Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function
Panic disorder (PD) causes serious functional damage and disability and accelerates the process of individual aging. The pathological basis of PD is the same as that of age-related diseases, which is proposed as a new viewpoint in recent years. Memory decline and social functional impairment are com...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.835963/full |
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| author | Huachen Ding Huachen Ding Yuan Zhong Na Liu Na Liu Huiqin Wu Huiqin Wu Huazhen Xu Huazhen Xu Yun Wu Yun Wu Yun Wu Yun Wu Gang Liu Gang Liu Gang Liu Shiting Yuan Shiting Yuan Qigang Zhou Chun Wang Chun Wang Chun Wang Chun Wang |
| author_facet | Huachen Ding Huachen Ding Yuan Zhong Na Liu Na Liu Huiqin Wu Huiqin Wu Huazhen Xu Huazhen Xu Yun Wu Yun Wu Yun Wu Yun Wu Gang Liu Gang Liu Gang Liu Shiting Yuan Shiting Yuan Qigang Zhou Chun Wang Chun Wang Chun Wang Chun Wang |
| author_sort | Huachen Ding |
| collection | DOAJ |
| description | Panic disorder (PD) causes serious functional damage and disability and accelerates the process of individual aging. The pathological basis of PD is the same as that of age-related diseases, which is proposed as a new viewpoint in recent years. Memory decline and social functional impairment are common manifestations of accelerated aging in PD. The function of telomerase reverse transcriptase (TERT) and telomere length (TL) is abnormal in patients with aging and PD. However, the molecular mechanism behind remains unclear. The purpose of this study was to explore the relationship between TERT gene expression (including DNA methylation) and the changes in PD aging characteristics (memory and social function). By TERT gene knockout mice, we found that loss of TERT attenuated the acquisition of recent fear memory during contextual fear conditioning. This study reported that a significantly lower methylation level of human TERT (hTERT) gene was detected in PD patients compared with healthy control and particularly decreased CpG methylation in the promoter region of hTERT was associated with the clinical characteristics in PD. Regional homogeneity (ReHo) analysis showed that the methylation of hTERT (cg1295648) influenced social function of PD patients through moderating the function of the left postcentral gyrus (PCG). This indicates that the hTERT gene may play an important role in the pathological basis of PD aging and may become a biological marker for evaluating PD aging. These findings provide multidimensional evidence for the underlying genetic and pathological mechanisms of PD. |
| first_indexed | 2024-04-12T07:40:55Z |
| format | Article |
| id | doaj.art-48b5522670684264b744b6b1df6f750c |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T07:40:55Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-48b5522670684264b744b6b1df6f750c2022-12-22T03:41:49ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.835963835963Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain functionHuachen Ding0Huachen Ding1Yuan Zhong2Na Liu3Na Liu4Huiqin Wu5Huiqin Wu6Huazhen Xu7Huazhen Xu8Yun Wu9Yun Wu10Yun Wu11Yun Wu12Gang Liu13Gang Liu14Gang Liu15Shiting Yuan16Shiting Yuan17Qigang Zhou18Chun Wang19Chun Wang20Chun Wang21Chun Wang22Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaFunctional Brain Imaging Institute of Nanjing Medical University, Nanjing, ChinaSchool of Psychology, Nanjing Normal University, Nanjing, ChinaNanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaCognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaFunctional Brain Imaging Institute of Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaFunctional Brain Imaging Institute of Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaFunctional Brain Imaging Institute of Nanjing Medical University, Nanjing, ChinaSchool of Psychology, Nanjing Normal University, Nanjing, ChinaCognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaFunctional Brain Imaging Institute of Nanjing Medical University, Nanjing, ChinaCognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaFunctional Brain Imaging Institute of Nanjing Medical University, Nanjing, ChinaDepartment of Clinical Pharmacology, School of Pharmacy, Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, ChinaFunctional Brain Imaging Institute of Nanjing Medical University, Nanjing, ChinaSchool of Psychology, Nanjing Normal University, Nanjing, ChinaCognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, ChinaPanic disorder (PD) causes serious functional damage and disability and accelerates the process of individual aging. The pathological basis of PD is the same as that of age-related diseases, which is proposed as a new viewpoint in recent years. Memory decline and social functional impairment are common manifestations of accelerated aging in PD. The function of telomerase reverse transcriptase (TERT) and telomere length (TL) is abnormal in patients with aging and PD. However, the molecular mechanism behind remains unclear. The purpose of this study was to explore the relationship between TERT gene expression (including DNA methylation) and the changes in PD aging characteristics (memory and social function). By TERT gene knockout mice, we found that loss of TERT attenuated the acquisition of recent fear memory during contextual fear conditioning. This study reported that a significantly lower methylation level of human TERT (hTERT) gene was detected in PD patients compared with healthy control and particularly decreased CpG methylation in the promoter region of hTERT was associated with the clinical characteristics in PD. Regional homogeneity (ReHo) analysis showed that the methylation of hTERT (cg1295648) influenced social function of PD patients through moderating the function of the left postcentral gyrus (PCG). This indicates that the hTERT gene may play an important role in the pathological basis of PD aging and may become a biological marker for evaluating PD aging. These findings provide multidimensional evidence for the underlying genetic and pathological mechanisms of PD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.835963/fulltelomerase reverse transcriptase geneDNA methylationagingpanic disorderregional homogeneity |
| spellingShingle | Huachen Ding Huachen Ding Yuan Zhong Na Liu Na Liu Huiqin Wu Huiqin Wu Huazhen Xu Huazhen Xu Yun Wu Yun Wu Yun Wu Yun Wu Gang Liu Gang Liu Gang Liu Shiting Yuan Shiting Yuan Qigang Zhou Chun Wang Chun Wang Chun Wang Chun Wang Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function Frontiers in Aging Neuroscience telomerase reverse transcriptase gene DNA methylation aging panic disorder regional homogeneity |
| title | Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function |
| title_full | Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function |
| title_fullStr | Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function |
| title_full_unstemmed | Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function |
| title_short | Panic disorder aging characteristics: The role of telomerase reverse transcriptase gene and brain function |
| title_sort | panic disorder aging characteristics the role of telomerase reverse transcriptase gene and brain function |
| topic | telomerase reverse transcriptase gene DNA methylation aging panic disorder regional homogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.835963/full |
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