive investigation is still lacking. To address this gap, we conducted a systematic review and meta-analysis of existing literature. Methods We searched major online databases up to February 2024 to identify articles reporting on the role of piRNA in cancer patient survival outcomes. Our meta-analysis used a random-effects model to pool hazard ratios with 95% confidence intervals (CI) and assess the prognostic value of deregulated piRNA-823. For survival analysis, the Kaplan–Meier method and COX analysis were used. Results Out of 6104 articles screened, 20 met our inclusion criteria. Our analysis revealed that dysregulated piRNA expression is associated with cancer patient survival outcomes. Specifically, our meta-analysis found that overexpression of piR-823 is significantly linked with poorer overall survival in patients with colorectal cancer and renal cell cancer (HR: 3.82, 95% CI = [1.81, 8.04], I2 = 70%). Conclusion Our findings suggest that various piRNAs may play a role in cancer survival outcomes and that piRNA-823 in particular holds promise as a prognostic biomarker for multiple human cancers. Implications for cancer survivors Our systematic review and meta-analysis of piRNA-823 has important implications for cancer survivors. Our findings suggest that piRNA-823 can be used as a prognostic biomarker for predicting cancer recurrence and survival rates. This information can help clinicians develop personalized treatment plans for cancer survivors, which can improve their quality of life and reduce the risk of recurrence.https://doi.org/10.1186/s12885-024-12180-2piRNACancerSurvivalPrognosisSystematic reviewMeta-analysis |
| spellingShingle | Mohammad Taghizadeh Tohid Jafari-Koshki Vahid Jafarlou Mortaza Raeisi Leila Alizadeh Yousef Roosta Somaieh Matin Rahele Jabari Daniel Sur Abbas Karimi The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis) BMC Cancer piRNA Cancer Survival Prognosis Systematic review Meta-analysis |
| title | The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis) |
| title_full | The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis) |
| title_fullStr | The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis) |
| title_full_unstemmed | The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis) |
| title_short | The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis) |
| title_sort | role of pirnas in predicting and prognosing in cancer a focus on pirna 823 a systematic review and meta analysis |
| topic | piRNA Cancer Survival Prognosis Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12885-024-12180-2 |
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