Principles of Rational COVID-19 Therapy in Pediatrics
The purpose of this review was to conduct a comparative assessment of the concepts of therapy for pediatric patients with COVID-19 in the framework of global clinical practice. A structural analysis of the range of drugs and treatment strategies in the context of etiotropic, pathogenetic, and sympto...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/14/4731 |
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| author | Oksana D. Nemyatykh Marina A. Maistrenko Dina D. Demchenko Igor A. Narkevich Sergey V. Okovityi Vladimir N. Timchenko |
| author_facet | Oksana D. Nemyatykh Marina A. Maistrenko Dina D. Demchenko Igor A. Narkevich Sergey V. Okovityi Vladimir N. Timchenko |
| author_sort | Oksana D. Nemyatykh |
| collection | DOAJ |
| description | The purpose of this review was to conduct a comparative assessment of the concepts of therapy for pediatric patients with COVID-19 in the framework of global clinical practice. A structural analysis of the range of drugs and treatment strategies in the context of etiotropic, pathogenetic, and symptomatic therapy has shown that in the global context and in real clinical practice, the etiotropic-pathogenetic approach based on information about the effectiveness of individual medical technologies prevails today. It has been established that eight international nonproprietary/grouping names are present in international practice as means of etiotropic therapy for pediatric patients with COVID-19, and 18 positions are used for pathogenetic therapy. In terms of frequency of occurrence, the leading positions are occupied by remdesivir and the combination of nirmatrelvir with ritonavir, as well as dexamethasone and tocilizumab. The paper emphasizes the relevance of research in the field of evaluating the effectiveness of individual treatment regimens as well as the analysis of the delayed consequences of pathology suffered in childhood under the conditions of using various approaches to pharmacotherapy. |
| first_indexed | 2024-03-11T00:57:37Z |
| format | Article |
| id | doaj.art-48b9c0cd336445539751146a629e9692 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:57:37Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-48b9c0cd336445539751146a629e96922023-11-18T19:53:08ZengMDPI AGJournal of Clinical Medicine2077-03832023-07-011214473110.3390/jcm12144731Principles of Rational COVID-19 Therapy in PediatricsOksana D. Nemyatykh0Marina A. Maistrenko1Dina D. Demchenko2Igor A. Narkevich3Sergey V. Okovityi4Vladimir N. Timchenko5Department of Management and Economics of Pharmacy, Faculty of Pharmacy, Saint-Petersburg State Chemical Pharmaceutical University, Ministry of Health of Russia, Prof. Popova Str., 14 Lit. A, 197376 Saint-Petersburg, RussiaDepartment of Management and Economics of Pharmacy, Faculty of Pharmacy, Ryazan State Medical University Named after Academician I.P. Pavlov, Ministry of Health of Russia, Vysokovoltnaya Str., 9, 390026 Ryazan, RussiaDepartment of Management and Economics of Pharmacy, Faculty of Pharmacy, Saint-Petersburg State Chemical Pharmaceutical University, Ministry of Health of Russia, Prof. Popova Str., 14 Lit. A, 197376 Saint-Petersburg, RussiaDepartment of Management and Economics of Pharmacy, Faculty of Pharmacy, Saint-Petersburg State Chemical Pharmaceutical University, Ministry of Health of Russia, Prof. Popova Str., 14 Lit. A, 197376 Saint-Petersburg, RussiaDepartment of Pharmacology and Clinical Pharmacology, Faculty of Pharmacy, Saint-Petersburg State Chemical Pharmaceutical University, Ministry of Health of Russia, Prof. Popova Str., 14 Lit. A, 197376 Saint-Petersburg, RussiaDepartment of Infectious Diseases in Children Named after Prof. M.G. Danilevich, Faculty of Pediatrics, Saint-Petersburg State Pediatric Medical University, Ministry of Health of Russia, Litovskaya Str., 2, 194100 Saint-Petersburg, RussiaThe purpose of this review was to conduct a comparative assessment of the concepts of therapy for pediatric patients with COVID-19 in the framework of global clinical practice. A structural analysis of the range of drugs and treatment strategies in the context of etiotropic, pathogenetic, and symptomatic therapy has shown that in the global context and in real clinical practice, the etiotropic-pathogenetic approach based on information about the effectiveness of individual medical technologies prevails today. It has been established that eight international nonproprietary/grouping names are present in international practice as means of etiotropic therapy for pediatric patients with COVID-19, and 18 positions are used for pathogenetic therapy. In terms of frequency of occurrence, the leading positions are occupied by remdesivir and the combination of nirmatrelvir with ritonavir, as well as dexamethasone and tocilizumab. The paper emphasizes the relevance of research in the field of evaluating the effectiveness of individual treatment regimens as well as the analysis of the delayed consequences of pathology suffered in childhood under the conditions of using various approaches to pharmacotherapy.https://www.mdpi.com/2077-0383/12/14/4731COVID-19pediatricsdrug provisiontreatment |
| spellingShingle | Oksana D. Nemyatykh Marina A. Maistrenko Dina D. Demchenko Igor A. Narkevich Sergey V. Okovityi Vladimir N. Timchenko Principles of Rational COVID-19 Therapy in Pediatrics Journal of Clinical Medicine COVID-19 pediatrics drug provision treatment |
| title | Principles of Rational COVID-19 Therapy in Pediatrics |
| title_full | Principles of Rational COVID-19 Therapy in Pediatrics |
| title_fullStr | Principles of Rational COVID-19 Therapy in Pediatrics |
| title_full_unstemmed | Principles of Rational COVID-19 Therapy in Pediatrics |
| title_short | Principles of Rational COVID-19 Therapy in Pediatrics |
| title_sort | principles of rational covid 19 therapy in pediatrics |
| topic | COVID-19 pediatrics drug provision treatment |
| url | https://www.mdpi.com/2077-0383/12/14/4731 |
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