BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone

BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone

Blood oxygen level dependent (BOLD) imaging in awake mice was used to identify differences in brain activity between wild-type, and Mu (µ) opioid receptor knock-outs (MuKO) in response to oxycodone (OXY). Using a segmented, annotated MRI mouse atlas and computational analysis, patterns of integrate...

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Bibliographic Details
Main Authors: Kelsey Moore, Dan Madularu, Sade Iriah, Jason Richard Yee, Praveen Kulkarni, Emmanuel Darcq, Brigitte L. Kieffer, Craig F Ferris
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Neuroscience
Subjects:
Oxycodone
Addiction
knockout mouse
mu-opioid receptor
BOLD fMRI
opioid receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00471/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00471/full

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