Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement
The administration of approved antifungals via unapproved formulations or administration routes (such as aerosol, direct injection, irrigation, topical formulation and antifungal-impregnated orthopedic beads or cement) may be resorted to in an attempt to optimize drug exposure while minimizing toxic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/8/2/212 |
| _version_ | 1797478895867396096 |
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| author | Richard H. Drew John R. Perfect |
| author_facet | Richard H. Drew John R. Perfect |
| author_sort | Richard H. Drew |
| collection | DOAJ |
| description | The administration of approved antifungals via unapproved formulations or administration routes (such as aerosol, direct injection, irrigation, topical formulation and antifungal-impregnated orthopedic beads or cement) may be resorted to in an attempt to optimize drug exposure while minimizing toxicities and/or drug interactions associated with conventional (systemic) administrations. Existing data regarding such administrations are mostly restricted to uncontrolled case reports of patients with diseases refractory to conventional therapies. Attribution of efficacy and tolerability is most often problematic. This review updates prior published summaries, reflecting the most recent data and its application by available prevention and treatment guidelines for invasive fungal infections. Of the various dosage forms and antifungals, perhaps none is more widely reported than the application of amphotericin B-containing aerosols for the prevention of invasive mold infections (notably <i>Aspergillus</i> spp.). |
| first_indexed | 2024-03-09T21:38:07Z |
| format | Article |
| id | doaj.art-48b6097bf2214e3c9b85c824fb63be9a |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T21:38:07Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-48b6097bf2214e3c9b85c824fb63be9a2023-11-23T20:38:35ZengMDPI AGJournal of Fungi2309-608X2022-02-018221210.3390/jof8020212Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated CementRichard H. Drew0John R. Perfect1Division of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USADivision of Infectious Diseases, Duke University School of Medicine, Durham, NC 27710, USAThe administration of approved antifungals via unapproved formulations or administration routes (such as aerosol, direct injection, irrigation, topical formulation and antifungal-impregnated orthopedic beads or cement) may be resorted to in an attempt to optimize drug exposure while minimizing toxicities and/or drug interactions associated with conventional (systemic) administrations. Existing data regarding such administrations are mostly restricted to uncontrolled case reports of patients with diseases refractory to conventional therapies. Attribution of efficacy and tolerability is most often problematic. This review updates prior published summaries, reflecting the most recent data and its application by available prevention and treatment guidelines for invasive fungal infections. Of the various dosage forms and antifungals, perhaps none is more widely reported than the application of amphotericin B-containing aerosols for the prevention of invasive mold infections (notably <i>Aspergillus</i> spp.).https://www.mdpi.com/2309-608X/8/2/212antifungalsaerosolsirrigationorthopedic cement |
| spellingShingle | Richard H. Drew John R. Perfect Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement Journal of Fungi antifungals aerosols irrigation orthopedic cement |
| title | Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement |
| title_full | Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement |
| title_fullStr | Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement |
| title_full_unstemmed | Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement |
| title_short | Conventional Antifungals for Invasive Infections Delivered by Unconventional Methods; Aerosols, Irrigants, Directed Injections and Impregnated Cement |
| title_sort | conventional antifungals for invasive infections delivered by unconventional methods aerosols irrigants directed injections and impregnated cement |
| topic | antifungals aerosols irrigation orthopedic cement |
| url | https://www.mdpi.com/2309-608X/8/2/212 |
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