Prevalence and Distribution of HPV Genotypes in Immunosuppressed Patients in Lorraine Region
Background: The primary objective of this work was to assess the prevalence and distribution of HPV genotypes in immunosuppressed patients, and to compare them with the French Monsonego cohort. Secondary objectives were to evaluate whether the risk of HPV infection was correlated with HIV viral load...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/12/2454 |
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| author | Margot Boudes Véronique Venard Thierry Routiot Marie Buzzi Floriane Maillot |
| author_facet | Margot Boudes Véronique Venard Thierry Routiot Marie Buzzi Floriane Maillot |
| author_sort | Margot Boudes |
| collection | DOAJ |
| description | Background: The primary objective of this work was to assess the prevalence and distribution of HPV genotypes in immunosuppressed patients, and to compare them with the French Monsonego cohort. Secondary objectives were to evaluate whether the risk of HPV infection was correlated with HIV viral load, CD4 cell count in HIV-infected patients and the type, number of immunosuppressive therapies or type of pathology (transplant vs. autoimmune diseases) in patients undergoing long-term immunosuppressive therapy. Methods: An observational, monocentric and historical study was conducted including all immunosuppressed patients having received an HPV testing, in the Laboratory of Virology, Nancy Regional Teaching Hospital Center, between 2014 and 2020. Immunosuppressed patients were either HIV-infected or received long-term immunosuppressive therapy. Results: In our cohort, the prevalence of HPV infection (75.6% vs. 16.1% <i>p</i> < 0.05), the proportion of patients with high-risk HPV infection (48.9% vs. 15.1% <i>p</i> < 0.05) and with multiple HPV infection (41.1% vs. 5.7% <i>p</i> < 0.05) were significantly higher than in the Monsonego cohort. HPV 52 (13%), 53 (13%) and 16 (10%) were the most common in the immunosuppressed population, while it was HPV 16, 42 and 51 in the Monsonego cohort. Conclusions: This study supports that a particular attention must be given to all the immunosuppressed patients for the screening and care of HPV-related diseases because of major modifications of HPV epidemiology compared with the overall population. |
| first_indexed | 2024-03-10T03:54:01Z |
| format | Article |
| id | doaj.art-48b551fd7bc74e01be872a6a9ef7f202 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T03:54:01Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-48b551fd7bc74e01be872a6a9ef7f2022023-11-23T10:58:10ZengMDPI AGViruses1999-49152021-12-011312245410.3390/v13122454Prevalence and Distribution of HPV Genotypes in Immunosuppressed Patients in Lorraine RegionMargot Boudes0Véronique Venard1Thierry Routiot2Marie Buzzi3Floriane Maillot4Department of Medical Gynecology, CHRU Nancy, 10 rue Heydenreich, 54000 Nancy, FranceFaculty of Medicine, University of Lorraine, 9 Avenue de la Forêt de Haye, 54505 Nancy, FranceDepartment of Obstetrics & Gynecology, CHRU Nancy, 10 rue Heydenreich, 54000 Nancy, FranceFaculty of Medicine, University of Lorraine, 9 Avenue de la Forêt de Haye, 54505 Nancy, FranceDepartment of Medical Gynecology, CHRU Nancy, 10 rue Heydenreich, 54000 Nancy, FranceBackground: The primary objective of this work was to assess the prevalence and distribution of HPV genotypes in immunosuppressed patients, and to compare them with the French Monsonego cohort. Secondary objectives were to evaluate whether the risk of HPV infection was correlated with HIV viral load, CD4 cell count in HIV-infected patients and the type, number of immunosuppressive therapies or type of pathology (transplant vs. autoimmune diseases) in patients undergoing long-term immunosuppressive therapy. Methods: An observational, monocentric and historical study was conducted including all immunosuppressed patients having received an HPV testing, in the Laboratory of Virology, Nancy Regional Teaching Hospital Center, between 2014 and 2020. Immunosuppressed patients were either HIV-infected or received long-term immunosuppressive therapy. Results: In our cohort, the prevalence of HPV infection (75.6% vs. 16.1% <i>p</i> < 0.05), the proportion of patients with high-risk HPV infection (48.9% vs. 15.1% <i>p</i> < 0.05) and with multiple HPV infection (41.1% vs. 5.7% <i>p</i> < 0.05) were significantly higher than in the Monsonego cohort. HPV 52 (13%), 53 (13%) and 16 (10%) were the most common in the immunosuppressed population, while it was HPV 16, 42 and 51 in the Monsonego cohort. Conclusions: This study supports that a particular attention must be given to all the immunosuppressed patients for the screening and care of HPV-related diseases because of major modifications of HPV epidemiology compared with the overall population.https://www.mdpi.com/1999-4915/13/12/2454human papillomavirusHPV genotypesimmunosuppressed patientsHIVimmunosuppressive therapy |
| spellingShingle | Margot Boudes Véronique Venard Thierry Routiot Marie Buzzi Floriane Maillot Prevalence and Distribution of HPV Genotypes in Immunosuppressed Patients in Lorraine Region Viruses human papillomavirus HPV genotypes immunosuppressed patients HIV immunosuppressive therapy |
| title | Prevalence and Distribution of HPV Genotypes in Immunosuppressed Patients in Lorraine Region |
| title_full | Prevalence and Distribution of HPV Genotypes in Immunosuppressed Patients in Lorraine Region |
| title_fullStr | Prevalence and Distribution of HPV Genotypes in Immunosuppressed Patients in Lorraine Region |
| title_full_unstemmed | Prevalence and Distribution of HPV Genotypes in Immunosuppressed Patients in Lorraine Region |
| title_short | Prevalence and Distribution of HPV Genotypes in Immunosuppressed Patients in Lorraine Region |
| title_sort | prevalence and distribution of hpv genotypes in immunosuppressed patients in lorraine region |
| topic | human papillomavirus HPV genotypes immunosuppressed patients HIV immunosuppressive therapy |
| url | https://www.mdpi.com/1999-4915/13/12/2454 |
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