Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant
In patients with autoimmune coagulation factor deficiency (AiCFD), the production of autoantibodies that inhibit coagulation factors in the blood reduces the activity of those relevant coagulation factors, resulting in severe bleeding symptoms. Recently, reports of patients with AiCFD have noted the...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-08-01
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| Series: | Exploration of Immunology |
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| Online Access: | https://www.explorationpub.com/Journals/ei/Article/1003103 |
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| author | Masahiro Ieko Kazumasa Ohmura Sumiyoshi Naito Mika Yoshida Hisaomi Sasaki Tsuyoshi Sato Norifumi Sugawara Nobuhiko Takahashi Akitada Ichinose |
| author_facet | Masahiro Ieko Kazumasa Ohmura Sumiyoshi Naito Mika Yoshida Hisaomi Sasaki Tsuyoshi Sato Norifumi Sugawara Nobuhiko Takahashi Akitada Ichinose |
| author_sort | Masahiro Ieko |
| collection | DOAJ |
| description | In patients with autoimmune coagulation factor deficiency (AiCFD), the production of autoantibodies that inhibit coagulation factors in the blood reduces the activity of those relevant coagulation factors, resulting in severe bleeding symptoms. Recently, reports of patients with AiCFD have noted the concomitant detection of lupus anticoagulant (LA), a risk factor for thrombosis. LA-positive patients may show bleeding symptoms due to decreased activity of coagulation factor II (FII) caused by autoantibodies against FII, in addition to thrombotic symptoms, a condition termed LA-hypoprothrombinemia syndrome (LAHPS). Anti-FII antibodies in LAHPS cases are frequently cleared antibodies that can be detected using immunological techniques, such as enzyme-linked immunosorbent assay (ELISA). Recently, several cases of coagulation FV inhibitors, known as autoimmune FV deficiency, have been reported. Some of these cases may be complicated by LA, which can cause thrombosis. False-positive results for anticoagulant inhibitors are known to occur in LA cases; therefore, immunological confirmation of antibodies against coagulation factors is recommended. Additionally, acquired hemophilia A (AHA), caused by autoantibodies against FVIII, is a typical acquired hemorrhagic diathesis, although affected patients may present with thrombosis associated with LA. Thus, it is important to remember that hemorrhagic diathesis due to autoantibodies against clotting factors can also result in thrombosis, as demonstrated by the co-detection of LA. When clotting factor inhibitors are detected in LA-positive individuals, it is important to confirm the presence of autoantibodies against coagulation factors using immunological methods, such as ELISA, to avoid false-positive results. |
| first_indexed | 2024-03-12T02:19:05Z |
| format | Article |
| id | doaj.art-48b2cbefa8b641c79e5ce162032deb0f |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-03-12T02:19:05Z |
| publishDate | 2023-08-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-48b2cbefa8b641c79e5ce162032deb0f2023-09-06T06:18:45ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552023-08-013428629910.37349/ei.2023.00103Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulantMasahiro Ieko0Kazumasa Ohmura1Sumiyoshi Naito2Mika Yoshida3Hisaomi Sasaki4Tsuyoshi Sato5Norifumi Sugawara6Nobuhiko Takahashi7Akitada Ichinose8Department of Hematology Laboratory, Iwate Prefectural Chubu Hospital, Kitakami 024-8507, Japan; Department of Clinical Laboratory, Iwate Prefectural Chubu Hospital, Kitakami 024-8507, JapanDepartment of Internal Medicine, School of Dentistry, Health Sciences University of Hokkaido, Ishikari 061-0293, JapanDepartmrnt of Clinical Laboratory, Health Sciences University of Hokkaido Hospital, Sapporo 001-8071, JapanDepartmrnt of Clinical Laboratory, Health Sciences University of Hokkaido Hospital, Sapporo 001-8071, JapanDepartment of Clinical Laboratory, Iwate Prefectural Chubu Hospital, Kitakami 024-8507, JapanDepartment of Hematology Laboratory, Iwate Prefectural Chubu Hospital, Kitakami 024-8507, JapanDepartment of Hematology Laboratory, Iwate Prefectural Chubu Hospital, Kitakami 024-8507, JapanDepartment of Internal Medicine, School of Dentistry, Health Sciences University of Hokkaido, Ishikari 061-0293, JapanDepartment of Molecular Patho-Biochemistry, Yamagata University School of Medicine, Yamagata 990-9585, JapanIn patients with autoimmune coagulation factor deficiency (AiCFD), the production of autoantibodies that inhibit coagulation factors in the blood reduces the activity of those relevant coagulation factors, resulting in severe bleeding symptoms. Recently, reports of patients with AiCFD have noted the concomitant detection of lupus anticoagulant (LA), a risk factor for thrombosis. LA-positive patients may show bleeding symptoms due to decreased activity of coagulation factor II (FII) caused by autoantibodies against FII, in addition to thrombotic symptoms, a condition termed LA-hypoprothrombinemia syndrome (LAHPS). Anti-FII antibodies in LAHPS cases are frequently cleared antibodies that can be detected using immunological techniques, such as enzyme-linked immunosorbent assay (ELISA). Recently, several cases of coagulation FV inhibitors, known as autoimmune FV deficiency, have been reported. Some of these cases may be complicated by LA, which can cause thrombosis. False-positive results for anticoagulant inhibitors are known to occur in LA cases; therefore, immunological confirmation of antibodies against coagulation factors is recommended. Additionally, acquired hemophilia A (AHA), caused by autoantibodies against FVIII, is a typical acquired hemorrhagic diathesis, although affected patients may present with thrombosis associated with LA. Thus, it is important to remember that hemorrhagic diathesis due to autoantibodies against clotting factors can also result in thrombosis, as demonstrated by the co-detection of LA. When clotting factor inhibitors are detected in LA-positive individuals, it is important to confirm the presence of autoantibodies against coagulation factors using immunological methods, such as ELISA, to avoid false-positive results.https://www.explorationpub.com/Journals/ei/Article/1003103lupus anticoagulant-hypoprothrombinemia syndromeautoimmune coagulation factor deficiencylupus anticoagulant-hypoprothrombinemia syndrome-vacquired hemophilia alupus anticoagulantthrombosis |
| spellingShingle | Masahiro Ieko Kazumasa Ohmura Sumiyoshi Naito Mika Yoshida Hisaomi Sasaki Tsuyoshi Sato Norifumi Sugawara Nobuhiko Takahashi Akitada Ichinose Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant Exploration of Immunology lupus anticoagulant-hypoprothrombinemia syndrome autoimmune coagulation factor deficiency lupus anticoagulant-hypoprothrombinemia syndrome-v acquired hemophilia a lupus anticoagulant thrombosis |
| title | Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant |
| title_full | Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant |
| title_fullStr | Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant |
| title_full_unstemmed | Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant |
| title_short | Considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant |
| title_sort | considerations for simultaneous detection of autoantibodies to coagulation factor and lupus anticoagulant |
| topic | lupus anticoagulant-hypoprothrombinemia syndrome autoimmune coagulation factor deficiency lupus anticoagulant-hypoprothrombinemia syndrome-v acquired hemophilia a lupus anticoagulant thrombosis |
| url | https://www.explorationpub.com/Journals/ei/Article/1003103 |
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