Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease

Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson’s disease

Abstract Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be consistently elevated in carriers of LR...

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Bibliographic Details
Main Authors: Sara Gomes, Alicia Garrido, Francesca Tonelli, Donina Obiang, Eduardo Tolosa, Maria José Martí, Javier Ruiz-Martínez, Ana Vinagre-Aragón, Haizea Hernandez-Eguiazu, Ioana Croitoru, Vicky L. Marshall, Theresa Koenig, Christoph Hotzy, Frank Hsieh, Marianna Sakalosh, Elizabeth Tengstrand, Shalini Padmanabhan, Kalpana Merchant, Christof Bruecke, Walter Pirker, Alexander Zimprich, Esther Sammler
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00482-4

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