The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway

The neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway

Abstract Background Colorectal cancer (CRC) remains largely incurable when diagnosed at the metastatic stage. Despite some advances in precision medicine for this disease in recent years, new molecular targets, as well as prognostic/predictive markers, are highly needed. Neuroligin 1 (NLGN1) is a tr...

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Bibliographic Details
Main Authors: Margherita Pergolizzi, Laura Bizzozero, Federica Maione, Elena Maldi, Claudio Isella, Marco Macagno, Elisa Mariella, Alberto Bardelli, Enzo Medico, Caterina Marchiò, Guido Serini, Federica Di Nicolantonio, Federico Bussolino, Marco Arese
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Neuroligin 1
tumor budding
intravasation/extravasation
APC
metastasis
WNT pathway
Online Access:https://doi.org/10.1186/s13046-022-02465-4

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